Prenatal MDMA exposure delays postnatal development in the rat: A preliminary study

Neurotoxicology and Teratology

Volumn 32, Issue 4, 2010, Pages 425-431

  Heuland, Emilie ^a   Germaux, Marie Aure ^a   Galineau, Laurent ^a   Chalon, Sylvie ^a   Belzung, Catherine ^a  

^a INSERM   (France)

Author keywords

3,4 methylenedioxymethamphetamine; Neurobehavioral development; Prenatal exposure; Reflex

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; FEMALE; LACTATION; LONG TERM EXPOSURE; MALE; MATERNAL BEHAVIOR; MOTOR COORDINATION; NERVE CELL NETWORK; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; PHYSICAL DEVELOPMENT; POSTNATAL DEVELOPMENT; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; RIGHTING REFLEX;

ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; FEMALE; GAIT; MALE; MATERNAL BEHAVIOR; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; REFLEX;

ANIMALIA; RATTUS;

EID: 77953020690     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2010.03.006     Document Type: Article

References (65)

1. Altman J., Sudarshan K. Postnatal development of locomotion in the laboratory rat. Anim. Behav. 1975, 23:896-920.
2. Banken J.A. Drug abuse trends among youth in the United States. Ann. N. Y. Acad. Sci. 2002, 1025:465-471.
3. Bayer S.A., Altman J., Russo R.J., Zhang X. Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 1993, 14:83-144.
4. Bennett-Clarke C.A., Leslie M.J., Lane R.D., Rhoades R.W. Effect of serotonin depletion on vibrissae-related patterns of thalamic afferents in the rat's somatosensory cortex. J. Neurosci. 1994, 14:7594-7607.
5. Borella A., Bindra M., Whitaker-Azmitia P.M. Role of the 5-HT1A receptor in development of the neonatal rat brain: preliminary behavioral studies. Neuropharmacology 1997, 36:445-450.
6. Brezun J.M., Daszuta A. Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats. Neuroscience 1999, 89:999-1002.
7. Campbell N.G., Koprich J.B., Kanaan N.M., Lipton J.W. MDMA administration to pregnant Sprague-Dawley rats results in its passage to the fetal compartment. Neurotoxicol. Teratol. 2006, 28:459-465.
8. Cases O., Vitalis T., Seit I., De Maeyer E., Sotelo C., Gaspar P. Lack of Barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period. Neuron 1996, 16:297-307.
9. Chevalet P., Le Pape G., Lassale J.M. Développement comportemental avant le sevrage chez la souris: méthodes et technique de mesure et d'analyse. Sci. Tech. Anim. Lab. 1998, 13:157-168.
10. Colado M.I., O'Shea E., Granados R., Misra A., Murray T.K., Green A.R. A study of neurotoxic effect of MDMA ('ecstasy') on 5-HT neurones in the brains of mothers and neonates following administration of the drug during pregnancy. Br. J. Pharmacol. 1997, 121:827-833.
11. Cole J.C., Bailey M., Sumnall H.R., Wagstaff G.F., King L.A. The content of ecstasy tablets: implications for the study of their long-term effects. Addiction 2002, 97:1531-1536.
12. Commins D.L., Vosmer G., Virus R.M., Woolverton W.L., Schuster C.R., Seiden L.S. Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain. J. Pharmacol. Exp. Ther. 1987, 241:338-345.
13. Costa L.G., Aschner M., Vitalone A., Syversen T., Soldin O.P. Developmental neuropathology of environmental agents. Annu. Rev. Pharmacol. Toxicol. 2004, 44:87-110.
14. Cransac H., Cottet-Emard J.M., Pequignot J.M., Peyrin L. Monoamines (norepinephrine, dopamine, serotonin) in the rat medial vestibular nucleus: endogenous levels and turnover. J. Neural. Transm. 1996, 103:391-401.
15. Derrick M., Luo N.L., Bregman J.C., Jilling T., Ji X., Fisher K., Gladson C.L., Beardsley D.J., Murdoch G., Back S.A., Tan S. Preterm fetal hypoxia-ischemia causes hypertonia and motor deficits in the neonatal rabbit: a model for human cerebral palsy?. J. Neurosci. 2004, 24:24-34.
16. de Souza S.L., Nogueira M.I., de Jesus Deiró T.C., de Castro F.M., da Silva C.M., da Silva M.C., de Lira L.O., Azmitia E.C., de Castro R.M. Differential effects on somatic and reflex development by chronic clomipramine treatment. Physiol. Behav. 2004, 82:375-379.
17. Dobbing J., Sands J. Quantitative growth and development of human brain. Arch. Dis. Child. 1973, 48:757-767.
18. Draper E.S., Rankin J., Tonks A.M., Abrams K.R., Field D.J., Clarke M., Kurinczuk J.J. Recreational drug use: a major risk factor for gastroschisis?. Am. J. Epidemiol. 2008, 167:485-491.
19. Edwards M.J., Shiota K., Smith M.S.R., Walsh D.A. Hyperthermia and birth defects. Reprod. Toxicol. Rev. 1995, 9:411-425.
20. Fitzgerald J.L., Reid J.J. Sympathomimetic actions of methylenedioxymethamphetamine in rat and rabbit isolated cardiovascular tissues. J. Pharmacol. 1994, 46:826-832.
21. Fleming A.S., Walsh C. Neuropsychology of maternal behavior in the rat: c-fos expression during mother-litter interactions. Psychoneuroendocrinol. 1994, 19:429-443.
22. Fox W.M. Reflex ontogeny and behavioural development of the mouse. Anim. Behav. 1965, 13:234-241.
23. Galineau L., Belzung C., Kodas E., Bodard S., Guilloteau D., Chalon S. Prenatal 3,4-methylenedioxymethanphetamine (ecstasy) exposure induces long-term alterations in dopaminergic and serotonergic functions in the rat. Brain Res., Dev. Brain Res. 2005, 154:165-176.
24. Gil-Loyzaga P., Vicente-Torres M.A., García-Bonacho M., Esquifino A. Presence of catecholamines and serotonin in the rat vestibule. Br. Res. 1997, 746:265-268.
25. Gouzoulis-Mayfrank E., Daumann J. The confounding problem of polydrug in recreational ecstasy/MDMA users: a brief overview. J. Psychopharmacol. 2006, 20:188-193.
26. Green A.R., O'Shea E., Saadat K.S., Elliott J.M., Colado M.I. Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures. Br. J. Pharmacol. 2005, 146:306-312.
27. Green A.R., Sanchez V., O'Shea E., Saadat K.S., Elliott J.M., Colado M.I. Effect of ambient temperature and a prior neurotoxic dose of 3, 4-methylenedioxymethamphetamine (MDMA) on the hyperthermic response of rats to a single or repeated ('binge' ingestion) low dose of MDMA. Psychopharmacology (Berl) 2004, 173:264-269.
28. Gudelsky G.A., Yamamoto B.K. Actions of 3, 4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons. Pharmacol. Biochem. Behav. 2008, 90:198-207.
29. Gurtman C.G., Morley K.C., Li K.M., Hunt G.E., McGregor I.S. Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion. Eur. J. Pharmacol. 2002, 446:89-96.
30. Herlenius E., Lagercrantz H. Development of neurotransmitter systems during critical periods. Exp. Neurol. 2004, 190:8-21.
31. Ho E., Karimi-Tebesh L., Koren G. Characteristics of pregnant women who use ecstasy (3, 4-methylenedioxymethamphetamine). Neurotoxicol. Teratol. 2001, 23:561-567.
32. Holson R.R., Freshwater L., Maurissen J.P.J., Moser V.C., Phang W. Statistical issues and techniques appropriate for developmental neurotoxicity testing, A report from ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol. Teratol. 2008, 30:326-348.
33. Johns J.M., Noonan L.R., Zimmerman L.I., Li L., Pedersen C.A. Effects of chronic and acute cocaine treatment on the onset of maternal behavior and aggression in Sprague-Dawley rats. Behav. Neurosci. 1994, 108:107-112.
34. Johnston L.D., O'Malley P.M., Bachman J.G., Sculenberg J.E. Monitoring the future: national results on adolescent drug abuse: overview of key findings, 2006. NIH Publication Number 07-6202 2007, National Institute on drug abuse, Bethesdia, MD.
35. Kobeissy F.H., Jeung J.A., Warren M.W., Geier J.E., Gold M.S. Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats. Addict. Biol. 2008, 13:15-25.
36. Koprich J.B., Chen E.Y., Kanaan N.M., Campbell N.G., Kordower J.H., Lipton J.W. Prenatal 3, 4-methylenedioxymethanphetamine (ecstasy) alters exploratory behaviour, reduces monoamine metabolism, and increases forebrain tyrosine hydroxylase fiber density of juvenile rats. Neurotoxicol. Teratol. 2003, 25:509-517.
37. Levallois C., Valence C., Baldet P., Privat A. Morphological and morphometric analysis of serotonin-containing neurons in primary dissociated cultures of human rhombencephalon: a study of development. Brain Res., Dev. Brain Res. 1997, 99:243-252.
38. Levitt P., Harvey J.A., Friedman E., Simansky K., Murphy E.H. New evidence for neurotransmitter influences on brain development. Trends Neurosci. 1997, 20:269-274.
39. Lin J.H. Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics. Drug Metab. Dispo. 1998, 26:1202-1212.
40. Lubics A., Reglodi D., Tamas A., Kiss P., Szalai M., Szalontay L., Lengvari I. Neurological reflexes and early motor behaviour in rats subjected to neonatal hypoxic-ischemic injury. Behav. Br. Res. 2005, 157:157-165.
41. Lyles J., Cadet J.L. Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms. Brain Res., Brain Res. Rev. 2003, 42:155-168.
42. Malberg J.E., Seiden L.S. Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat. J. Neurosci. 1998, 18:5086-5094.
43. McElhatton P.R., Baterman D.N., Evans C., Pughe K.R., Thomas S.H. Congenital anomalies after prenatal ecstasy exposure. Lancet 1999, 354:1141-1142.
44. Molliver D.C., Molliver M.E. Anatomic evidence for a neurotoxic effect of (+/-)-fenfluramine upon serotonergic projections in the rat. Br. Res. 1990, 511:165-168.
45. Motz B.A., Alberts J.R. The validity and utility of geotaxis in young rodents. Neuroteratol. Toxicol. 2005, 27:529-533.
46. O'Hearn E., Battaglia G., De Souza E.B., Kuhar M.J., Molliver M.E. Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. J. Neurosci. 1988, 8:2788-2803.
47. O'Shea E., Orio L., Escobedo I., Sanchez V., Camarero J., Green A.R., Colado M.I. MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperature. Br. J. Pharmacol. 2006, 148:778-785.
48. Parrott A.C. Recreational ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity. Pharmacol. Biochem. Behav. 2002, 71:837-844.
49. Patin V., Vincent A., Lordi B., Caston J. Does prenatal stress affect the motoric development of rat pups?. Brain Res., Dev. Brain Res. 2004, 149:85-92.
50. Ricceri L., Moles A., Crawley J. Behavioral phenotyping of mouse models of neurodevelopmental disorders: relevant social behavior patterns across the life span. Behav. Br. Res. 2007, 176:40-52.
51. Ronca A.E., Alberts J.R. Effects of prenatal spaceflight on vestibular responses in neonatal rats. J. Appl. Physiol. 2000, 89:2318-2324.
52. Schmidt C.J., Wu L., Lovenberg W. Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue. Eur. J. Pharmacol. 1986, 124:175-178.
53. Slamberova R., Charousova P., Pometlova M. Maternal behavior is impaired by methamphetamine administered during pre-mating, gestation and lactation. Reprod. Toxicol. 2005, 20:103-110.
54. Sundström E., Kölare S., Souverbie F., Samuelsson E.B., Pschera H., Lunell N.O., Seiger A. Neurochemical differentiation of human bulbospinal monoaminergic neurons during the first trimester. Brain Res., Dev. Brain Res. 1995, 75:1-12.
55. St Omer V.E., Ali S.F., Holson R.R., Duhart H.M., Scalzo F.M., Jr W. Slikker, Behavioral and neurochemical effects of prenatal methylenedioxymethamphetamine (MDMA) exposure in rats. Neurotoxicol. Teratol. 1991, 13:13-20.
56. Tanner-Smith E.E. Pharmacological content of tablets sold as "ecstasy": results from an online testing service. Drug Alcohol Depend. 2006, 83:247-254.
57. Thompson V.B., Heimer J., Chambers J.B., Benoit S.C., Buering W.R., Norman M.K., Norman A.B., Lipton J.W. Long-term behavioural consequences of prenatal MDMA exposure. Physiol. Behav. 2009, 96:593-601.
58. Uriarte N., Breigeiron M.K., Benetti F., Rosa X.F., Lucion A.B. Effects of maternal care on the development, emotionality, and reproductive functions in male and female rats. Dev. Psychobiol. 2007, 49:451-462.
59. Vaccarino F.M., Ment L.R. Injury and repair in developing brain. Arch. Dis. Child Fetal Neonatal. Eds. 2004, 89:190-192.
60. Verrico C.D., Miller G.M., Madras B.K. MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology 2007, 189:489-503.
61. Vinay L., Ben-Mabrouk F., Brocard F., Clarac F., Jean-Xavier C., Pearlstein E., Pflieger J.F. Perinatal development of the motor systems involved in postural control. Neural. Plast. 2005, 12:131-139.
62. Whitaker-Azmitia P.M. Serotonin and brain development: role in human developmental diseases. Br. Res. Bull. 2001, 56:479-485.
63. Williams M.T., Brown C.A., Skelton M.R., Vinks A.A., Vorhees C.V. Absorption and clearance of ±3, 4-methylenedioxymethanphetamine from the plasma of neonatal rats. Neurotoxicol. Teratol. 2004, 26:849-856.
64. Won L., Bubula N., Heller A. Fetal exposure to (±)methylenedioxymethanphetamine in utero enhances the development and metabolism of serotonergic neurons in three-dimensional reaggregate tissue culture. Brain Res., Dev. Brain Res. 2002, 137:67-73.
65. Zhou F.C., Sari Y., Zhang J.K. Expression of serotonin transporter protein in developing rat brain. Brain Res., Dev. Brain Res. 2000, 119:33-45.