MALDI linear TOF mass spectrometry of PEGylated (glyco)proteins

Journal of Mass Spectrometry

Volumn 45, Issue 6, 2010, Pages 612-617

  Seyfried, Birgit K ^a   Siekmann, Jürgen ^b   Belgacem, Omar ^c   Wenzel, Ryan J ^d   Turecek, Peter L ^b   Allmaier, Günter ^a  

^a VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

^b Baxter Innovations   (Austria)

^c Kratos Analytical Ltd   (United Kingdom)

^d Coval X ^*  (Switzerland)

Author keywords

High mass ion detection; MALDI; Mass spectrometry; PEGylation; Recombinant proteins

Indexed keywords

COAGULATION FACTOR; DETECTOR SYSTEMS; GLYCOSYLATED; HIGH MOLECULAR MASS; HIGH MOLECULAR WEIGHT; HUMAN SERUM ALBUMINS; ION DETECTION; LASER DESORPTION/IONIZATION TIME OF FLIGHTS; LIFE-TIMES; MALDI TOF MS; MALDI-MASS SPECTROMETRY; PEGYLATION; PHARMACEUTICAL SCIENCE; PROTEIN PEGYLATION; RECOMBINANT PROTEIN; SECONDARY ELECTRON MULTIPLIERS; SEM; TOF MASS SPECTROMETRY; VON WILLEBRAND FACTOR;

BODY FLUIDS; COAGULATION; DESORPTION; DETECTORS; ELECTRON MULTIPLIERS; IONS; MASS SPECTROMETRY; MOLECULAR WEIGHT;

PROTEINS;

GLYCOSYLATED PROTEIN; HUMAN SERUM ALBUMIN; MACROGOL; PEGINTERFERON ALPHA2A; RECOMBINANT BLOOD CLOTTING FACTOR 8; RECOMBINANT PROTEIN; VON WILLEBRAND FACTOR;

ARTICLE; CHEMICAL MODIFICATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; PEGYLATION; PRIORITY JOURNAL;

FACTOR VIII; GLYCOPROTEINS; HUMANS; INTERFERON ALFA-2A; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; SERUM ALBUMIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VON WILLEBRAND FACTOR;

EID: 77953156970     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1746     Document Type: Article

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