Listeria-derived ActA is an effective adjuvant for primary and metastatic tumor immunotherapy

Cancer Immunology, Immunotherapy

Volumn 59, Issue 7, 2010, Pages 1049-1058

  Wood, Laurence M ^a   Pan, Zhen Kun ^a   Shahabi, Vafa ^b   Paterson, Yvonne ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ADVAXIS INC   (United States)

Author keywords

ActA; Adjuvant; Cancer; Immunotherapy; Listeria monocytogenes; Vaccine

Indexed keywords

GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; PROTEIN ACTA; PROTEIN E7; UNCLASSIFIED DRUG; ACTA PROTEIN, LISTERIA MONOCYTOGENES; BACTERIAL PROTEIN; CANCER VACCINE; MEMBRANE PROTEIN; ONCOGENE PROTEIN E7, HUMAN PAPILLOMAVIRUS TYPE 16; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; BACTERIAL VIRULENCE; CANCER CONTROL; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; IMMUNOLOGICAL TOLERANCE; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLID TUMOR; T CELL DEPLETION; TUMOR IMMUNITY; ANIMAL; C57BL MOUSE; EXPERIMENTAL NEOPLASM; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; MALE; METASTASIS; METHODOLOGY; PATHOLOGY; TRANSGENIC MOUSE; TREATMENT OUTCOME; TUMOR CELL LINE; TUMOR VOLUME;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, NEOPLASM; BACTERIAL PROTEINS; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; FEMALE; HUMANS; IMMUNOTHERAPY; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; PAPILLOMAVIRUS E7 PROTEINS; TREATMENT OUTCOME; TUMOR BURDEN;

EID: 77953067149     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-010-0830-4     Document Type: Article

References (36)

1. Coley WB (1991) The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893. Clin Orthop Relat Res 262:3-11
2. B Wiemann CO Starnes 1994 Coley's toxins, tumor necrosis factor and cancer research: a historical perspective Pharmacol Ther 64 3 529 564 10.1016/0163-7258(94)90023-X 1:CAS:528:DyaK2MXjtVOrt70%3D 7724661 (Pubitemid 24381235)
3. A Morales D Eidinger AW Bruce 1976 Intracavitary Bacillus Calmette-Guerin in the treatment of superficial bladder tumors J Urol 116 2 180 183 1:STN:280:DyaE283ktVOrtA%3D%3D 820877
4. TL Ratliff 1991 Bacillus Calmette-Guerin (BCG): mechanism of action in superficial bladder cancer Urology 37 Suppl 5 8 11 10.1016/0090-4295(91)80127-S 1:STN:280:DyaK3M3htlekug%3D%3D 2021034
5. Guirnalda P, Wood L, Seavey MM, Paterson Y (2009) Bacterial based anti-tumor immunotherapeutic strategies. In: Morrow J, Schmidt C, Davies H, Sheikh N (eds) Vaccinology: principles and practice, Chapter 19. Wiley-Blackwell, NJ
6. S Yuan C Shi W Han R Ling N Li T Wang 2009 Effective anti-tumor responses induced by recombinant Bacillus Calmette-Guerin vaccines based on different tandem repeats of MUC1 and GM-CSF Eur J Cancer Prev 18 5 416 423 10.1097/CEJ.0b013e32832c3882 1:CAS:528:DC%2BD1MXhtV2itLnK 19550341
7. A Wallecha KD Carroll PC Maciag S Rivera V Shahabi Y Paterson 2009 Multiple effector mechanisms induced by recombinant Listeria monocytogenes anticancer immunotherapeutics Adv Appl Microbiol 66 1 27 10.1016/S0065-2164(08) 00801-0 1:CAS:528:DC%2BD1MXks1ynsrc%3D 19203646
8. R Singh Y Paterson 2006 Listeria monocytogenes as a vector for tumor-associated antigens for cancer immunotherapy Expert Rev Vaccines 5 4 541 552 10.1586/14760584.5.4.541 1:CAS:528:DC%2BD28XpvVCktL0%3D 16989634 (Pubitemid 44627884)
9. DA Sewell V Shahabi GR Gunn Z-K Pan ME Dominiecki Y Paterson 2004 Recombinant Listeria vaccines containing PEST sequences are potent immune adjuvants for the tumor-associated antigen HPV-16 E7 Cancer Res 64 24 8821 8825 10.1158/0008-5472.CAN-04-1958 1:CAS:528:DC%2BD2cXhtVOmsL7M 15604239 (Pubitemid 39665484)
10. X Peng J Treml Y Paterson 2007 Adjuvant properties of listeriolysin O protein in a DNA vaccination strategy Cancer Immunol Immunother 56 6 797 806 10.1007/s00262-006-0240-9 1:CAS:528:DC%2BD2sXjsFyhtbo%3D 17102978 (Pubitemid 46723587)
11. AA Tobian CV Harding DH Canaday 2005 Mycobacterium tuberculosis heat shock fusion protein enhances class I MHC cross-processing and presentation by B lymphocytes J Immunol 174 9 5209 5214 1:CAS:528:DC%2BD2MXjsVertro%3D 15843516
12. P Schnupf J Zhou A Varshavsky DA Portnoy 2007 Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway Infect Immun 75 11 5135 5147 10.1128/IAI.00164-07 1:CAS:528: DC%2BD2sXht1CrtLzL 17682039 (Pubitemid 350033600)
13. GR Gunn A Zubair CH Peters Z-K Pan T-C Wu Y Paterson 2001 Two L. monocytogenes vaccine vectors that express different molecular forms of HPV-16 E7 induce qualitatively different T-cell immunity that correlates with their ability to induce regression of established tumors immortalized by HPV-16 J Immunol 167 11 6471 6479 1:CAS:528:DC%2BD3MXovVCit7c%3D 11714814
14. C Kohda I Kawamura H Baba T Nomura Y Ito T Kimoto, et al. 2002 Dissociated linkage of cytokine-inducing activity and cytotoxicity to different domains of listeriolysin O from Listeria monocytogenes Infect Immun 70 3 1334 1341 10.1128/IAI.70.3.1334-1341.2002 1:CAS:528:DC%2BD38XhsFSlsLo%3D 11854218 (Pubitemid 34163409)
15. MA Hamon E Batsche B Regnault TN Tham S Seveau C Muchardt, et al. 2007 Histone modifications induced by a family of bacterial toxins Proc Natl Acad Sci USA 104 33 13467 13472 10.1073/pnas.0702729104 1:CAS:528:DC%2BD2sXps1Kgur4%3D 17675409 (Pubitemid 47293968)
16. AM Krieg 2007 Development of TLR9 agonists for cancer therapy J Clin Invest 117 5 1184 1194 10.1172/JCI31414 1:CAS:528:DC%2BD2sXlt1OmtrY%3D 17476348 (Pubitemid 46718403)
17. DA Sewell D Douven ZK Pan A Rodriguez Y Paterson 2004 Regression of HPV-positive tumors treated with a new Listeria monocytogenes vaccine Arch Otolaryngol Head Neck Surg 130 1 92 97 10.1001/archotol.130.1.92 14732776 (Pubitemid 38095437)
18. NC Souders DA Sewell ZK Pan SF Hussain A Rodriguez A Wallecha, et al. 2007 Listeria-based vaccines can overcome tolerance by expanding low avidity CD8 + T cells capable of eradicating a solid tumor in a transgenic mouse model of cancer Cancer Immun 7 2 17279610
19. E Domann J Wehland M Rohde S Pistor M Hartl W Goebel, et al. 1992 A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin EMBO J 11 5 1981 1990 1:CAS:528:DyaK3sXitVKgu7k%3D 1582425
20. C Kocks E Gouin M Tabouret P Berche H Ohayon P Cossart 1992 L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein Cell 68 3 521 531 10.1016/0092-8674(92)90188-I 1:CAS:528: DyaK38XhsVOrtr8%3D 1739966
21. MD Welch A Iwamatsu TJ Mitchison 1997 Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes Nature 385 6613 265 269 10.1038/385265a0 1:CAS:528:DyaK2sXlslCgtA%3D%3D 9000076 (Pubitemid 27043727)
22. Y Yoshikawa M Ogawa T Hain M Yoshida M Fukumatsu M Kim, et al. 2009 Listeria monocytogenes ActA-mediated escape from autophagic recognition Nat Cell Biol 11 10 1233 1240 10.1038/ncb1967 1:CAS:528:DC%2BD1MXht1SqsLnL 19749745
23. MA Moors V Auerbuch DA Portnoy 1999 Stability of the Listeria monocytogenes ActA protein in mammalian cells is regulated by the N-end rule pathway Cell Microbiol 1 3 249 257 10.1046/j.1462-5822.1999.00020.x 1:CAS:528:DC%2BD3cXisVyrt7s%3D 11207557
24. C Ledent A Marcotte JE Dumont G Vassart M Parmentier 1995 Differentiated carcinomas develop as a consequence of the thyroid-specific expression of a thyroglobulin-human papillomavirus type 16 E7 transgene Oncogene 10 9 1789 1797 1:CAS:528:DyaK2MXls1artLc%3D 7753555
25. H Ji EY Chang KY Lin RJ Kurman DM Pardoll TC Wu 1998 Antigen-specific immunotherapy for murine lung metastatic tumors expressing human papillomavirus type 16 E7 oncoprotein Int J Cancer 78 1 41 45 10.1002/(SICI)1097-0215(19980925) 78:1<41::AID-IJC8>3.0.CO;2-X 1:CAS:528:DyaK1cXlvVarsL0%3D 9724092 (Pubitemid 28391672)
26. MC Feltkamp HL Smits MP Vierboom RP Minnaar BM de Jongh JW Drijfhout, et al. 1993 Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells Eur J Immunol 23 9 2242 2249 10.1002/eji.1830230929 1:CAS:528: DyaK2cXivVynsw%3D%3D 7690326
27. Schrieber H (2003) Tumor Immunology. In: Paul WE (ed) Fundamental Immunology. Lippincott Williams and Wilkins, Philadelphia, pp 1557-1592
28. AN Houghton 1994 Cancer antigens: immune recognition of self and altered self J Exp Med 180 1 1 4 10.1084/jem.180.1.1 1:CAS:528:DyaK2cXktlalsb8%3D 8006576 (Pubitemid 24181047)
29. M Bruley-Rosset I Florentin G Mathe 1976 In vivo and in vitro macrophage activation by systemic adjuvants Agents Actions 6 1-3 251 255 10.1007/BF01972217 1:STN:280:DyaE283kvFyqug%3D%3D 782207
30. G Hartmann AM Krieg 1999 CpG DNA and LPS induce distinct patterns of activation in human monocytes Gene Ther 6 5 893 903 10.1038/sj.gt.3300880 1:CAS:528:DyaK1MXjtVKgtL0%3D 10505115 (Pubitemid 29243664)
31. DM Klinman AK Yi SL Beaucage J Conover AM Krieg 1996 CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma Proc Natl Acad Sci USA 93 7 2879 2883 10.1073/pnas.93.7.2879 1:CAS:528:DyaK28XitVCit7w%3D 8610135 (Pubitemid 26116242)
32. A D'Andrea M Rengaraju NM Valiante J Chehimi M Kubin M Aste, et al. 1992 Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells J Exp Med 176 5 1387 1398 10.1084/jem.176.5.1387 1357073
33. SF Wolf D Sieburth J Sypek 1994 Interleukin 12: a key modulator of immune function Stem Cells 12 2 154 168 10.1002/stem.5530120203 1:CAS:528: DyaK2cXktVKksrg%3D 7911046
34. S Pistor T Chakraborty U Walter J Wehland 1995 The bacterial actin-nucleator protein ActA of Listeria monocytogenes contains multiple binding sites for host microfilament proteins Curr Biol 5 5 517 525 10.1016/S0960-9822(95)00104-7 1:CAS:528:DyaK2MXlsFSmtLk%3D 7583101
35. JA Swanson 2008 Shaping cups into phagosomes and macropinosomes Nat Rev Mol Cell Biol 9 8 639 649 10.1038/nrm2447 1:CAS:528:DC%2BD1cXosl2rsLY%3D 18612320
36. JK Burkhardt E Carrizosa MH Shaffer 2008 The actin cytoskeleton in T-cell activation Annu Rev Immunol 26 233 259 10.1146/annurev.immunol.26.021607.090347 1:CAS:528:DC%2BD1cXltlWksbo%3D 18304005 (Pubitemid 351600376)