Difluoromethylornithine inhibits hypertrophic, pro-fibrotic and pro-apoptotic actions of aldosterone in cardiac cells

Amino Acids

Volumn 38, Issue 2, 2010, Pages 525-531

  Cetrullo, S ^a   Facchini, A ^a   Stanic, I ^a,b   Tantini, B ^a   Pignatti, C ^a   Caldarera, C M ^b   Flamigni, F ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b National Institute for Cardiovascular Research   (Italy)

Author keywords

Aldosterone; Apoptosis; Cardiac cells; Difluoromethylornithine; Hypertrophy; Polyamines

Indexed keywords

ALDOSTERONE; ATRIAL NATRIURETIC FACTOR; CASPASE; EFLORNITHINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MYOSIN HEAVY CHAIN BETA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SURVIVIN; TRANSCRIPTION FACTOR GATA 4; POLYAMINE;

ANIMAL CELL; APOPTOSIS; CELL SURVIVAL; CELL TYPE; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HEART MUSCLE CELL; HORMONE ACTION; HORMONE INHIBITION; NEWBORN; NONHUMAN; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; RAT; UPREGULATION; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CYTOLOGY; FIBROSIS; GENE EXPRESSION; HEART DISEASE; HYPERTROPHY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; WISTAR RAT;

RATTUS;

ALDOSTERONE; ANIMALS; APOPTOSIS; BIOGENIC POLYAMINES; CELLS, CULTURED; EFLORNITHINE; FIBROSIS; GENE EXPRESSION; HEART DISEASES; HYPERTROPHY; MYOCYTES, CARDIAC; RATS; RATS, WISTAR;

EID: 77953059309     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-009-0413-x     Document Type: Conference Paper

References (31)

1. Abbate A, Scarpa S, Santini D, Palleiro J, Vasaturo F, Miller J, Morales C, Vetrovec GW, Baldi A (2006) Myocardial expression of survivin, an apoptosis inhibitor, in aging and heart failure. An experimental study in the spontaneously hypertensive rat. Int J Cardiol 111:371-376
2. Bachrach U, Wang YC, Tabib A (2001) Polyamines: new cues in cellular signal transduction. News Physiol Sci 16:106-109
3. Chai W, Danser AH (2006) Why are mineralocorticoid receptor antagonists cardioprotective? Naunyn Schmiedebergs Arch Pharmacol 374:153-162
4. Chun TY, Pratt JH (2005) Aldosterone increases plasminogen activator inhibitor-1 synthesis in rat cardiomyocytes. Mol Cell Endocrinol 239:55-61
5. Flamigni F, Rossoni C, Stefanelli C, Caldarera CM (1986) Polyamine metabolism and function in the heart. J Mol Cell Cardiol 18:3-11
6. Flamigni F, Stanic I, Facchini A, Cetrullo S, Tantini B, Borzi RM, Guarnieri C, Caldarera CM (2007) Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells. Amino Acids 33:197-202
7. Gerner EW, Meyskens FL Jr (2004) Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer 4:781-792
8. Han L, Xu C, Jiang C, Li H, Zhang W, Zhao Y, Zhang L, Zhang Y, Zhao W, Yang B (2007) Effects of polyamines on apoptosis induced by simulated ischemia/reperfusion injury in cultured neonatal rat cardiomyocytes. Cell Biol Int 31:1345-1352
9. Hilfinker-Kleiner D, Landmesser U, Drexler H (2006) Molecular Mechanisms in Heart Failure. J Am Coll Cardiol 48: A56-A66
10. Hunter JJ, Chien KR (1999) Signaling pathways for cardiac hypertrophy and failure. N Engl J Med 341:1276-1283
11. Karmazyn M, Liu Q, Gan XT, Brix BJ, Fliegel L (2003) Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes. Hypertension 42:1171-1176
12. Kobayashi N, Yoshida K, Nakano S, Ohno T, Honda T, Tsubokou Y, Matsuoka H (2006) Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts. Hypertension 47:671-679
13. Levkau B, Schafers M, Wohlschlaeger J, von Wnuck Lipinski K, Keul P, Hermann S, Kawaguchi N, Kirchhof P, Fabritz L, Stypmann J, Stegger L, Flogel U, Schrader J, Fischer JW, Hsieh P, Ou YL, Mehrhof F, Tiemann K, Ghanem A, Matus M, Neumann J, Heusch G, Schmid KW, Conway EM, Baba HA (2008) Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation 117:1583-1593
14. Lin Y, Wang LN, Xi YH, Li HZ, Xiao FG, Zhao YJ, Tian Y, Yang BF, Xu CQ (2008) L-arginine inhibits isoproterenol-induced cardiac hypertrophy through nitric oxide and polyamine pathways. Basic Clin Pharmacol Toxicol 103:124-130
15. Mano A, Tatsumi T, Shiraishi J, Keira N, Nomura T, Takeda M, Nishikawa S, Yamanaka S, Matoba S, Kobara M, Tanaka H, Shirayama T, Takamatsu T, Nozawa Y, Matsubara H (2004) Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways. Circulation 110:317-323
16. Nisenberg O, Pegg AE, Welsh PA, Keefer K, Shantz LM (2006) Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice. Biochem J 393:295-302
17. Okoshi MP, Yan X, Okoshi K, Nakayama M, Schuldt AJ, O'Connell TD, Simpson PC, Lorell BH (2004) Aldosterone directly stimulates cardiac myocyte hypertrophy. J Card Fail 10:511-518
18. Pignatti C, Tantini B, Stefanelli C, Flamigni F (2004) Signal transduction pathways linking polyamines to apoptosis. Amino Acids 27:359-365
19. Pikkarainen S, Tokola H, Kerkela R, Ruskoaho H (2004) GATA transcription factors in the developing and adult heart. Cardiovasc Res 63:196-207
20. Ryu JH, Cho YS, Chun YS, Park JW (2008) Myocardial SSAT induction via AMPK signaling and its implication for ischemic injury. Biochem Biophys Res Commun 366:438-444
21. Seiler N, Raul F (2005) Polyamines and apoptosis. J Cell Mol Med 9:623-642
22. Shantz LM, Feith DJ, Pegg AE (2001) Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonistinduced cardiac hypertrophy. Biochem J 358:25-32
23. Stanic I, Facchini A, Borzi RM, Vitellozzi R, Stefanelli C, Goldring MB, Guarnieri C, Facchini A, Flamigni F (2006) Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha. J Cell Physiol 206:138-146
24. Stanic I, Facchini A, Borzi RM, Stefanelli C, Flamigni F (2009) The polyamine analogue N1, N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines. J Cell Physiol 219:109-116
25. Stefanelli C, Pignatti C, Tantini B, Fattori M, Stanic I, Mackintosh CA, Flamigni F, Guarnieri C, Caldarera CM, Pegg AE (2001) Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells. Biochem J 355:199-206
26. Tanaka K, Ashizawa N, Kawano H, Sato O, Seto S, Nishihara E, Terazono H, Isomoto S, Shinohara K, Yano K (2007) Aldosterone induces circadian gene expression of clock genes in H9c2 cardiomyoblasts. Heart Vessels 22:254-260
27. Tantini B, Fiumana E, Cetrullo S, Pignatti C, Bonavita F, Shantz LM, Giordano E, Muscari C, Flamigni F, Guarnieri C, Stefanelli C, Caldarera CM (2006) Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia. J Mol Cell Cardiol 40:775-782
28. Tipnis UR, Gentry JB, Gutkowska J (1993) Effect of difluoromethylornithine on atrial natriuretic peptide in rat atria. Regul Pept 43:157-167
29. Tipnis UR, Haile C, Boor PJ, Gutkowska J (1994) Polyamine regulation of atrial natriuretic peptide in cultured cardiocytes. Regul Pept 52:75-84
30. Wang Y, Casero RA Jr (2006) Mammalian polyamine catabolism: a therapeutic target, a pathological problem, or both? J Biochem (Tokyo) 139:17-25
31. Zhao YJ, Xu CQ, Zhang WH, Zhang L, Bian SL, Huang Q, Sun HL, Li QF, Zhang YQ, Tian Y, Wang R, Yang BF, Li WM (2007) Role of polyamines in myocardial ischemia/reperfusion injury and their interactions with nitric oxide. Eur J Pharmacol 562:236-246