Influences of morphine on the ventilatory response to isocapnic hypoxia

Anesthesiology

Volumn 86, Issue 6, 1997, Pages 1342-1349

  Berkenbosch, Aad ^a   Teppema, Luc J ^a   Olievier, Cees N ^a   Dahan, Albert ^a  

^a Department of Physiology ^*

Author keywords

Analgesics, opioid: morphine; Anesthesia: chloralose urethan; Measurement techniques: carbon dioxide ventilatory response; dynamic end tidal forcing; hypoxic ventilatory response; Receptors, chemoreceptors: central; peripheral; Species: cat; Ventilation, lung: hypoxia; hyperoxia; hypercapoia

Indexed keywords

MORPHINE;

ANIMAL EXPERIMENT; ARTICLE; CAT; DRUG EFFECT; END TIDAL CARBON DIOXIDE TENSION; FEMALE; HYPEROXIA; HYPOXIA; LUNG VENTILATION; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL;

ANALGESICS, OPIOID; ANIMALS; ANOXIA; CARBON DIOXIDE; CATS; FEMALE; MORPHINE; OXYGEN; PARTIAL PRESSURE; PULMONARY VENTILATION; TIDAL VOLUME;

EID: 0030898305     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199706000-00016     Document Type: Article

References (26)

1. Berkenbosch A, Olievier CN, Wolsink JG, deGoede J, Rupreht J: Effect of morphine and physostigmine on the ventilatory response to carbon dioxide. ANESTHESIOLOGY 1994; 80:1303-10
2. Bourke DL, Warley A: The steady-state and rebreathing methods compared during morphine administration in humans. J Physiol Lond 1989; 419:509-17
3. Weil JV, McCullough RE, Kline JS, Sodal I: Diminished ventilatory response to hypoxia and hypercapnia after morphine in normal men. N Engl J Med 1975; 292:1103-6
4. Gross JB, Blouin RT, Zandsberg S, Conard PF, Häusler J: Effect of flumazenil on ventilatory drive during sedation with midazolam and alfentanyl. ANESTHESIOLOGY 1996; 85:713-20
5. Santiago TV, Johnson J, Riley DJ, Edelman NH: Effects of morphine on ventilatory response to exercise. J Appl Physiol 1979; 47:112-8
6. Vizek M, Pickett CK, Weil JV: Biphasic ventilatory response of adult cats has central origin. J Appl Physiol 1987; 93:1658-64
7. van Beek JHGM, Berkenbosch A, DeGoede J, Olievier CN: Effects of brainstem hypoxaemia on the regulation of breathing. Respir Physiol 1984; 57:171-88
8. Berkenbosch A, Olievier CN, DeGoede J: Respiratory responses to hypoxia: peripheral and central effects. Modelling and Control of Ventilation. Advances in Experimental Medicine and Biology, Vol. 393. Edited by Semple SJG, Adams L, Whipp BJ. New York, Plenum Press, 1995, pp. 251-6
9. 2 and hypoxia after sustained hypoxia in awake cats." J Appl Physiol 1994; 76:2251-2
10. Gautier H, Bonora M: Effects of carotid denervation on respiratory pattern of awake cats. J Appl Physiol 1979; 46:1127-31
11. van Dissel JT, Berkenbosch A, Olievier CN, DeGoede J, Quanjer PH: Effects of halothane on the ventilatory response to hypoxia and hypercapnia in cats. ANESTHESIOLOGY 1985; 62:-448-56
12. DeGoede J, Berkenbosch A, Ward DS, Bellville JW, Olievier CN: Comparison of chemoreflex gains obtained with two different methods in cats. J Appl Physiol 1985; 59:170-9
13. ε -nitro-L-argtnine on ventilatory response to hypercapnia in anesthetized cats. J Appl Physiol 1997; 82:292-7
14. 2. J Appl Physiol 1991; 71:1123-8
15. 2 in anaesthetized cats during hyperoxia. Respir Physiol 1979; 37:381-90
16. DeGoede J, Berkenbosch A, Olievier CN, Quanjer PH: Ventilatory response to carbon dioxide and apneic thresholds. Respir Physiol 1981; 45:185-99
17. Easton PA, Slykerman LJ, Anthonisen NR: Ventilatory response to sustained hypoxia in normal adults. J Appl Physiol 1986; 61:906-11
18. Ward DS, Berkenbosch A, DeGoede J, Olievier CN: Dynamics of the ventilatory response to central hypoxia in cats. J Appl Physiol 1990; 68:1107-13
19. Berkenbosch A, Olievier CN, DeGoede J, Kruyt EW: Effect on ventilation of papaverine administered to the brain stem of the anesthetized cat. J Physiol [London] 1991; 443:457-68
20. Santiago TV, Edelman NH: Brain blood flow and control of breathing, Handbook of Physiology: section 3. The Respiratory System, vol. 2: Control of Breathing. Edited by Cherniack NS, Widdicombe JG. Bethesda, American Physiological Society, 1986, pp. 163-79
21. Weyne J, VanLeuven F, Leusen I: Brain amino acids in conscious rats in chronic normocapnic and hypocapnic hypoxemia. Respir Physiol 1977; 31:231-9
22. 2 concentration on short tenn potentiation of breathing in humans. J Physiol (London) 1995; 488:803-15
23. 2 and hypoxia after sustained hypoxia in awake cats. J Appl Physiol 1994; 76:2262-6
24. Dahan A: General anesthesia and control of respiration. Seminars in Anesthesia 1996; 15:328-34
25. Bailey PL, Pace NL, Ashburn MA, Moll JWB, East KA, Stanley TH: Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. ANESTHESIOLOGY 1990; 73:826-30
26. Lam AM, Clement JL, Knill RL: Surgical stimulation does not enhance ventilatory chemoreflexes during enflurane anesthesia in man. Can Anaesth Soc J 1980; 27:22-8