Design and synthesis of novel neuroprotective 1,2-dithiolane/chroman hybrids

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 17, 2009, Pages 6432-6441

  Koufaki, Maria ^a   Kiziridi, Christina ^a   Alexi, Xanthippi ^a   Alexis, Michael N ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

Author keywords

1,2 Dithiolane; Bioisosterism; Chroman; Neuronal damage; Oxidative stress

Indexed keywords

1,2 DITHIOLANE DERIVATIVE; 1,2,3 TRIAZOLE DERIVATIVE; 1,2,4 OXADIAZOLE DERIVATIVE; 1,3,4 OXADIAZOLE DERIVATIVE; 3 [6 (1,2 DITHIOLAN 3 YL)PENTYL] 5 [2 (3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2H BENZOPYRAN)] 1,2,4 OXADIAZOLE; AMIDE; CHROMAN DERIVATIVE; GLUTAMIC ACID; HETEROCYCLIC COMPOUND; NEUROPROTECTIVE AGENT; NITROGEN; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HIPPOCAMPUS; HYBRID; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHROMANS; DRUG DESIGN; HIPPOCAMPUS; MICE; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; THIOCTIC ACID;

EID: 68649117411     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.010     Document Type: Article

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