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Volumn 97, Issue 5, 2010, Pages 535-545

Molecular targeted therapies in small-cell lung cancer;Thérapies moléculaires ciblées dans le cancer du poumon à petites cellules

Author keywords

Small cell lung cancer; Targeted therapy

Indexed keywords

2 [[1 (7 CHLORO 4 QUINOLINYL) 5 (2,6 DIMETHOXYPHENYL) 3 PYRAZOLYL]CARBONYLAMINO] 2 ADAMANTANECARBOXYLIC ACID; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; AFINITOR; BEVACIZUMAB; BORTEZOMIB; CARBOPLATIN; CEDIRANIB; CISPLATIN; CYCLOPHOSPHAMIDE; DASATINIB; DEHYDRODIDEMNIN B; DOXORUBICIN; ETOPOSIDE; EVEROLIMUS; GEFITINIB; IMATINIB; IRINOTECAN; LENALIDOMIDE; MARIMASTAT; MECLINERTANT; N (5 CHLORO 1,3 BENZODIOXOL 4 YL) 7 [2 (4 METHYL 1 PIPERAZINYL)ETHOXY] 5 (TETRAHYDRO 2H PYRAN 4 YLOXY) 4 QUINAZOLINAMINE; OBATOCLAX; OBLIMERSEN; PACLITAXEL; PLACEBO; SORAFENIB; TEMSIROLIMUS; THALIDOMIDE; TIPIFARNIB; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR;

EID: 77953059217     PISSN: 00074551     EISSN: 17696917     Source Type: Journal    
DOI: 10.1684/bdc.2010.1035     Document Type: Review
Times cited : (4)

References (63)
  • 1
    • 34247560762 scopus 로고    scopus 로고
    • American Cancer Society, Atlanta : American Cancer Society
    • American Cancer Society, Cancer facts and figures. Atlanta : American Cancer Society, 2007.
    • (2007) Cancer Facts and Figures
  • 2
    • 33846013518 scopus 로고    scopus 로고
    • Temporal trends in small-cell lung cancer: Analysis of the National surveillance, epidemiology and end-results (SEER) database
    • Abstract 7082
    • Navada S, Lai P, Schwartz A, Kalemkerian G. Temporal trends in small-cell lung cancer: analysis of the National surveillance, epidemiology and end-results (SEER) database. J Clin Oncol 2006; 24: 18S: (Abstract 7082).
    • (2006) J Clin Oncol , vol.24
    • Navada, S.1    Lai, P.2    Schwartz, A.3    Kalemkerian, G.4
  • 3
    • 0035925071 scopus 로고    scopus 로고
    • Etoposide plus cisplatin with or without the combination of 4′-epidoxorubicin plus cyclophosphamide in treatment of extensive small-cell lung cancer: A French Federation of Cancer Institutes multicenter phase III randomized study
    • Pujol JL, Daurès JP, Rivière A, Quoix E, Westeel V, Quantin X, et al. Etoposide plus cisplatin with or without the combination of 4′-epidoxorubicin plus cyclophosphamide in treatment of extensive small-cell lung cancer: a French Federation of Cancer Institutes multicenter phase III randomized study. J Natl Cancer Inst 2001; 21: 300-308
    • (2001) J Natl Cancer Inst , vol.21 , pp. 300-308
    • Pujol, J.L.1    Daurès, J.P.2    Rivière, A.3    Quoix, E.4    Westeel, V.5    Quantin, X.6
  • 4
    • 60849117527 scopus 로고    scopus 로고
    • Evaluation of the use of prophylactic cranial irradiation in small-cell lung cancer
    • Patel S, Macdonald OK, Suntharalingam M. Evaluation of the use of prophylactic cranial irradiation in small-cell lung cancer. Cancer 2009; 15: 842-850
    • (2009) Cancer , vol.15 , pp. 842-850
    • Patel, S.1    Macdonald, O.K.2    Suntharalingam, M.3
  • 5
    • 33947582831 scopus 로고    scopus 로고
    • A review of first-line treatment for small-cell lung cancer
    • PII 0124389420060300000014
    • Murray N, Turrisi 3rd AT. A review of first-line treatment for small-cell lung cancer. J Thorac Oncol 2006; 1: 270-278 (Pubitemid 47181446)
    • (2006) Journal of Thoracic Oncology , vol.1 , Issue.3 , pp. 270-278
    • Murray, N.1    Turrisi III, A.T.2
  • 6
    • 0025323953 scopus 로고
    • A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro
    • Woll PJ, Rozengurt E. A neuropeptide antagonist that inhibits the growth of small-cell lung cancer in vitro. Cancer Res 1990; 50: 3968-3973 (Pubitemid 20225615)
    • (1990) Cancer Research , vol.50 , Issue.13 , pp. 3968-3973
    • Woll, P.J.1    Rozengurt, E.2
  • 7
    • 40749147725 scopus 로고    scopus 로고
    • Essential role of Pyk2 and Src kinase activation in neuropeptide-induced proliferation of small cell lung cancer cells
    • DOI 10.1038/sj.onc.1210819, PII 1210819
    • Roelle S, Grosse R, Buech T, Chubanov V, Gudermann T. Essential role of Pyk2 and Src-kinase activation in neuropeptide-induced proliferation of small-cell lung cancer cells. Oncogene 2008; 27: 1737-1748 (Pubitemid 351380271)
    • (2008) Oncogene , vol.27 , Issue.12 , pp. 1737-1748
    • Roelle, S.1    Grosse, R.2    Buech, T.3    Chubanov, V.4    Gudermann, T.5
  • 8
    • 0141988690 scopus 로고    scopus 로고
    • C-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions
    • Ma PC, Kijima T, Maulik G, Fox EA, Sattler M, Griffin JD, et al. c-MET mutational analysis in small-cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res 2003; 63: 6272-6281 (Pubitemid 37255174)
    • (2003) Cancer Research , vol.63 , Issue.19 , pp. 6272-6281
    • Ma, P.C.1    Kijima, T.2    Maulik, G.3    Fox, E.A.4    Sattler, M.5    Griffin, J.D.6    Johnson, B.E.7    Salgia, R.8
  • 9
    • 58149354871 scopus 로고    scopus 로고
    • Everolimus (RAD001) and solid tumours: A 2008 summary
    • Lévy A, Sauvin LA, Massard C, Soria JC. Everolimus (RAD001) and solid tumours: a 2008 summary. Bull Cancer 2008; 95: 1205-1211
    • (2008) Bull Cancer , vol.95 , pp. 1205-1211
    • Lévy, A.1    Sauvin, L.A.2    Massard, C.3    Soria, J.C.4
  • 10
    • 66149147044 scopus 로고    scopus 로고
    • Concurrent upregulation of Bcl-xl and Bcl-2A1 induces ∼1000-fold resistance to ABT-737 in chronic lymphocytic leukemia
    • Vogler M, Butterworth M, Dyer MJ, Cohen GM, et al. Concurrent upregulation of Bcl-xl and Bcl-2A1 induces ∼1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Blood 2009; 113: 4403-4413
    • (2009) Blood , vol.113 , pp. 4403-4413
    • Vogler, M.1    Butterworth, M.2    Dyer, M.J.3    Cohen, G.M.4
  • 11
    • 0032818149 scopus 로고    scopus 로고
    • Is small-cell lung cancer the perfect target for anti-telomerase treatment?
    • Sarvesvaran J, Going JJ, Milroy R, Kaye SB, Keith WN. Is small-cell lung cancer the perfect target for anti-telomerase treatment? Carcinogenesis 1999; 20: 1649-1651
    • (1999) Carcinogenesis , vol.20 , pp. 1649-1651
    • Sarvesvaran, J.1    Going, J.J.2    Milroy, R.3    Kaye, S.B.4    Keith, W.N.5
  • 13
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes: The Achilles heal of cancer
    • Weinstein IB. Cancer. Addiction to oncogenes: the Achilles heal of cancer. Science 2002; 297: 63-64
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 16
    • 27744567206 scopus 로고    scopus 로고
    • A phase II trial of imatinib (ST1571) in patients with c-Kit expressing relapsed small-cell lung cancer: A CALGB and NCCTG study
    • Dy GK, Miller AA, Mandrekar SJ, Aubry MC, Langdon Jr RM, Morton RF, et al. A phase II trial of imatinib (ST1571) in patients with c-Kit expressing relapsed small-cell lung cancer: a CALGB and NCCTG study. Ann Oncol 2005; 16: 1811-1816.
    • (2005) Ann Oncol , vol.16 , pp. 1811-1816
    • Dy, G.K.1    Miller, A.A.2    Mandrekar, S.J.3    Aubry, M.C.4    Langdon Jr., R.M.5    Morton, R.F.6
  • 17
    • 18044381919 scopus 로고    scopus 로고
    • Imatinib mesylate lacks activity in small-cell lung carcinoma expressing c-Kit protein: A phase II clinical trial
    • Krug LM, Crapanzano JP, Azzoli CG, Miller VA, Rizvi N, Gomez J, et al. Imatinib mesylate lacks activity in small-cell lung carcinoma expressing c-Kit protein: a phase II clinical trial. Cancer 2005; 103: 2128-2131
    • (2005) Cancer , vol.103 , pp. 2128-2131
    • Krug, L.M.1    Crapanzano, J.P.2    Azzoli, C.G.3    Miller, V.A.4    Rizvi, N.5    Gomez, J.6
  • 18
    • 34147154400 scopus 로고    scopus 로고
    • Phase II trial of imatinib maintenance therapy after irinotecan and cisplatin in patients with c-Kit positive extensive-stage small-cell lung cancer (ES CBPC)
    • Schneider B, Gadgeel S, Ramnath N, et al. Phase II trial of imatinib maintenance therapy after irinotecan and cisplatin in patients with c-Kit positive extensive-stage small-cell lung cancer (ES CBPC). J Clin Oncol 2006; 24: 17089.
    • (2006) J Clin Oncol , vol.24 , pp. 17089
    • Schneider, B.1    Gadgeel, S.2    Ramnath, N.3
  • 19
    • 34548553041 scopus 로고    scopus 로고
    • Combination of SN-38 with gefitinib or imatinib overcomes SN-38-resistant small-cell lung cancer cells
    • Takigawa N, Takeyama M, Kozuki T, Shibayama T, Hisamoto A, Kiura K, et al. Combination of SN-38 with gefitinib or imatinib overcomes SN-38-resistant small-cell lung cancer cells. Oncol Rep 2007; 17: 983-987
    • (2007) Oncol Rep , vol.17 , pp. 983-987
    • Takigawa, N.1    Takeyama, M.2    Kozuki, T.3    Shibayama, T.4    Hisamoto, A.5    Kiura, K.6
  • 20
    • 30744452995 scopus 로고    scopus 로고
    • Phase I studies of imatinib mesylate combined with cisplatin and irinotecan in patients with small cell lung carcinoma
    • DOI 10.1002/cncr.21640
    • Johnson FM, Krug LM, Tran HT, Shoaf S, Prieto V, Tamboli P, et al. Phase I studies of imatinib mesylate combined with cisplatin and irinotecan in patients with small-cell lung carcinoma. Cancer 2006; 106: 366-374 (Pubitemid 43100446)
    • (2006) Cancer , vol.106 , Issue.2 , pp. 366-374
    • Johnson, F.M.1    Krug, L.M.2    Tran, H.T.3    Shoaf, S.4    Prieto, V.G.5    Tamboli, P.6    Peeples, B.7    Patel, J.8    Glisson, B.S.9
  • 21
    • 34548407704 scopus 로고    scopus 로고
    • Irinotecan, carboplatin and imatinib in untreated extensive-stage small-cell lung cancer: A phase II trial of the Minnie Pearl Cancer Research Network
    • Spigel DR, Hainsworth JD, Simons L, Meng C, Burris 3rd HA, Yardley DA, et al. Irinotecan, carboplatin and imatinib in untreated extensive-stage small-cell lung cancer: a phase II trial of the Minnie Pearl Cancer Research Network. J Thorac Oncol 2007; 2: 54-861.
    • (2007) J Thorac Oncol , vol.2 , pp. 54-861
    • Spigel, D.R.1    Hainsworth, J.D.2    Simons, L.3    Meng, C.4    Burris III, H.A.5    Yardley, D.A.6
  • 22
    • 45749084492 scopus 로고    scopus 로고
    • New Bcr-Abl inhibitors in chronic myeloid leukemia: Keeping resistance in check
    • DOI 10.1517/13543784.17.6.865
    • O'Hare T, Eide CA, Deininger MW. New Bcr-Abl inhibitors in chronic myeloid leukemia: keeping resistance in check. Expert Opin Investig Drugs 2008; 17: 865-878 (Pubitemid 351864324)
    • (2008) Expert Opinion on Investigational Drugs , vol.17 , Issue.6 , pp. 865-878
    • O'Hare, T.1    Eide, C.A.2    Deininger, M.W.3
  • 23
    • 33745906506 scopus 로고    scopus 로고
    • Clinical development of Src tyrosine kinase inhibitors in lung cancer
    • Lee D, Gautschi O. Clinical development of SRC tyrosine-kinase inhibitors in lung cancer. Clin Lung Cancer 2006; 7: 381-384 (Pubitemid 44043546)
    • (2006) Clinical Lung Cancer , vol.7 , Issue.6 , pp. 381-384
    • Lee, D.1    Gautschi, O.2
  • 24
    • 34249779568 scopus 로고    scopus 로고
    • Global ARCC Trial. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, et al. Global ARCC Trial. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356: 2271-2281
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3    Dutcher, J.4    Figlin, R.5    Kapoor, A.6
  • 25
    • 4444236880 scopus 로고    scopus 로고
    • Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer
    • Heymach JV, Johnson DH, Khuri FR, Safran H, Schlabach LL, Yunus F, et al. Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer. Ann Oncol 2004; 15: 1187-1193
    • (2004) Ann Oncol , vol.15 , pp. 1187-1193
    • Heymach, J.V.1    Johnson, D.H.2    Khuri, F.R.3    Safran, H.4    Schlabach, L.L.5    Yunus, F.6
  • 26
    • 33644770041 scopus 로고    scopus 로고
    • Gefitinib in patients with chemo-sensitive and chemo-refractory relapsed small cell cancers: A Hoosier Oncology Group phase II trial
    • DOI 10.1016/j.lungcan.2005.12.002, PII S0169500206000213
    • Moore AM, Einhorn LH, Estes D, Govindan R, Axelson J, Vinson J, et al. Gefitinib in patients with chemosensitive and chemorefractory relapsed small-cell cancers: a Hoosier Oncology Group phase II trial. Lung Cancer 2006; 52: 93-97 (Pubitemid 43340205)
    • (2006) Lung Cancer , vol.52 , Issue.1 , pp. 93-97
    • Moore, A.M.1    Einhorn, L.H.2    Estes, D.3    Govindan, R.4    Axelson, J.5    Vinson, J.6    Breen, T.E.7    Yu, M.8    Hanna, N.H.9
  • 27
  • 28
    • 35848959875 scopus 로고    scopus 로고
    • A randomized, phase II trial of two dose levels of temsirolimus (CCI-779) in patients with extensive-stage small-cell lung cancer who have responding or stable disease after induction chemotherapy: A trial of the Eastern Cooperative Oncology Group (E1500)
    • DOI 10.1097/JTO.0b013e318155a439, PII 0124389420071100000009
    • Pandya KJ, Dahlberg S, Hidalgo M, Cohen RB, Lee MW, Schiller JH, et al. A randomized, phase II trial of two dose levels of temsirolimus (CCI-779) in patients with extensive-stage small-cell lung cancer who have responding or stable disease after induction chemotherapy: a trial of the Eastern Cooperative Oncology Group (E1500). J Thorac Oncol 2007; 2: 1036-1041 (Pubitemid 350059580)
    • (2007) Journal of Thoracic Oncology , vol.2 , Issue.11 , pp. 1036-1041
    • Pandya, K.J.1    Dahlberg, S.2    Hidalgo, M.3    Cohen, R.B.4    Lee, M.W.5    Schiller, J.H.6    Johnson, D.H.7
  • 30
    • 0036236808 scopus 로고    scopus 로고
    • A pilot trial of G3139, a Bcl-2 antisense oligonucleotide and paclitaxel in patients with chemorefractory small-cell lung cancer
    • Rudin CM, Otterson GA, Mauer AM, Villalona, Calero MA, Tomek R, et al. A pilot trial of G3139, a Bcl-2 antisense oligonucleotide and paclitaxel in patients with chemorefractory small-cell lung cancer. Ann Oncol 2007; 13: 539-545
    • (2007) Ann Oncol , vol.13 , pp. 539-545
    • Rudin, C.M.1    Otterson, G.A.2    Mauer, A.M.3    Villalona4    Calero, M.A.5    Tomek, R.6
  • 31
    • 1842562213 scopus 로고    scopus 로고
    • Phase I study of G3139, a Bcl-2 antisense oligonucleotide, combined with carboplatin and etoposide in patients with small-cell lung cancer
    • Rudin CM, Kozloff M, Hoffman P, Edelman MJ, Karnauskas R, Tomek R, et al. Phase I study of G3139, a Bcl-2 antisense oligonucleotide, combined with carboplatin and etoposide in patients with small-cell lung cancer. J Clin Oncol 2004; 22: 1110-1117
    • (2004) J Clin Oncol , vol.22 , pp. 1110-1117
    • Rudin, C.M.1    Kozloff, M.2    Hoffman, P.3    Edelman, M.J.4    Karnauskas, R.5    Tomek, R.6
  • 32
    • 39749166555 scopus 로고    scopus 로고
    • Randomized phase II Study of carboplatin and etoposide with or without the Bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103
    • Rudin CM, Salgia R, Wang X, Hodgson LD, Masters GA, Green M, et al. Randomized phase II Study of carboplatin and etoposide with or without the Bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103. J Clin Oncol 2008; 26: 870-876
    • (2008) J Clin Oncol , vol.26 , pp. 870-876
    • Rudin, C.M.1    Salgia, R.2    Wang, X.3    Hodgson, L.D.4    Masters, G.A.5    Green, M.6
  • 33
    • 37249057877 scopus 로고    scopus 로고
    • A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small-cell lung cancer cells
    • Li J, Viallet J, Haura EB. A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small-cell lung cancer cells. Cancer Chemother Pharmacol 2008; 61: 525-534
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 525-534
    • Li, J.1    Viallet, J.2    Haura, E.B.3
  • 35
    • 34247855046 scopus 로고    scopus 로고
    • Bortezomib (PS-341) in relapsed or refractory extensive stage small-cell lung cancer: A Southwest Oncology Group phase II trial (S0327)
    • Lara PN Jr, Chansky K, Davies AM, Franklin WA, Gumerlock PH, Guaglianone PP, et al. Bortezomib (PS-341) in relapsed or refractory extensive stage small-cell lung cancer: a Southwest Oncology Group phase II trial (S0327). J Thorac Oncol 2006: 996-1001.
    • (2006) J Thorac Oncol , pp. 996-1001
    • Lara Jr., P.N.1    Chansky, K.2    Davies, A.M.3    Franklin, W.A.4    Gumerlock, P.H.5    Guaglianone, P.P.6
  • 36
    • 0346036093 scopus 로고    scopus 로고
    • Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK and p38 MAPK
    • Cuadrado A, Garcia-Fernandez LF, Gonzalez L, Suarez Y, Losada A, Alcaide V, et al. Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK and p38 MAPK. J Biol Chem 2003; 278: 241-250
    • (2003) J Biol Chem , vol.278 , pp. 241-250
    • Cuadrado, A.1    Garcia-Fernandez, L.F.2    Gonzalez, L.3    Suarez, Y.4    Losada, A.5    Alcaide, V.6
  • 37
  • 38
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 40
    • 23844511435 scopus 로고    scopus 로고
    • Irinotecan (I), carboplatin (C), and radiotherapy (RT) followed by bevacizumab (B) in the treatment of limited-stage small-cell lung cancer (CBPC): A phase II trial of the Minnie Pearl Cancer Research Network
    • Raefsky E, Spigel DR, Greco FA, Petrone D, Hainsworth JD, et al. Irinotecan (I), carboplatin (C), and radiotherapy (RT) followed by bevacizumab (B) in the treatment of limited-stage small-cell lung cancer (CBPC): a phase II trial of the Minnie Pearl Cancer Research Network. Proc Am Soc Clin Oncol 2005; 23: 7050.
    • (2005) Proc Am Soc Clin Oncol , vol.23 , pp. 7050
    • Raefsky, E.1    Spigel, D.R.2    Greco, F.A.3    Petrone, D.4    Hainsworth, J.D.5
  • 41
    • 49749118333 scopus 로고    scopus 로고
    • Available at
    • Barron H, MedWatch safety alert 2007. Available at: http://www.fda.gov/ downloads/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ UCM153953.pdf
    • (2007) MedWatch Safety Alert
    • Barron, H.1
  • 42
    • 34147150440 scopus 로고    scopus 로고
    • Irinotecan (I), carboplatin (C) and radiotherapy (RT) followed by maintenance bevacizumab (B) in the treatment (tx) of limited-stage small-cell lung cancer (LSSCLC): Update of a phase II trial of the Minnie Pearl Cancer Research Network
    • abstract
    • Patton JF, Spigel DR, Greco FA, et al. Irinotecan (I), carboplatin (C) and radiotherapy (RT) followed by maintenance bevacizumab (B) in the treatment (tx) of limited-stage small-cell lung cancer (LSSCLC): update of a phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol 2006; 24: 385s (abstract).
    • (2006) J Clin Oncol , vol.24
    • Patton, J.F.1    Spigel, D.R.2    Greco, F.A.3
  • 43
    • 49749131985 scopus 로고    scopus 로고
    • CALGB 30306: A phase II study of cisplatin (C), irinotecan (I) and bevacizumab (B) for untreated extensive stage small-cell lung cancer (ES-CBPC)
    • Ready N, Dudek AZ, Wang XF, et al. CALGB 30306: a phase II study of cisplatin (C), irinotecan (I) and bevacizumab (B) for untreated extensive stage small-cell lung cancer (ES-CBPC). Proc Am Soc Clin Oncol 2007; 25: 7563.
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 7563
    • Ready, N.1    Dudek, A.Z.2    Wang, X.F.3
  • 44
    • 37749048789 scopus 로고    scopus 로고
    • A phase II study of cisplatin (P) plus etoposide (E) plus bevacizumab (B) for previously untreated extensive stage small-cell lung cancer (CBPC) (E3501): A trial of the Eastern Cooperative Oncology Group
    • Sandler A, Szwaric S, Dowlati A, et al. A phase II study of cisplatin (P) plus etoposide (E) plus bevacizumab (B) for previously untreated extensive stage small-cell lung cancer (CBPC) (E3501): a trial of the Eastern Cooperative Oncology Group. Proc Am Soc Clin Oncol 2007; 25: 7564.
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 7564
    • Sandler, A.1    Szwaric, S.2    Dowlati, A.3
  • 45
    • 37749007862 scopus 로고    scopus 로고
    • Phase II trial of irinotecan, carboplatin and bevacizumab in patients with extensive-stage small-cell lung cancer
    • Spigel D, Hainsworth JD, Saez R, Greco FA, et al. Phase II trial of irinotecan, carboplatin and bevacizumab in patients with extensive-stage small-cell lung cancer. Proc Am Soc Clin Oncol 2007; 25: 18130.
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 18130
    • Spigel, D.1    Hainsworth, J.D.2    Saez, R.3    Greco, F.A.4
  • 47
    • 34548538283 scopus 로고    scopus 로고
    • Phase III double-blind, placebo-controlled study of thalidomide in extensive-disease small-cell lung cancer after response to chemotherapy: An intergroup study FNCLCC cleo04 IFCT 00-01
    • Pujol JL, Breton JL, Gervais R, Tanguy ML, Quoix E, David P, et al. Phase III double-blind, placebo-controlled study of thalidomide in extensive-disease small-cell lung cancer after response to chemotherapy: an intergroup study FNCLCC cleo04 IFCT 00-01. J Clin Oncol 2007; 25: 3945-3951
    • (2007) J Clin Oncol , vol.25 , pp. 3945-3951
    • Pujol, J.L.1    Breton, J.L.2    Gervais, R.3    Tanguy, M.L.4    Quoix, E.5    David, P.6
  • 48
    • 37349086947 scopus 로고    scopus 로고
    • A phase III randomised, double blind, placebo controlled trial of etoposide/carboplatin with or without thalidomide in advanced small-cell lung cancer (CBPC)
    • Lee SW, Woll PJ, James LE, Ali SR, Hackshaw A, et al. A phase III randomised, double blind, placebo controlled trial of etoposide/carboplatin with or without thalidomide in advanced small-cell lung cancer (CBPC). J Thor Oncol 2007; 2: S306.
    • (2007) J Thor Oncol , vol.2
    • Lee, S.W.1    Woll, P.J.2    James, L.E.3    Ali, S.R.4    Hackshaw, A.5
  • 49
    • 34247847775 scopus 로고    scopus 로고
    • Phase II trial of thalidomide as maintenance therapy for extensive stage small-cell lung cancer after response to chemotherapy
    • Dowlati A, Subbiah S, Cooney M, Rutherford K, Mekhail T, Fu P, et al. Phase II trial of thalidomide as maintenance therapy for extensive stage small-cell lung cancer after response to chemotherapy. Lung Cancer 2007; 56: 377-381
    • (2007) Lung Cancer , vol.56 , pp. 377-381
    • Dowlati, A.1    Subbiah, S.2    Cooney, M.3    Rutherford, K.4    Mekhail, T.5    Fu, P.6
  • 50
    • 0037112183 scopus 로고    scopus 로고
    • Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: A trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer
    • Shepherd FA, Giaccone G, Seymour L, Debruyne C, Bezjak A, Hirsh V, et al. Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: a trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer. J Clin Oncol 2002; 20: 4434-4439
    • (2002) J Clin Oncol , vol.20 , pp. 4434-4439
    • Shepherd, F.A.1    Giaccone, G.2    Seymour, L.3    Debruyne, C.4    Bezjak, A.5    Hirsh, V.6
  • 51
    • 40849118632 scopus 로고    scopus 로고
    • Vandetanib in metastatic hereditary medullary thyroid cancer: Follow-up results of an open-label phase II trial
    • ASCO Annual Meeting Proceedings Part I
    • Wells S, Gosnell J, Gagel R, et al. Vandetanib in metastatic hereditary medullary thyroid cancer: follow-up results of an open-label phase II trial. J Clin Oncol 2007. ASCO Annual Meeting Proceedings Part I. Vol 25, no 18S, 2007: 6018.
    • (2007) J Clin Oncol 2007 , vol.25 , Issue.18 S , pp. 6018
    • Wells, S.1    Gosnell, J.2    Gagel, R.3
  • 52
    • 34948844052 scopus 로고    scopus 로고
    • Phase II study of vandetanib or placebo in small-cell lung cancer patients after complete or partial response to induction chemotherapy with or without radiation therapy: National Cancer Institute of Canada Clinical Trials Group Study BR.20
    • Arnold AM, Seymour L, Smylie M, et al. Phase II study of vandetanib or placebo in small-cell lung cancer patients after complete or partial response to induction chemotherapy with or without radiation therapy: National Cancer Institute of Canada Clinical Trials Group Study BR.20. J Clin Oncol 2007; 25: 4278-4284
    • (2007) J Clin Oncol , vol.25 , pp. 4278-4284
    • Arnold, A.M.1    Seymour, L.2    Smylie, M.3
  • 53
    • 49749137912 scopus 로고    scopus 로고
    • Sorafenib in patients with platinum (plat) treated extensive stage small-cell lung cancer (E-CBPC): A SWOG (S0435) phase II trial
    • Gitlitz BJ, Glisson BS, Moon J, et al. Sorafenib in patients with platinum (plat) treated extensive stage small-cell lung cancer (E-CBPC): a SWOG (S0435) phase II trial. Proc Am Soc Clin Onco 2008; 26: 8039.
    • (2008) Proc Am Soc Clin Onco , vol.26 , pp. 8039
    • Gitlitz, B.J.1    Glisson, B.S.2    Moon, J.3
  • 54
    • 49749108603 scopus 로고    scopus 로고
    • Cediranib (AZD2171) for the treatment of recurrent small-cell lung cancer (SCLC): A California consortium phase II study (NCI # 7097)
    • Ramalingam S. Cediranib (AZD2171) for the treatment of recurrent small-cell lung cancer (SCLC): a California consortium phase II study (NCI # 7097). ASCO Meeting Abstracts 2008; 26: 8078.
    • ASCO Meeting Abstracts 2008 , vol.26 , pp. 8078
    • Ramalingam, S.1
  • 55
    • 0028792251 scopus 로고
    • Role of recombinant interferon alfa-2a maintenance in patients with limited-stage small-cell lung cancer responding to concurrent chemoradiation: A Southwest Oncology Group study
    • Kelly K, Crowley JJ, Bunn Jr PA, Hazuka MB, Beasley K, Upchurch C, et al. Role of recombinant interferon alfa-2a maintenance in patients with limited-stage small-cell lung cancer responding to concurrent chemoradiation: a Southwest Oncology Group study. J Clin Oncol 1995; 13: 2924-2930
    • (1995) J Clin Oncol , vol.13 , pp. 2924-2930
    • Kelly, K.1    Crowley, J.J.2    Bunn Jr., P.A.3    Hazuka, M.B.4    Beasley, K.5    Upchurch, C.6
  • 56
    • 27244446896 scopus 로고    scopus 로고
    • Phase III study of adjuvant vaccination with Bec 2/bacille Calmette Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study)
    • Giaccone G, Debruyne C, Felip E, Chapman PB, Grant SC, Millward M, et al. Phase III study of adjuvant vaccination with Bec 2/bacille Calmette Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study). J Clin Oncol 2005; 23: 6854-6864
    • (2005) J Clin Oncol , vol.23 , pp. 6854-6864
    • Giaccone, G.1    Debruyne, C.2    Felip, E.3    Chapman, P.B.4    Grant, S.C.5    Millward, M.6
  • 57
    • 0347281391 scopus 로고    scopus 로고
    • Addition of SRL172 (Mycobacterium Vaccae) to standard chemotherapy in small-cell lung cancer (SCLC) confers no survival benefit: Results of a randomized multicenter study
    • abstract
    • Harper-Wynne CL, Sumpter K, O'Brien MER, et al. Addition of SRL172 (Mycobacterium Vaccae) to standard chemotherapy in small-cell lung cancer (SCLC) confers no survival benefit: results of a randomized multicenter study. Lung Cancer 2003; 41: S181 (abstract).
    • (2003) Lung Cancer , vol.41
    • Harper-Wynne, C.L.1    Sumpter, K.2    O'Brien, M.E.R.3
  • 59
    • 49749096776 scopus 로고    scopus 로고
    • Update on targeted therapies for small-cell carcinoma of the lung
    • Griffiths R, Lorigan P, Thatcher N, Blackhall F. Update on targeted therapies for small-cell carcinoma of the lung. Targ oncol 2008; 3: 205-215
    • (2008) Targ Oncol , vol.3 , pp. 205-215
    • Griffiths, R.1    Lorigan, P.2    Thatcher, N.3    Blackhall, F.4
  • 61
    • 34547558390 scopus 로고    scopus 로고
    • Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: Implications for tumour invasion
    • DOI 10.1038/sj.bjc.6603884, PII 6603884
    • Ma PC, Tretiakova MS, Nallasura V, Jagadeeswaran R, Husain AN, Salgia R. Downstream signalling and specific inhibition of c-MET/HGF pathway in small-cell lung cancer: implications for tumour invasion. Br J Cancer 2007; 97: 368-377 (Pubitemid 47196754)
    • (2007) British Journal of Cancer , vol.97 , Issue.3 , pp. 368-377
    • Ma, P.C.1    Tretiakova, M.S.2    Nallasura, V.3    Jagadeeswaran, R.4    Husain, A.N.5    Salgia, R.6
  • 63
    • 85031337155 scopus 로고    scopus 로고
    • Correlation between plasma cytokine/angiogenic factors (C/AF) and signaling pathways activation from baseline tumour biopsy specimens in patients with advanced non-small cell lung cancer (NSCLC): Preliminary analysis from the Biomarker-based Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) Clinical Study
    • Tran HT. Correlation between plasma cytokine/angiogenic factors (C/AF) and signaling pathways activation from baseline tumour biopsy specimens in patients with advanced non-small cell lung cancer (NSCLC): preliminary analysis from the Biomarker-based Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) Clinical Study. ASCO Meeting Abstracts 2008; 26: 8010.
    • ASCO Meeting Abstracts 2008 , vol.26 , pp. 8010
    • Tran, H.T.1


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