Synthesis and biological activity of N-aroyl-tetrahydro-γ-carbolines

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 3910-3924

  Bridoux, Alexandre ^a   Millet, Régis ^a   Pommery, Jean ^a   Pommery, Nicole ^a   Henichart, Jean Pierre ^a  

^a Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

Author keywords

2D NMR; 5 LOX COXs dual inhibitors; Cytotoxicity; Tetrahydro carbolines

Indexed keywords

2 {3 [3 FLUORO 5 (4 METHOXYTETRAHYDRO 4H 4 PYRANYL)PHENOXY]PROPYL} 5 (4 METHANESULFONYLBENZYL) 8 METHOXY 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 2 {3 [3 FLUORO 5 (4 METHOXYTETRAHYDRO 4H 4 PYRANYL)PHENOXY]PROPYL} 8 METHOXY 5 (2,4,6 TRICHLOROBENZOYL) 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 5 (2 FLUOROBENZOYL) 2 {3 [3 FLUORO 5 (4 METHOXYTETRAHYDRO 4H 4 PYRANYL)PHENOXY]PROPYL} 8 METHOXY 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 5 (3 FLUOROBENZOYL) 2 {3 [3 FLUORO 5 (4 METHOXYTETRAHYDRO 4H 4 PYRANYL)PHENOXY]PROPYL} 8 METHOXY 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 5 (4 BROMOBENZOYL) 2 {3 [3 FLUORO 5 (4 METHOXYTETRAHYDRO 4H 4 PYRANYL)PHENOXY]PROPYL} 8 METHOXY 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 5 (4 CHLOROBENZOYL) 2 {3 [3 FLUORO 5 (4 METHOXYTETRAHYDRO 4H 4 PYRANYL)PHENOXY]PROPYL} 8 METHOXY 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 5 (4 DIMETHYLAMINOMETHYLENAMINOSULFONYLBENZOYL) 2 {3 [3 FLUORO 5 (4 METHOXYTETRAHYDRO 4H 4 PYRANYL)PHENOXY]PROPYL} 8 METHOXY 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 5 (4 FLUOROBENZOYL) 2 {3 [3 FLUORO 5 (4 METHOXYTETRAHYDRO 4H 4 PYRANYL)PHENOXY]PROPYL} 8 METHOXY 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 5 BENZOYL 2 {3 [3 FLUORO 5 (4 METHOXYTETRAHYDRO 4H 4 PYRANYL)PHENOXY]PROPYL} 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 5 BENZOYL 2 {3 [3 FLUORO 5 (4 METHOXYTETRAHYDRO 4H 4 PYRANYL)PHENOXY]PROPYL} 8 METHOXY 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 5 BENZOYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 5 BENZOYL 8 METHOXY 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE; 6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 1 METHYL 2 QUINOLONE; ACETYLSALICYLIC ACID; ATRASENTAN; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DICLOFENAC; DOCETAXEL; INDOMETACIN; ITAZIGREL; KETOROLAC; LEUKOTRIENE RECEPTOR BLOCKING AGENT; N AROYL TETRAHYDRO GAMMA CARBOLINE; PREDNISONE; PROSTAGLANDIN SYNTHASE INHIBITOR; TEPOXALIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZILEUTON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; PROSTATE CANCER;

EID: 77953128895     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.034     Document Type: Article

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