Protective effect of withania somnifera root powder on lipid peroxidation and antioxidant status in gentamicin-induced nephrotoxic rats

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 21, Issue 1, 2010, Pages 61-78

  Jeyanthi, Thangavel ^a   Subramanian, Perumal ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidant; GEN; Lipid peroxidation; Nephrotoxicity; Withania somnifera

Indexed keywords

ANTIOXIDANT; BETA N ACETYLHEXOSAMINIDASE; CATALASE; CREATININE; FREE RADICAL; GENTAMICIN; GLUTATHIONE PEROXIDASE; HYDROPEROXIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UREA; URIC ACID; WITHANIA SOMNIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; AYURVEDA; CONTROLLED STUDY; CREATININE URINE LEVEL; DRUG EFFECT; HISTOPATHOLOGY; KIDNEY TUBULE NECROSIS; LIPID PEROXIDATION; MALE; MICROSCOPY; NEPHROTOXICITY; NONHUMAN; PLANT ROOT; PROTEIN URINE LEVEL; RAT; RENAL PROTECTION; TREATMENT DURATION; UREA BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; URIC ACID URINE LEVEL; WITHANIA SOMNIFERA;

ANIMALS; ANTIOXIDANTS; CATALASE; GENTAMICINS; KIDNEY; KIDNEY DISEASES; LIPID PEROXIDATION; LIVER; MALE; PLANT EXTRACTS; PLANT ROOTS; POWDERS; PROTECTIVE AGENTS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES; UREA; WITHANIA;

EID: 77953141187     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/JBCPP.2010.21.1.61     Document Type: Article

References (60)

1. Ali, BH. Agents ameliorating or augmenting experimental GEN nephrotoxicity. some recent research. Food Chem Toxicol 2003;41: 1447-52.
2. Edson, RS, Terrell, CL. The aminoglycosides. Mayo Clinic Proceedings 1999;74:519-28.
3. Smetana, S, Khalef, S, Nitsan, Z, Hurwitz, N. Miskin, A, Bar-Khayim, Y, et al. Enhanced urinary trypsin inhibitory activity in GEN-induced nephrotoxicity in rats. Clin Chim Acta 1988:76:333-42.
4. Cuzzocrea, S, Mazzon, E, Dugo, L, Serraino, I, Di Paola, R, Britti, D. A role for superoxide in GEN-mediated nephropathy in rats. Eur J Pharmacol 2002;16:67–76.
5. Yang, CL, Du, XH, Han, YX. Renal cortical mitochondria are source of oxygen free radicals enhanced by GEN. Renal Failure 1995;17:21-6.
6. Parlakpinar, H, Tasdemir, S, Polat, A, Bay-Karabulut, A, Vardi, N, Ucar, M, et al. Protective role of caffeic acid phenethyl ester (cape) on GEN-induced acute renal toxicity in rats. Toxicology 2005;207:169-77.
7. Longoni, B, Migliori, M, Ferretti, A, Origlia, N, Panichi, V, Boggi, U, et al. Melatonin prevents cyclosporine-induced nephrotoxicity in isolated and perfused rat kidney. Free Radic Res 2002;36:357-63.
8. Piotrowski, WJ, Pietras, T, Kurmanowska, Z, Nowak, D, Marczak, J, Marks-Konczalik, J, et al. Effect of paraquatintoxication and ambroxol treatment on hydrogen peroxide production and lipid peroxidation in selected organs of rat. J. Appl Toxicol 1996;16:501-7.
9. Yanagida, C, Ito, K, Komiya, I, Horie, T. Protective effect of fosfomycin on GEN-induced lipid peroxidation of rat renal tissue. Chem Biol Interact 2004;148:139-47.
10. Tripathy, AK, Shukla, YN, Kumar, S. Ashwagandha, W. somnifera. Dunal_Solanaceae. A status report. Med Arom plant Sci 1996;18:46–62.
11. Gupta, GL, Rana, AC. W. somnifera (Ashwagandha); A Review Pharmacognosy Rev 2007;1: Issue 1.
12. Ziauddin, M, Phansalkar, N, Patki, P, Diwanay, S, Patwardhan, B. Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol 1996;50:9–76.
13. Bhattacharya, SK, Satyan, KS, Chakrabarti, A. Effect of Trasina, an Ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity in hyperglycemic rats. Indian J Exp Biol 1997,35:297-9.
14. Rai, D, Bhatia, G, Sen, T, Palit, G. Anti-stress effects of Ginkgo biloba and Panax ginseng a comparative study. J Pharmacol Sci 2003;93:458-64.
15. Mohan, R, Hammers, HJ, Bargagna-Mohan, P, Zhan, XH, Herbstritt, CJ, Ruiz, A, et al. Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis 2004;7:115-22.
16. Yokota, Y, Bargagna-Mohan, P, Ravindranath, PP, Kim, KB, Mohan, R. Development of withaferin A analogs as probes of angiogenesis. Bioorg Med Chem Lett 2006;16:2603-7.
17. Bhattacharya, SK, Muruganandam, AV. Adaptogenic activity of W somnifera an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav 2003;75:547-55.
18. Jayaprakasam, B, Zhang, Y, Seeram, NP, Nair, MG. Growth inhibition of human tumor cell lines by withanolides from W. somnifera leaves. Life Sci 2003;74:125-32.
19. Ahmad, M, Saleem, S, Ahmad, AS, Ansari, MA, Yousuf, S, Hoda, MN, Islam, F. Neuroprotective effects of Withania somnifera on 6-hydroxy-dopamineinduced Parkinsonism in rats. Hum Exp Toxicol 2005;24: 137-47.
20. Mishra, LC, Singh, BB, Dagenais, S. Scientific basis for the therapeutic use of W. somnifera (ashwagandha):a review. Ah Med Rev 2000; 5:334–346.
21. Mohanty, I, Arya, DS, Dinda, A, Talwar, KK, Joshi, S, Gupta, SK. Mechanisms of cardioprotective effect of Withania somnifera in experimentally induced myocardial infarction. Basic Clin Pharmacol Toxicol 2004;94:184-90.
22. Falsey, RR, Marron, MT, Gunaherath, GM, Shirahatti, N, Mahadevan, D, Gunatilaka, AA, et al. Actin microfilament aggregation induced by withaferin A is mediated by annexin II. Nat Chem Biol 2006;2:33-8.
23. Sankar, SR, Manivasagam, T, Krishnamurti, A, Ramanathan, M. The neuroprotective effect of Withania somnifera root extract in MPTP-intoxicated mice: an analysis of behavioral and biochemical variables. Cell Mol Biol Lett 2007;12:473-81.
24. Umadevi, P. Withania somnifera dunal (Ashwagandha): potential plant source of promising drug for cancer chemotherapy and radiosensitization. Indian J Exp Biol 1996;34:927-32.
25. Ganzera, M, Choudhary, MI, Khan, lA. Quantitative HPLC analysis of withanoiides in Withania somnifera. Fitoterapia 2003;74:68–76.
26. Jayaprakasam, B, Nair, MG. Cyclooxygenase-2 enzyme inhibitory withanoiides from Withania somnifera leaves Tetrahedron 2003;59:841-9.
27. Ozbek, E, Turkoz, Y, Shna, E, Ozugulu, F, Mizrak, B, Ozbek, M. Melatonin administration prevents the nephrotoxicity induced by GEN. Br J Urology 2000;85:742-6.
28. Matsuda, H, Murakami, T, Kishi, A, Yoshikawa, M. Structures of w ithanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum. Bioorg Med Chem 2001;9:1499-507.
29. Pedraza-Chaverri, J, Gonzalez-Orozco, AE, Maldonado, PD, Barrera, D, Medina-Campos, ON, Hemandez-Pando, R. Diallyl disulfide ameliorates GEN-induced oxidative stress and nephropathy in rats. Eur J Pharmacol 2003;473:71–78.
30. Maldonado, PD, Barrera, D, Medina-Campos, ON, Herna'ndez-Pandor, Ibarra-Rubio, ME, Pedraza-Chaverri, J. Aged garlic extract attenuates GEN induced renal damage and oxidative stress. Life Sci 2003;73:2543-56.
31. Devipriya, S, Shymaladevi, CS. Protective effect of quercetin in cisplatin induced cell injury in the rat kidney. J Pharmaco 1999;431:422.
32. Prakash, J, Gupta, SK, Dinda, AK. Withania somnifera root extract prevents DMBA-induced squamous cell carcinoma of skin in Swiss albino mice. Nutr Cancer 2002;42:91-7.
33. Padmavathi, B, Rath, PC, Rao, AR, Singh, RP. Roots of Withania somnifera inhibit fore stomach and skin carcinogenesis in mice. eCAM 2005;2:99–105.
34. Russo, A, Lzzo, AA, Cardile, V, Borrelli, G, Vanella, A. Indian medicinal plants as antiradicals and DNA cleavage protectors. Phytomedicine 2001;8:125-32.
35. Jayaprakasam,B, Nair, MG. Cyclooxygenase-2 enzyme inhibitory withanoiides from Withania somnifera leaves. Tetrahedron 2002;59:841-9.
36. Rasool, M, Varalakshmi, P. Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study. Vasc Pharmacol 2006;44:406-10.
37. Natelson, S. Microtechniques of clinical chemistry for the Routine Laboratory C, C. Thomas spring field, Illinois, 1957;381.
38. Bonsnes, RW, Taussky, HH. On the colorimetric determination of creatinine by the Jaffee Reaction. JBiol Chem 1945;158:581.
39. Brown, H. The determination of uric acid in human blood. J Biol Chem 1945;158:601.
40. Wolfson, WQ, Cohn, C, Calvary, E, Ichiba, F. Studies in serum proteins rapid procedure for estimation of total proteins, true albumin, total globulin, alpha globulin, beta globulin, gamma globulin in 1.0 ml of serum. Amer J Clin Path 1948;18:723-30.
41. Rice, EW. Improved biuret procedure for routine determination of urinary total proteins in clinical proteinuria. Clin Chem 1975;21:398–401.
42. Price, RG, Dance, N, Richards, B, Catell, WR. The excretion of N-acetyl-B-glucosaminidase, and B-galactosidase following surgery to the kidney. Clin Chim Acta 1970,27:65–70.
43. Yagi, K. Lipid peroxides and human disease. Chem Phys Lipids 1987; 45:337-51.
44. Fraga, CG, Leibovitz, BF, Toppei, AL. Lipid peroxidation measured as TBARS in tissue slices. Characterization and comparison with homo-genate and microsomes. Free Radie Biol Med 1988;4:155-61.
45. Jiang, ZY, Hunt, JV, Wolff, SP. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxides in low-density lipoprotein. Anal Biochem 1992;202:384-9.
46. Sinha, KA. Colorimetric assay of catalase. Anal Biochem 1972;47:389-94.
47. Ellman, GC. Tissue sulfhydyl groups. Arch Biochem Biophys 1959; 82:70-7.
48. Rotruck, JT, Pope, AL, Ganther, HE, Swason, AB. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973;179:588-90.
49. Kakkar, P, Das, B, Viswanathan, PN. A modified spectrophotometric assay of SOD. Ind J Biochem Biophys 1984;21:130-2
50. Erdem, A, Gundogan, NU, Usubutun, A, Kilinc, K, Erdem, SR, Kara, A, et al. The protective effect of taurine against GEN induced acute tubular necrosis in rats. Nephrol Dial Transplant 2000;15:1175-82.
51. Harlalka, GV, Patil, CR, Patil, MR. Protective effect of kalanchoe pinnata (Crassulaceae) on GEN-induced nephrotoxicity in rats. Indian J Pharamacol 2007;39:201-5.
52. Kopple,JD, Ding, H, Letoha, A, Ivanyi, B, Qing, DP, Dux, L, et al. I-Camitine ameliorates GEN-induced renal injury in rats. Nephrol Dial Transplant 2002; 17:2122-31.
53. Atessahin, A, Yilmaz, S, Karahan, I, Ceribasi, AO, Karaoglu, A. Effects of lycopcne against cisplatin-induce nephrotoxicity and oxidative stress in rats. Toxicology 2005;212:116-23.
54. Chaurasia, SS, Panda, S, Kar, A. Withania somnifera root extract in the regulation of lead-induced oxidative damage in male mouse. Pharmacol Res 2000;41:663-6.
55. Davis, L, Kuttan, G. Effect of Withania somnifera on cytokine production in normal and cyclophosphamide treated mice. Immunopharmacol Immunotoxicol 1999;21:695–703.
56. Jagetia, GC, Rajanikant, GK, Rao, SK, Baliga, MS. Alteration in glutathione, glutathione peroxidase, superoxide dismutase, and lipid peroxidation by ascorbic acid in the skin of mice exposed to fractionated gamma radiation. Clin Chim Acta 2003;332:111-21
57. Walker, PD, Shah, SV. Evidence suggesting a role for hydroxyl radical in gentamicin induced acute renal failure in rats. J Clin Invest 1988; 81:334–341.
58. Dhuley, JN. Adaptogenic and cardio protective action of Ashwagandha in rats and frogs. J Ethanopharmacol 2000;70:57–63.
59. Parihar, MS, Hemnani, T. Phenolic antioxidants attenuate hippocampal neuronal cell damage against kainic acid induced excitotoxicity. J Biosci 2003;28:121-8.
60. Schaefer, W, Hoffman, T, Schultz, G, Gudermann, T. A new prostaglandin E receptor mediates calcium influx and acrosome reaction in human spermatozoa. Proc Natl Acad Sci USA 1998;95:3008-13.