A novel one-pot palladium-mediated synthesis of N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl) acetamide, the precursor to [11C]PBR28, a PET biomarker for the peripheral benzodiazepine receptor

Tetrahedron Letters

Volumn 51, Issue 26, 2010, Pages 3353-3355

  Hoareau, Raphaël ^a   Scott, Peter J H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

11C PBR28; Positron emission tomography; Radiopharmaceutical synthesis

Indexed keywords

AMINOPYRIDINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; N [(2 HYDROXYPHENYL)METHYL] N (4 PHENOXY 3 PYRIDINYL)ACETAMIDE; PALLADIUM; PBR 28; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; DRUG SYNTHESIS; ONE POT SYNTHESIS; POSITRON EMISSION TOMOGRAPHY; REDUCTION;

EID: 77953123513     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.04.089     Document Type: Article

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29. +), 293.1290; found, 293.1287.
30. 3, 500 MHz): δ 2.17-4.69 (m, 10H), -0.11 to 1.46 (m, 4H).
31. +), 357.1215; found, 357.1200.