Amino terminal hydrophobic import signals target the p14ARF tumor suppressor to the mitochondria

Cell Cycle

Volumn 9, Issue 4, 2010, Pages 829-839

  Irvine, Mal ^a   Philipsz, Suzanah ^a   Frausto, Monika ^a   Mijatov, Branka ^a   Gallagher, Stuart J ^b   Fung, Carina ^a   Becker, Therese M ^a   Kefford, Richard F ^a   Rizos, Helen ^a  

^a WESTMEAD HOSPITAL   (Australia)

^b Centre de Protontherepie d'Orsay   (France)

Author keywords

Apoptosis; Autophagy; Mitochondria; Nucleolus; P14ARF

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; MITOCHONDRIAL PROTEIN; P32 PROTEIN; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; MITOCHONDRIAL P32 PROTEIN, HUMAN; PROTEIN BCL X;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL DEATH; CONTROLLED STUDY; HYDROPHOBICITY; MITOCHONDRION; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN TRANSPORT; STIMULUS; AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BCL-X PROTEIN; CELL LINE, TUMOR; HUMANS; HYDROPHOBICITY; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77953142296     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.4.10785     Document Type: Article

References (39)

1. Sherr CJ. Divorcing ARF and p53: an unsettled case. Nat Rev Cancer 2006; 6:663-73.
2. Matheu A, Maraver A, Serrano M. The Arf/p53 pathway in cancer and aging. Cancer Res 2008; 68:6031-4.
3. Bertwistle D, Sugimoto M, Sherr CJ. Physical and functional interactions of the ARF tumor suppressor protein with nucleophosmin/B23. Mol Cell Biol 2004; 24:985-96. (Pubitemid 38112164)
4. Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y. Tumor Suppressor ARF Degrades B23, a Nucleolar Protein Involved in Ribosome Biogenesis and Cell Proliferation. Mol Cell 2003; 12:1151-61. (Pubitemid 37487925)
5. Moulin S, Llanos S, Kim SH, Peters G. Binding to nucleophosmin determines the localization of human and chicken ARF but not its impact on p53. Oncogene 2007; 27:2382-9. (Pubitemid 351521094)
6. Sugimoto M, Kuo M-L, Roussel MF, Sherr CJ. Nucleolar ARF tumor suppressor inhibits ribosomal RNA processing. Mol Cell 2003; 11:415-24. (Pubitemid 36293835)
7. ARF in maintaining nucleolar structure and function. Mol Cell Biol 2008; 28:1068-80.
8. ARF tumour suppressor with ribosomes. J Biol Chem 2006; 281:38080-8.
9. Lindstrom MS, Klangby U, Inoue R, Pisa P, Wiman KG, Asker CE. Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus. Exp Cell Res 2000; 256:400-10. (Pubitemid 30244199)
10. ARF. Cancer Res 2005; 65:9834-42.
11. Korgaonkar C, Zhao L, Modestou M, Quelle DE. ARF Function does not require p53 stabilization or Mdm2 relocalization. Mol Cell Biol 2002; 22:196-206. (Pubitemid 33144268)
12. Korgaonkar C, Hagen J, Tompkins V, Frazier AA, Allamargot C, Quelle FW, Quelle DE. Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function. Mol Cell Biol 2005; 25:1258-71.
13. Tao W, Levine AJ. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. Proc Natl Acad Sci USA 1999; 96:3077-80. (Pubitemid 29148846)
14. Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998; 92:725-34. (Pubitemid 28155312)
15. ARF induces autophagy and caspase-independent cell death. Mol Cell 2006; 22:463-75.
16. Itahana K, Zhang Y. Mitochondrial p32 Is a Critical Mediator of ARF-Induced Apoptosis. Cancer Cell 2008; 13:542-53. (Pubitemid 351763900)
17. Weber JD, Kuo ML, Bothner B, DiGiammarino EL, Kriwacki RW, Roussel MF, Sherr CJ. Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Mol Cell Biol 2000; 20:2517-28. (Pubitemid 30152059)
18. Reef S, Shifman O, Oren M, Kimchi A. The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein. Oncogene 2007; 26:6677-83. (Pubitemid 47573682)
19. ARF tumour suppressor mediate nucleolar localization. Oncogene 2000; 19:2978-85.
20. Zhang Y, Xiong Y. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol Cell 1999; 3:579-91.
21. Itahana K, Clegg HV, Zhang Y. ARF in the mitochondria: The last frontier? Cell Cycle 2008; 7:3641-6.
22. Pimkina J, Humbey O, Zilfou JT, Jarnik M, Murphy ME. ARF Induces Autophagy by Virtue of Interaction with Bcl-xl. J Biol Chem 2009; 284:2803-10.
23. Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 2007; 26:2527-39. (Pubitemid 46788315)
24. Rizos H, Darmanian AP, Holland EA, Mann GJ, Kefford RF. Mutations in the INK4a/ARF melanoma susceptibility locus functionally impair p14ARF. J Biol Chem 2001; 276:41424-34. (Pubitemid 37373305)
25. Colombo E, Martinelli P, Zamponi R, Shing DC, Bonetti P, Luzi L, et al. Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant. Cancer Res 2006; 66:3044-50.
26. Claros MG, Vincens P. Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur J Biochem 1996; 241:779-86. (Pubitemid 26379380)
27. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-8.
28. ARF to p53 stabilization. Current Biol 2000; 10:539-42.
29. Kaufmann T, Schinzel A, Borner C. Bcl-w(edding) with mitochondria. Trends Cell Biol 2004; 14:8-12.
30. Rizos H, Puig S, Badenas C, Malvehy J, Darmanian AP, Jiménez L, et al. A melanoma-associated germline mutation in exon 1β inactivates p14ARF. Oncogene 2001; 20:5543-7. (Pubitemid 32889492)
31. Voorhoeve PM, Agami R. The tumor-suppressive functions of the human INK4A locus. Cancer Cell 2003; 4:311-9. (Pubitemid 37329795)
32. Gallagher SG, Kefford RF, Rizos H. The ARF tumour suppressor. Int J Biochem Cell Biol 2006; 38:1637-41.
33. Voorhoeve PM, Agami R. Unraveling Human Tumor Suppressor Pathways: A Tale of the INK4A Locus. Cell Cycle 2004; 3:616-20. (Pubitemid 40278204)
34. den Besten W, Kuo ML, Williams RT, Sherr CJ. Myeloid Leukemia-Associated Nucleophosmin Mutants Perturb p53-Dependent and Independent Activities of the Arf Tumor Suppressor Protein. Cell Cycle 2005; 4:11.
35. INK4a and p16β transcripts in B-lymphoblastoid cells from members of hereditary melanoma families without CDKN2A exon mutations. Oncogene 1997; 15:515-23.
36. Sunayama J, Ando Y, Itoh N, Tomiyama A, Sakurada K, Sugiyama A, et al. Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32. Cell Death Differ 2004; 11:771-81. (Pubitemid 39023123)
37. ARF induces p53-dependent cell cycle arrest but not apoptosis. Cell Cycle 2005; 4:465-72.
38. E4F transcriptional repressor enhances cell cycle inhibition. J Biol Chem 2003; 278:4981-9.
39. Haferkamp S, L TS, Becker TM, Scurr LL, Kefford RF, Rizos H. The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence. Aging 2009; 1:542-56.