Multimodality imaging of myocardial injury and remodeling

Journal of Nuclear Medicine

Volumn 51, Issue SUPPL.1, 2010, Pages

  Kramer, Christopher M ^a   Sinusas, Albert J ^b   Sosnovik, David E ^c   French, Brent A ^a   Bengel, Frank M ^d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

MRI; Myocardial infarction; Noninvasive imaging; PET; Remodeling; SPECT

Indexed keywords

ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INTEGRIN; MATRIX METALLOPROTEINASE; TRACER; ANGIOTENSIN 1 RECEPTOR;

APOPTOSIS; CARDIAC IMAGING; CONGESTIVE HEART FAILURE; DIFFUSION TENSOR IMAGING; DISEASE COURSE; FLUORESCENCE IMAGING; HEART FAILURE; HEART INFARCTION; HEART MUSCLE INJURY; HEART VENTRICLE REMODELING; HUMAN; MACROPHAGE; MOLECULAR IMAGING; NERVOUS SYSTEM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYMPATHETIC INNERVATION; ULTRASOUND; ADRENERGIC SYSTEM; ANIMAL; CHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; HEART MUSCLE; METABOLISM; METHODOLOGY; PATHOLOGY; SPECTROFLUOROMETRY;

ANIMALS; HEART FAILURE; HUMANS; MACROPHAGES; MAGNETIC RESONANCE IMAGING; MYOCARDIAL INFARCTION; MYOCARDIUM; POSITRON-EMISSION TOMOGRAPHY; RECEPTOR, ANGIOTENSIN, TYPE 1; SPECTROMETRY, FLUORESCENCE; SYMPATHETIC NERVOUS SYSTEM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED; VENTRICULAR REMODELING;

EID: 77953057900     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.068221     Document Type: Review

References (88)

1. Sutton MG, Sharpe N. Left ventricular remodeling after myocardial infarction. Pathophysiology and therapy. Circulation. 2000;101:2981-2988.
2. Weber KT. Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation. Circulation. 1997;96:4065-4082.
3. Spinale FG. Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev. 2007;87:1285-1342.
4. Creemers EE, Davis JN, Parkhurst AM, et al. Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2003;284:H364-H371.
5. Mukherjee R, Mingoia JT, Bruce JA, et al. Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription following myocardial infarction. Am J Physiol Heart Circ Physiol. 2006;291:2216-2228.
6. Wilson EM, Moainie SL, Baskin JM, et al. Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling. Circulation. 2003;107:2857-2863.
7. Webb CS, Bonnema DD, Ahmed SH, et al. Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling. Circulation. 2006;114:1020-1027.
8. Chen J, Tung CH, Allport JR, Chen S, Weissleder R, Huang PL. Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction. Circulation. 2005;111:1800-1805.
9. Su H, Spinale FG, Dobrucki LW, et al. Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation. 2005;112:3157-3167.
10. Sahul Z, Song J, McAteer J, et al. Quantification of in-vivo matrix metalloproteinase activity and myocardial strain yield unique spatial temporal patterns in a porcine model of myocardial infarction [abstract]. Circulation. 2006;114:II-500.
11. Li S, Dobrucki LW, Sinusas AJ, Liu YH. A new method for SPECT quantification of targeted radiotracers uptake in the myocardium. Med Image Comput Comput Assist Interv. 2005;8:684-691.
12. Liu Y, Sahul Z, Weyman C, et al. Hotspot quantification of myocardial focal tracer uptake from molecular targeted SPECT/CT images: canine validation. Proc SPIE. 2008;6915:69150N1-8.
13. Paul M, Poyan Mehr A, Kreutz R. Physiology of local renin-angiotensin systems. Physiol Rev. 2006;86:747-803.
14. Shirani J, Dilsizian V. Imaging left ventricular remodeling: targeting the neurohumoral axis. Nat Clin Pract Cardiovasc Med. 2008;5(suppl 2):S57-S62.
15. Dilsizian V, Eckelman WC, Loredo ML, Jagoda EM, Shirani J. Evidence for tissue angiotensin-converting enzyme in explanted hearts of ischemic cardiomyopathy using targeted radiotracer technique. J Nucl Med. 2007;48:182-187.
16. Shirani J, Narula J, Eckelman WC, Narula N, Dilsizian V. Early imaging in heart failure: exploring novel molecular targets. J Nucl Cardiol. 2007;14:100-110.
17. Verjans JW, Lovhaug D, Narula N, et al. Noninvasive imaging of angiotensin receptors after myocardial infarction. JACC Cardiovasc Imaging. 2008;1:354-362.
18. Streeter DD Jr, Hanna WT. Engineering mechanics for successive states in canine left ventricular myocardium. II. Fiber angle and sarcomere length. Circ Res. 1973;33:656-664.
19. Streeter DD Jr, Spotnitz HM, Patel DP, Ross J Jr, Sonnenblick EH. Fiber orientation in the canine left ventricle during diastole and systole. Circ Res. 1969;24:339-347.
20. Buckberg G, Hoffman JI, Mahajan A, Saleh S, Coghlan C. Cardiac mechanics revisited: the relationship of cardiac architecture to ventricular function. Circulation. 2008;118:2571-2587.
21. Kramer CM. Insights into myocardial microstructure during infarct healing and remodeling: pathologists need not apply. Circ Cardiovasc Imaging. 2009;2:4-5.
22. Hagmann P, Jonasson L, Maeder P, Thiran JP, Wedeen VJ, Meuli R. Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. Radiographics. 2006;26(suppl 1):S205-S223.
23. Sosnovik DE, Wang R, Dai G, et al. Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging. 2009;2:206-212.
24. Wedeen VJ, Hagmann P, Tseng WY, Reese TG, Weisskoff RM. Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging. Magn Reson Med. 2005;54:1377-1386.
25. Sosnovik DE, Wang R, Dai G, Reese TG, Wedeen VJ. Diffusion MR tractography of the heart. J Cardiovasc Magn Reson. 2009;11:47.
26. Sosnovik DE, Nahrendorf M, Weissleder R. Molecular magnetic resonance imaging in cardiovascular medicine. Circulation. 2007;115:2076-2086. (Pubitemid 46625959)
27. Caravan P, Das B, Dumas S, et al. Collagen-targeted MRI contrast agent for molecular imaging of fibrosis. Angew Chem Int Ed Engl. 2007;46:8171-8173.
28. Spuentrup E, Ruhl KM, Botnar RM, et al.Molecular magnetic resonance imaging of myocardial perfusion with EP-3600, a collagen-specific contrast agent: initial feasibility study in a swine model. Circulation. 2009;119:1768-1775.
29. Helm PA, Caravan P, French BA, et al. Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agent. Radiology. 2008;247:788-796.
30. Sosnovik DE, Nahrendorf M, Weissleder R. Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications. Basic Res Cardiol. 2008;103:122-130.
31. Krombach GA, Wendland MF, Higgins CB, Saeed M. MR imaging of spatial extent of microvascular injury in reperfused ischemically injured rat myocardium: value of blood pool ultrasmall superparamagnetic particles of iron oxide. Radiology. 2002;225:479-486.
32. Sosnovik DE, Garanger E, Aikawa E, et al. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging. 2009;2:460-467.
33. Harisinghani MG, Barentsz J, Hahn PF, et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med. 2003;348:2491-2499. (Pubitemid 36706536)
34. Sosnovik DE, Nahrendorf M, Panizzi P, et al. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging. 2009;2:468-475.
35. Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L. Nanoparticle imaging of integrins on tumor cells. Neoplasia. 2006;8:214-222.
36. Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L. Multiparameter magnetic relaxation switch assays. Anal Chem. 2007;79:8863-8869.
37. Nahrendorf M, Swirski FK, Aikawa E, et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007;204:3037-3047.
38. Farrar CT, Dai G, Novikov M, et al. Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging. NMR Biomed. 2008;21:453-463.
39. Sosnovik DE, Nahrendorf M, Deliolanis N, et al. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation. 2007;115:1384-1391.
40. Sosnovik DE, Schellenberger EA, Nahrendorf M, et al. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005;54:718-724.
41. Chen JW, Querol Sans M, Bogdanov A Jr, Weissleder R. Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology. 2006;240:473-481.
42. Nahrendorf M, Sosnovik D, Chen JW, et al. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation. 2008;117:1153-1160.
43. Weissleder R, Ntziachristos V. Shedding light onto live molecular targets. Nat Med. 2003;9:123-128.
44. Mahmood U, Tung CH, Bogdanov A Jr, Weissleder R. Near-infrared optical imaging of protease activity for tumor detection. Radiology. 1999;213:866-870.
45. Graves EE, Ripoll J, Weissleder R, Ntziachristos V. A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Phys. 2003;30:901-911.
46. Deliolanis N, Lasser T, Hyde D, Soubret A, Ripoll J, Ntziachristos V. Free-space fluorescence molecular tomography utilizing 360 degrees geometry projections. Opt Lett. 2007;32:382-384.
47. Nahrendorf M, Sosnovik DE, Waterman P, et al. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res. 2007;100:1218-1225.
48. Vinegoni C, Razansky D, Figueiredo JL, et al. Born normalization for fluorescence optical projection tomography for whole heart imaging. Available at: http://www.jove.com/index/Details.stp?ID=1389. Accessed February 24, 2010.
49. Vinegoni C, Razansky D, Figueiredo JL, Nahrendorf M, Ntziachristos V, Weissleder R. Normalized Born ratio for fluorescence optical projection tomography. Opt Lett. 2009;34:319-321.
50. Yang Z, Berr SS, Gilson WD, Toufektsian M-C, French BA. Simultaneous evaluation of infarct size and cardiac function in intact mice by contrast-enhanced cardiac magnetic resonance imaging reveals contractile dysfunction in noninfarcted regions early after myocardial infarction. Circulation. 2004;109:1161-1167.
51. Ross AJ, Yang Z, Berr S, et al. Serial MRI evaluation of cardiac structure and function in mice after reperfused myocardial infarction. Magn Reson Med. 2002;47:1158-1168.
52. Gilson WD, Yang Z, French BA, Epstein FH. Measurement of myocardial mechanics in mice before and after infarction using multislice displacement-encoded MRI with 3D motion encoding. Am J Physiol Heart Circ Physiol. 2005;288:H1491-H1497.
53. Young AA, French BA, Yang Z, et al. Reperfused myocardial infarction in mice: 3D mapping of late gadolinium enhancement and strain. J Cardiovasc Magn Reson. 2006;8:685-692.
54. Chapon C, Herlihy A, Bhakoo K. Assessment of myocardial infarction in mice by late gadolinium enhancement MR imaging using an inversion recovery pulse sequence at 9.4T. J Cardiovasc Magn Reson. 2008;10:6.
55. Beyers R, Xu Y, Epstein F, French B. T2-weighted MRI pulse sequences for imaging post-infarct edema in mice: comparison of spin echo and T2 preparation approaches [abstract]. J Cardiovasc Magn Reson. 2009;11(suppl 1):O33.
56. Streif JUG, Nahrendorf M, Hiller K-H, et al. In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imaging. Magn Reson Med. 2005;53:584-592.
57. Kramer CM. Integrated approach to ischemic heart disease: the one-stop shop. Cardiol Clin. 1998;16:267-276.
58. Gilson WD, Epstein FH, Yang Z, et al. Borderzone contractile dysfunction is transiently attenuated and left ventricular structural remodeling is markedly reduced following reperfused myocardial infarction in inducible nitric oxide synthase knockout mice. J Am Coll Cardiol. 2007;50:1799-1807.
59. Nahrendorf M, Streif JU, Hiller K-H, et al. Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics. Am J Physiol Heart Circ Physiol. 2006;290:H2516-2521.
60. Timmers L, Sluijter JPG, van Keulen JK, et al. Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circ Res. 2008;102:257-264.
61. Yang Z, Bove CM, French BA, et al. Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction. Circulation. 2002;106:106-111.
62. Foster FS, Charles JP, Kasia AH, Donald AC, Daniel HT. Advances in ultrasound biomicroscopy. Ultrasound Med Biol. 2000;26:1-27.
63. Dawson D, Lygate CA, Saunders J, et al. Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice. Circulation. 2004;110:1632-1637.
64. Li Y, Garson CD, Xu Y, et al. Quantification and MRI validation of regional contractile dysfunction in mice post myocardial infarction using high resolution ultrasound. Ultrasound Med Biol. 2007;33:894-904. (Pubitemid 46809779)
65. French BA, Li Y, Klibanov AL, Yang Z, Hossack JA. 3D perfusion mapping in post-infarct mice using myocardial contrast echocardiography. Ultrasound Med Biol. 2006;32:805-815.
66. Ebert SN, Taylor DG, Nguyen H-L, et al. Noninvasive tracking of cardiac embryonic stem cells in vivo using magnetic resonance imaging techniques. Stem Cells. 2007;25:2936-2944.
67. Lindner JR, Song J, Xu F, et al. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation. 2000;102:2745-2750.
68. Villanueva FS, Lu E, Bowry S, et al. Myocardial ischemic memory imaging with molecular echocardiography. Circulation. 2007;115:345-352.
69. Constantinesco A, Choquet P, Monassier L, Israel-Jost V, Mertz L. Assessment of left ventricular perfusion, volumes, and motion in mice using pinhole gated SPECT. J Nucl Med. 2005;46:1005-1011.
70. Yang Y, Rendig S, Siegel S, Newport DF, Cherry SR. Cardiac PET imaging in mice with simultaneous cardiac and respiratory gating. Phys Med Biol. 2005;50:2979-2989.
71. Thomas D, Bal H, Arkles J, et al. Noninvasive assessment of myocardial viability in a small animal model: comparison of MRI, SPECT, and PET. Magn Reson Med. 2008;59:252-259.
72. Judenhofer MS, Catana C, Swann BK, et al. PET/MR images acquired with a compact MR-compatible PET detector in a 7-T magnet. Radiology. 2007;244:807-814.
73. Del Guerra A, Belcari N. State-of-the-art of PET, SPECT and CT for small animal imaging. Nucl Instrum Methods Phys Res A. 2007;583:119-124.
74. Davis S, Pogue B, Springett R, et al. Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue [abstract]. Rev Sci Instrum. 2008;79:064302.
75. Bengel FM, Schwaiger M. Assessment of cardiac sympathetic neuronal function using PET imaging. J Nucl Cardiol. 2004;11:603-616.
76. Carrio I. Cardiac neurotransmission imaging. J Nucl Med. 2001;42:1062-1076.
77. Merlet P, Valette H, Dubois-Rande JL, et al. Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure. J Nucl Med. 1992;33:471-477.
78. Agostini D, Verberne HJ, Burchert W, et al. I-123-MIBG myocardial imaging for assessment of risk for a major cardiac event in heart failure patients: insights from a retrospective European multicenter study. Eur J Nucl Med Mol Imaging. 2008;35:535-546.
79. Jacobson AF, Lombard J, Banerjee G, Camici PG. 123I-MIBG scintigraphy to predict risk for adverse cardiac outcomes in heart failure patients: design of two prospective multicenter international trials. J Nucl Cardiol. 2009;16:113-121.
80. Esler M, Jennings G, Lambert G, Meredith I, Horne M, Eisenhofer G. Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions. Physiol Rev. 1990;70:963-985.
81. Dae MW, Herre JM, O'Connell JW, Botvinick EH, Newman D, Munoz L. Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction. J Am Coll Cardiol. 1991;17:1416-1423.
82. McGhie AI, Corbett JR, Akers MS, et al. Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction. Am J Cardiol. 1991;67:236-242.
83. Matsunari I, Schricke U, Bengel FM, et al. Extent of cardiac sympathetic neuronal damage is determined by the area of ischemia in patients with acute coronary syndromes. Circulation. 2000;101:2579-2585.
84. Bulow HP, Stahl F, Lauer B, et al. Alterations of myocardial presynaptic sympathetic innervation in patients with multi-vessel coronary artery disease but without history of myocardial infarction. Nucl Med Commun. 2003;24:233-239.
85. Simoes MV, Barthel P, Matsunari I, et al. Presence of sympathetically denervated but viable myocardium and its electrophysiologic correlates after early revascularised, acute myocardial infarction. Eur Heart J. 2004;25:551-557.
86. Sasano T, Abraham MR, Chang KC, et al. Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia after myocardial infarction. J Am Coll Cardiol. 2008;51:2266-2275.
87. Kramer CM, Nicol PD, Rogers WJ, et al. Reduced sympathetic innervation underlies adjacent noninfarcted region dysfunction during left ventricular remodeling. J Am Coll Cardiol. 1997;30:1079-1085.
88. Sakata K, Mochizuki M, Yoshida H, et al. Cardiac sympathetic dysfunction contributes to left ventricular remodeling after acute myocardial infarction. Eur J Nucl Med. 2000;27:1641-1649.