Naloxone reversal of morphine- and morphine-6-glucuronide-induced respiratory depression in healthy volunteers: A mechanism-based pharmacokinetic-pharmacodynamic modeling study

Anesthesiology

Volumn 112, Issue 6, 2010, Pages 1417-1427

  Olofsen, Erik ^a   Van Dorp, Eveline ^a   Teppema, Luc ^a   Aarts, Leon ^a   Smith, Terry W ^a   Dahan, Albert ^a   Sarton, Elise ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; MORPHINE; MORPHINE 6 GLUCURONIDE; NALOXONE; PLACEBO; SODIUM CHLORIDE;

ADULT; ARTICLE; BREATHING RATE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG HALF LIFE; END TIDAL CARBON DIOXIDE TENSION; FEMALE; HUMAN; HUMAN EXPERIMENT; LUNG MINUTE VOLUME; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RESPIRATION DEPRESSION; SINGLE BLIND PROCEDURE; TREATMENT DURATION; TREATMENT OUTCOME; VOLUNTEER;

EID: 77953021512     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181d5e29d     Document Type: Article

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