The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide

Cancer Chemotherapy and Pharmacology

Volumn 66, Issue 2, 2010, Pages 325-331

  Sookraj, Kelley A ^a   Bowne, Wilbur B ^a   Adler, Victor ^a   Sarafraz Yazdi, Ehsan ^a,c   Michl, Josef ^a,b,c   Pincus, Matthew R ^a,b  

^a Downstate Health Sciences University   (United States)

^b Department of Pathology and Laboratory Medicine ^*  (United States)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Anti cancer peptide; Confocal microscopy; Double fluorescent labeled peptide; Intramembrane target; PNC 27; Pore formation; Tumor cell necrosis

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; GREEN FLUORESCENT PROTEIN; PNC 27; RED FLUORESCENT PROTEIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN; 5 CARBOXYTETRAMETHYLRHODAMINE SUCCINIMIDYL ESTER; 5-CARBOXYTETRAMETHYLRHODAMINE SUCCINIMIDYL ESTER; COLORING AGENT; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; LACTATE DEHYDROGENASE; PNC-27; PROTEIN P53; RHODAMINE; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL KILLING; CELL MEMBRANE; CELL STRAIN MCF 7; CELL TRANSFORMATION; CELL VIABILITY; CHANNEL GATING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOLYSIS; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL; TUMOR NECROSIS; DRUG EFFECT; METABOLISM; NECROSIS; NEOPLASM; PATHOLOGY; TUMOR CELL LINE; ULTRASTRUCTURE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL MEMBRANE; COLORING AGENTS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; GREEN FLUORESCENT PROTEINS; HUMANS; L-LACTATE DEHYDROGENASE; MICROSCOPY, CONFOCAL; NECROSIS; NEOPLASMS; RHODAMINES; TETRAZOLIUM SALTS; THIAZOLES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77953041785     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1166-7     Document Type: Article

References (8)

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