ARF in the mitochondria: The last frontier?

Cell Cycle

Volumn 7, Issue 23, 2008, Pages 3641-3646

  Itahana, Koji ^a   Clegg, Hilary V ^a   Zhang, Yanping ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; ARF; Mdm2; Mitochondria; p32; p53

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; COMPLEMENT COMPONENT C1Q; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MITOCHONDRIAL PROTEIN; PROTEIN MDM2; PROTEIN P32; PROTEIN P53; UNCLASSIFIED DRUG;

CELL CYCLE ARREST; CELL CYCLE PROGRESSION; HUMAN; MASS SPECTROMETRY; MITOCHONDRION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW;

EID: 57349113758     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.23.7105     Document Type: Review

References (39)

1. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavitgian SV, Stockert E, Day RS, Johnson BE, Skolnick MH. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994; 264:436-40.
2. Nobori T, Mlura K, Wu DJ, Lois A, Takabayashi K, Carson DA. Deletion of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994; 368:753-6.
3. INK4a/CDK2A tumor suppresor and its relatives. Biochimica et Biophysica Acta 1998; 1378:115-77.
4. Chin L, Pomerantz J, DePinho RA. The INk4a/ARF tumor suppressor: onegene-two products-two pathways. TrendsBiochemSci 1998; 291-6.
5. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408:307-10.
6. Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998; 92:725-34.
7. Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 1998; 92:713-23.
8. ARF, participates in a regulatory feedback loop with p53 and MDM2. EMBO J 1998; 17:5001-14.
9. Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel M, Sherr CJ. Functional and physical interaction of the ARF tumor suppressor with p53 and MDM2. Proc Natl Acad Sci USA 1998; 95:8292-7.
10. Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y. Tumor suppressor ARF degrades B23, a nucleolar protein Involved in ribosome biogenesis and cell proliferation. Mol Cell 2003; 12:1151-64.
11. ARF. Proc Natl Acad Sci USA 1997; 94:3436-40.
12. INK4a and truncation of ARF tumor suppressors in chickens. Proc Natl Acad Sci USA 2003; 100:211-6.
13. Sharpless NE. INK4a/ARF: a multifunctional tumor suppressor locus. Mutat Res 2005; 576:22-38.
14. Greenblatt M. UVM BioDesktop CDKN2a Database. Project (http://biodesktop.uvm.edu/perl/p16). 2006.
15. Greenblatt MS, Beaudet JG, Gump JR, Godin KS, Trombley L, Koh J, Bond JP. Detailed computational study of p53 and p16: using evolutionary sequence analysis and disease-associated mutations to predict the functional consequences of allelic variants. Oncogene 2003; 22:1150-63.
16. Weber JD, Jeffers JR, Rehg JE, Randle DH, Lozano G, Roussel MF, Sherr CJ, Zambetti GP. p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev 2000; 14:2358-65.
17. Reef S, Shifman O, Oren M, Kimchi A. The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein. Oncogene 2007; 26:6677-83.
18. Itahana K, Zhang Y. Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell 2008; 13:542-53.
19. Lindstrom MS, Klangby U, Inoue R, Pisa P, Wiman KG, Asker CE. Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus. Exp Cell Res 2000; 256:400-10.
20. ARF induces autophagy and caspase-independent cell death. Mol Cell 2006; 22:463-75.
21. Ramsby ML, Makowski GS. Differential detergent fractionation of eukaryotic cells. Analysis by two-dimensional gel electrophoresis. Methods Mol Biol 1999; 112:53-66.
22. Hemmati PG, Guner D, Gillissen B, Wendt J, von Haefen C, Chinnadurai G, Dorken B, Daniel PT. Bak functionally complements for loss of Bax during p14(ARF)-induced mitochondrial apoptosis in human cancer cells. Oncogene 2006; 25:6582-94.
23. Ueda Y, Koya T, Yoneda-Kato N, Kato JY. Small mitochondrial ARF (smARF) is located in both the nucleus and cytoplasm, induces cell death, and activates p53 in mouse fibroblasts. FEBS Lett 2008; 582:1459-64.
24. Zhang Y, Xiong Y. Mutation in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol Cell 1999; 3:579-91.
25. Weber JD, Taylor LJ, Roussel MF, Sherr CJ, Bar-Sagi D. Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol 1999; 1:20-6.
26. Weber JD, Kuo M-L, Bothner B, Digiammarino EL, Kriwacki RW, Roussel MF, Sherr CJ. Cooperative signals governing ARF-MDM2 interaction and nucleolar localization of the complex. Mol Cell Biol 2000; 20:2517-28.
27. Korgaonkar C, Zhao L, Modestou M, Quelle DE. ARF function does not require p53 stabilization or Mdm2 relocalization. Mol Cell Biol 2002; 22:196-206.
28. Schatz G, Dobberstein B. Common principles of protein translocation across membranes. Science 1996; 271:1519-26.
29. Neupert W. Protein import into mitochondria. Annu Rev Biochem 1997; 66:863-917.
30. Pfanner N, Geissler A. Versatility of the mitochondrial protein import machinery. Nat Rev Mol Cell Biol 2001; 2:339-49.
31. Claros MG, Vincens P. Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur J Biochem 1996; 241:779-86.
32. Neupert W, Herrmann JM. Translocation of proteins into mitochondria. Annu Rev Biochem 2007; 76:723-49.
33. Ghebrehiwet B, Lim BL, Peerschke EI, Willis AC, Reid KB. Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q. J Exp Med 1994; 179:1809-21.
34. Kunkele KP, Heins S, Dembowski M, Nargang FE, Benz R, Thieffry M, Walz J, Lill R, Nussberger S, Neupert W. The preprotein translocation channel of the outer membrane of mitochondria. Cell 1998; 93:1009-19.
35. Muta T, Kang D, Kitajima S, Fujiwara T, Hamasaki N. p32 protein, a splicing factor 2-associated protein, is localized in mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation. J Biol Chem 1997; 272:24363-70.
36. Dedio J, Jahnen-Dechent W, Bachmann M, Muller-Esterl W. The multiligand-binding protein gC1qR, putative C1q receptor, is a mitochondrial protein. J Immunol 1998; 160:3534-42.
37. Kaufmann T, Schinzel A, Borner C. Bcl-w(edding) with mitochondria. Trends Cell Biol 2004; 14:8-12.
38. Abida WM, Gu W. p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res 2008; 68:352-7.
39. Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004; 305:626-9.