Characteristics of rhVEGF release from topical hydrogel formulations

Pharmaceutical Research

Volumn 27, Issue 4, 2010, Pages 644-654

  Ji, Junyan A ^a   Liu, Jun ^a   Shire, Steven J ^a   Kamerzell, Tim J ^a   Hong, Sung ^a   Billeci, Karen ^b   Shen, Ye ^a   Wang, Y John ^a  

^a Genentech   (United States)

^b GENENTECH INC   (United States)

Author keywords

Analytical ultracentrifugation; Cd spectroscopy; CMC; Diffusion; HPMC; Hydrogels; Isothermal calorimetry; Methylcellulose; Microviscosity; RhVEGF; Viscosity

Indexed keywords

CARBOXYMETHYLCELLULOSE; GELLING AGENT; HYDROXYPROPYLMETHYLCELLULOSE; RECOMBINANT VASCULOTROPIN; RECOMBINANT PROTEIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ARTICLE; CHEMICAL INTERACTION; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CONFORMATION; DRUG DIFFUSION; DRUG FORMULATION; DRUG RELEASE; HYDROGEL; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; QUANTITATIVE ANALYSIS; SEDIMENTATION; TIME; TOPICAL DRUG ADMINISTRATION; ULTRACENTRIFUGATION; VELOCITY; VISCOSITY; CHEMISTRY; DIFFUSION; DRUG DELIVERY SYSTEM; GEL; HUMAN;

ADMINISTRATION, TOPICAL; CIRCULAR DICHROISM; DIFFUSION; DRUG DELIVERY SYSTEMS; GELS; HUMANS; RECOMBINANT PROTEINS; ULTRACENTRIFUGATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VISCOSITY;

EID: 77953157235     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-0039-4     Document Type: Article

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