Obligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg2+-coordinating Thr of regulatory GTPases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 21, 2010, Pages 9596-9601

  Zurita, Adolfo ^a   Zhang, Yinghao ^a   Pedersen, Lee ^a   Darden, Tom ^a   Birnbaumer, Lutz ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Catalytic water; Ensymes hydrolases; Heterotrimeric G proteins; Protein metal ion interaction

Indexed keywords

ALANINE; ASPARTIC ACID; CARBONYL OXYGEN; GLUTAMIC ACID; GLUTAMINE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MAGNESIUM; OXYGEN; PROTEIN SWITCH I; RAS PROTEIN; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVATION; HYDROLYSIS; PRIORITY JOURNAL;

ANIMALS; CATIONS, DIVALENT; CELL LINE; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEIN ALPHA SUBUNITS; GUANOSINE TRIPHOSPHATE; HYDROLYSIS; MAGNESIUM; MICE; MUTATION; OXYGEN; PROTEIN BINDING; THREONINE;

EID: 77953095628     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004803107     Document Type: Article

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