ppGpp analogues inhibit synthetase activity of Rel proteins from Gram-negative and Gram-positive bacteria

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4485-4497

  Wexselblatt, Ezequiel ^a   Katzhendler, Jehoshua ^a   Saleem Batcha, Raspudin ^b   Hansen, Guido ^b   Hilgenfeld, Rolf ^b   Glaser, Gad ^a   Vidavski, Roee R ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Antibacterial; ppGpp; RelA; Stringent response

Indexed keywords

2' DEOXYGUANOSINE 3' 5' DI(METHYLENE BISPHOSPHONATE); DEOXYGUANOSINE DERIVATIVE; GUANOSINE TRIPHOSPHATE; HYDROLASE; RNA; SYNTHETASE; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; GUANOSINE 3' DIPHOSPHATE 5' DIPHOSPHATE; GUANOSINE 3',5'-POLYPHOSPHATE SYNTHETASES; LIGASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BIOLOGICAL ACTIVITY; COMPUTER MODEL; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG ACTIVITY; DRUG BINDING; DRUG SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; MODULATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN PURIFICATION; RIBOSOME; RNA REPLICATION; RNA SYNTHESIS; RNA TRANSLATION; VIRUS INDUCTION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; ENZYMOLOGY; METABOLISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; GUANOSINE TETRAPHOSPHATE; LIGASES; MOLECULAR CONFORMATION;

MAMMALIA; NEGIBACTERIA; POSIBACTERIA;

EID: 77953134680     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.064     Document Type: Article

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