Coactivator P100 protein enhances STAT6-dependent transcriptional activation but has no effect on STAT1-mediated gene transcription

Anatomical Record

Volumn 293, Issue 6, 2010, Pages 1010-1016

  Wang, Xinting ^a,b,c   Liu, Xin ^a,b,c   Fang, Jianfei ^a,b,c   Lu, Yanxin ^a,b,c   He, Jinyan ^a,b,c   Yao, Xuyang ^a,b,c   Yao, Zhi ^a,b,c   Yang, Jie ^a,b,c  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b Tianjin Key Laboratory of Cellular and Molecular Immunology   (China)

^c Education Ministry of China   (China)

Author keywords

CBP p300; IFN ; IL 4; p100; STAT1; STAT6

Indexed keywords

INTERLEUKIN 4; PROTEIN P100; STAT1 PROTEIN; STAT6 PROTEIN;

ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN INTERACTION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; HELA CELLS; HUMANS; INTERLEUKIN-4; MICROSCOPY, CONFOCAL; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 77953154325     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.21143     Document Type: Article

References (28)

1. Caudy AA, Ketting RF, Hammond SM, Denli AM, Bathoorn AMP, Tops BBJ. 2003. A micrococcal nuclease homologue in RNAi effector complexes. Nature 425:411-414.
2. Darnell JE, Jr., Kerr IM, Stark GR. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
3. Gingras S, Moriggl R, Groner B, Simard J. 1999. Induction of3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13. Mol Endocrinol 13:66-81. (Pubitemid 29022280)
4. Horvai AE, Xu L, Korzus E, Brard G, Kalafus D, Mullen TM, Rose DW, Rosenfeld MG, Glass CK. 1997. Nuclear integration of JAK/ STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci USA 94:1074-1079. (Pubitemid 27087806)
5. Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265:1701-1706. (Pubitemid 24314900)
6. Huang Z, Xin J, Coleman J, Huang H. 2005. IFN-csuppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor. J Immunol 174:1332-1337.
7. Ihle JN. 1996. STATs: signal transducers and activators of transcription. Cell 84:331-334.
8. Ingram JL, Rice AB, Geisenhoffer K, Madtes DK, Bonner JC. 2004. IL-13 and IL-1 promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-R. FASEB J 18: 1132-1134. (Pubitemid 39561547)
9. Paukku K, Yang J, Silvennoinen O. 2003. Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5. Mol Endocrinol 17:1805-1814. (Pubitemid 37072296)
10. Kotanides H, Reich NC. 1993. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 262:1265-1267. (Pubitemid 24036092)
11. Kuperman D, Schofield B, Wills-Karp M, Grusby MJ. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med 187:939-948. (Pubitemid 28141667)
12. Leonard W, Oshea J. 1998. Jaks and STATs: biological implications. Annu Rev Immunol 16:293-322.
13. Leverson JD, et al. 1998. Pim-1 kinase and p100 cooperate to enhance c-Myb activity. Mol Cell 2:417-425.
14. Levy DE, Darnell JE, Jr. 2002. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 3:651-662.
15. Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, Weimbs T. 2006. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Dev Cell 10:57-69. (Pubitemid 43025677)
16. Moriggl R, Berchtold S. 1997. Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells. Mol Cell Biol 17:3363-3678.
17. Nam H-W. 2009. IL-4 independent nuclear translocallization of STAT6 in HeLa cells by entry of toxoplasma gondii. Korean J Parasitol 47:117-124.
18. Quarcoo D, Weixler S, Groneberg D, Joachim R, Ahrens B, Wagner AH, Hecker M, Hamelmann E. 2004. Inhibition of signal transducer and activator of transcription 1 attentuates allergen-induced airway inflammation and hyperreactivity. J Allergy Clin Immunol 114:288-295. (Pubitemid 39119026)
19. Quelle FW, Schimoda K, Thierfelder W, Fischer C, Kim A, Nelms K, Paul WE, Ihle JN. 1995. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis Mol Cell Biol 15:3336-3343.
20. Rawlings JS, Rosler KM, Harrison DA. 2004. The JAK/STAT signaling pathway. J Cell Sci 117:1281-1283.
21. Ray R, Choi M, Zhang Z, Silverman GA, Askew D, Mukherjee AB. 2005. Uteroglobin suppresses SCCA gene expression associated with allergic asthma. J Biol Chem 280:9761-9764. (Pubitemid 40395819)
22. Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E. 1995. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. Mol Cell Biol 15:4735-4744.
23. Valineva T, Yang J, Palovuori R, Silvennoinen O. 2005. The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6. J Biol Chem 280:14989-14996. (Pubitemid 40562851)
24. Valineva T, Yang J, Silvennoinen O. 2006. Characterization of RNA helicase A as component of STAT6-dependent enhanceosome. Nucleic Acids Res 34:3938-3946. (Pubitemid 44391009)
25. Walters DM, Antao-Menezes A, Ingram JL, Rice AB, Nyska A, Tani Y, Kleeberger SR, Bonner JC. 2005. Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis. Am J Pathol 167:1221-1229. (Pubitemid 41541409)
26. Wang I-M, Lin H, Goldman SJ, Kobayashi M. 2004. STAT-1 is activated by IL-4 and IL-13 in multiple cell types.Mol Immunol 41:873-884.
27. Yang J, Aittomaki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O. 2002. Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J 21:4950-4958.
28. Yu C-R, Mahdi RM, Ebong S, Vistica BP, Chen J, Guo Y, Gery I, Ewuagu CE. 2004. Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling. J Immunol 173:737-746. (Pubitemid 38924247)