Down-regulation of hypusine biosynthesis in plasmodium by inhibition of S-adenosyl-methionine-decarboxylase

Amino Acids

Volumn 38, Issue 2, 2010, Pages 461-469

  Blavid, Robert ^a   Kusch, Peter ^a   Hauber, Joachim ^b   Eschweiler, Ute ^a   Sarite, Salem Ramadan ^c   Specht, Sabine ^c   Deininger, Susanne ^c   Hoerauf, Achim ^c   Kaiser, Annette ^a,c  

^a BONN RHEIN SIEG UNIVERSITY OF APPLIED SCIENCES   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c Inst fur Med Mikrobiol/Immunol   (Germany)

Author keywords

AdoMETDC; EIF 5A; Malaria; SAM486A

Indexed keywords

4 AMIDINO 1 INDANONE 2' AMIDINOHYDRAZONE; ADENOSYLMETHIONINE DECARBOXYLASE; HYPUSINE; INITIATION FACTOR 5A; PUTRESCINE; SAM 486A; SPERMIDINE; SPERMINE; UNCLASSIFIED DRUG; 4-AMIDINOINDAN-1-ONE 2'-AMIDINOHYDRAZONE; AMIDINE; ENZYME INHIBITOR; INDAN DERIVATIVE; INITIATION FACTOR; PROTOZOAL PROTEIN; RNA BINDING PROTEIN;

AMINO ACID SYNTHESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; BRAIN MALARIA; CELL LEVEL; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING; ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KINETICS; MALARIA FALCIPARUM; METABOLISM; PARASITOLOGY;

EUKARYOTA; PLASMODIUM (APICOMPLEXA); PLASMODIUM FALCIPARUM;

ADENOSYLMETHIONINE DECARBOXYLASE; AMIDINES; ANIMALS; DOWN-REGULATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INDANS; KINETICS; MALARIA, FALCIPARUM; MICE; MICE, INBRED C57BL; PEPTIDE INITIATION FACTORS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; PUTRESCINE; RNA-BINDING PROTEINS; SPERMIDINE; SPERMINE;

EID: 77953047836     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-009-0405-x     Document Type: Conference Paper

References (28)

1. Andrus L, Szabo P, Grady RW, Hanauske AR, Huima-Byron T, Slowinska B, Zagulska S, Hanauske-Abel HM (1998) Antiretroviral effects of deoxyhypusyl hydroxylase inhibitors: a hypusine-dependent host cell mechanism for relication of human immunodeficiency virus type 1 (HIV-1). Biochem Pharmacol 55:1807-1818
2. Brun R, Buhler Y, Sandmeier U, Kaminsky R, Bacchi CJ, Rattendi D, Lane S, Croft SL, Snowdon D, Yardley V, Caravatti G, Frei J, Stanek J, Mett J (1996) In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors. Antimicrob Agents Chemother 40:1442-1447
3. Das Gupta R, Krause-Ihle T, Bergmann B, Müller IB, Khomutov AR, Müller S, Walter RD, Lüersen K (2005) 3-Aminooxy-1-aminopropane and derivatives have an antiproliferative effect on cultured Plasmodium falciparum by decreasing intracellular polyamine concentrations. Antimicrob Agents Chemother 49:2857-2864
4. Gregio AP, Cano VP, Avaca JS, Valentini SR, Zanelli CF (2009) EIF5A has a function in the elongation step of translation in yeast. Biochem Biophys Res Commun 380:785-790
5. Haider N, Eschbach ML, Dias Sde S, Gilberger TW, Walter RD, Lüersen K (2005) The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical analysis of the polyamine synthesis enzyme. Mol Biochem Parasitol 142:224-236
6. Hart RA, Billaud JN, Choi SJ, Phillips TR (2002) Effects of 1, 8-diaminooctane on the FIV Rev regulatory system. Virology 304:97-104
7. Hauber I, Bevec D, Heukeshoven J, Krätzer F, Horn F, Choidas A, Harrer T, Hauber J (2005) Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy. J Clin Investig 115:76-85
8. Kaiser A, Gottwald A, Wiersch C, Lindenthal B, Maier W, Seitz HM (2001) Effect of drugs inhibiting spermidine biosynthesis and metabolism on the in vitro development of Plasmodium falciparum. Parasitol Res 87:963-972
9. Kaiser A, Gottwald A, Maier W, Seitz HM (2003) Targeting enzymes involved in spermidine metabolism of parasitic protozoa-a possible new strategy for antiparasitic treatment. Parasitol Res 91:508-516
10. Klier H, Csonga R, Joäo HC, Eckerskorn C, Auer M, Lottspeich F, Eder J (1995) Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from Hela cells. Biochem 34:14693-14702
11. Liao DI, Wolff EC, Park MH, Davies DR (1998) Crystal structure of the NAD complex of the human deoxyhypusine synthase: an enzyme with a ball and chain mechanism for blocking the active site. Structure 6:23-32
12. Müller SA, Da'dara K, Lüersen C, Wrenger R, Das Gupta R, Madhubala R, Walter RD (2000) In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, S-adenosylmethionine decarboxylase. J Biol Chem 275:8097-8102
13. Müller S, Coombs GH, Walter RD (2001) Targeting polyamines of parasitic protozoa in chemotherapy. Trends Parasitol 17:242-249
14. Nishimura K, Murozumi K, Shirahata A, Park MH, Kashiwagi K, Igarashi K (2005) Independent roles of eIF5A and polyamines in cell proliferation. Biochem J 385:779-785
15. Park MH (2006) The post-translational synthesis of a polyaminederived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A). J Biochem 139:161-169
16. Park JH, Aravind L, Wolff EC, Kaevel J, Kim YS, Park MH (2006) Molecular cloning, expression and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. Proc Natl Acad Sci USA 103:51-56
17. Pless M, Belhadj K, Menssen HD, Kern W, Coiffier B, Wolf J, Herrmann R, Thiel E, Bootle D, Sklenar I, Muller C, Choi L, Porter C, Capdeville R (2004) Clinical efficacy, tolerability, and safety of SAM486A, a novel polyamine biosynthesis inhibitor, in patients with relapsed or refractory non-Hodgkin's lymphoma: results from a phase II multicenter study. Clin Cancer Res 10:1299-1305
18. Ramya T N C, Surolia N, Surolia A (2006) Polyamine synthesis and salvage pathways in the malaria parasite Plasmodium falciparum. Biochem Biophys Res Commun 348:579-584
19. Redmond JW, Tseng A (1978) High-pressure liquid chromatographic determination of putrescine, cadaverine, spermidine and spermine. J Chomatogr 170:479-481
20. Regenass U, Caravatti G, Mett H, Stanek J, Schneider P, Müller M, Matter A, Vertino P, Porter CW (1992) New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity. Cancer Res 52:4712-4718
21. Regenass U, Mett H, Stanek J, Mueller M, Kramer D, Porter CW (1994) CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res 54:3210-3217
22. Schäfer B, Hauber I, Bunk A, Heukeshoven J, Düsedau A, Bevec D, Hauber J (2006) Inhibition of multidrug-resistant HIV-1 by interference with cellular S-adenosylmethionine decarboxylase activity. J Infect Dis 15:740-750
23. Seiler N (2003) Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 1. Selective enzyme inhibitors. Curr Drug Targets 4:537-564
24. Specht S, Sarite SR, Hauber I, Hauber J, Görbig UF, Meier C, Bevec D, Hoerauf A, Kaiser A (2008) The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase. Parasitol Res 102:1177-1184
25. Wessel D, Flügge UI (1983) A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal Biochem 138:141-143
26. Wolff EC, Kang KR, Kim YS, Park MH (2007) Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification. Amino Acids 33:341-350
27. Wright PS, Byers TL, Cross-Doersen DE, McCann PP, Bitonti AJ (1991) Irreversible inhibition of S-adenosylmethionine decarboxylase in Plasmodium falciparum-infected erythrocytes: growth inhibition in vitro. Biochem Pharmacol 41:1713-1718
28. Zanelli CF, Valentini SR (2007) Is there a role for eIF5A in translation? Amino Acids 33:351-358