Interaction of epicutaneously applied lipids with stratum corneum depends on the presence of either emulsifiers or hydrogenated phosphatidylcholine

Skin Pharmacology and Physiology

Volumn 23, Issue 6, 2010, Pages 298-305

  Wohlrab, J ^a   Klapperstuck T ^a   Reinhardt, H W ^b   Albrecht, M ^c  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b Stiefel Laboratorium GmbH   (Germany)

^c Kuhs GmbH   (Germany)

Author keywords

Barrier function; Emulsifier; Phosphatidylcholine; Stratum corneum

Indexed keywords

EMULSIFYING AGENT; FATTY ACID; LIPID; PHOSPHATIDYLCHOLINE;

ARTICLE; BREAST REDUCTION; CONTROLLED STUDY; EX VIVO STUDY; EXCISION; HUMAN; HUMAN TISSUE; HYDROGENATION; HYDROPHILICITY; LIPID MEMBRANE; LIPOPHILICITY; PRIORITY JOURNAL; SKIN; STRATUM CORNEUM; TRANSITION TEMPERATURE;

EID: 77953016542     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000313515     Document Type: Article

References (22)

1. Schmidt-Wendtner MH, Korting HC: The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol 2006; 19: 296-302.
2. Bouwstra JA, Dubbelaar FE, Gooris GS, Weerheim AM, Ponec M: The role of ce-ramide composition in the lipid organisation of the skin barrier. Biochim Biophys Acta 1999; 1419:127-136.
3. Coderch L, Lopez O, de la MA, Parra JL: Ce-ramides and skin function. Am J Clin Dermatol 2003; 4:107-129.
4. Kessner D, Ruettinger A, Kiselev MA, Warte wig S, Neubert RH: Properties of ce-ramides and their impact on the stratum corneum structure. 2. Stratum corneum lip-id model systems. Skin Pharmacol Physiol 2008; 21: 58-74.
5. Mao-Qiang M, Elias PM, Feingold KR: Fatty acids are required for epidermal permeability barrier function. J Clin Invest 1993; 92: 791-798.
6. Elias PM: Epidermal lipids, membranes, and keratinization. Int J Dermatol 1981; 20:1-19.
7. Elias PM: Epidermal lipids, barrier function, and desquamation. J Invest Dermatol 1983; 80(suppl):44s-49s.
8. Smith WP, Christensen MS, Nacht S, Gans EH: Effect of lipids on the aggregation and permeability of human stratum corneum. J Invest Dermatol 1982; 78:7-11.
9. Barai ND, Supp AP, Kasting GB, Visscher MO, Boyce ST: Improvement of epidermal barrier properties in cultured skin substitutes after grafting onto athymic mice. Skin Pharmacol Physiol 2007; 20:21-28.
10. Farwanah H, Raith K, Neubert RH, Wohlrab J: Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin. Arch Dermatol Res 2005; 296: 514-521.
11. Armen RS, Uitto OD, Feller SE: Phospholip-id component volumes: determination and application to bilayer structure calculations. Biophys J 1998; 75: 734-744.
12. Bringezu F, Dobner B, Brezesinski G: Generic phase behavior of branched-chain phos-pholipid monolayers. Chemistry 2002; 8: 3203-3210.
13. Xhauflaire-Uhoda E, Vroome V, Cauwen-bergh G, Pierard GE: Dynamics of skin barrier repair following topical applications of miconazole nitrate. Skin Pharmacol Physiol 2006; 19: 290-294.
14. Menon GK, Brandsma JL, Schwartz PM: Particle-mediated gene delivery and human skin: ultrastructural observations on stratum corneum barrier structures. Skin Pharmacol Physiol 2007; 20:141-147.
15. Verma DD, Verma S, Blume G, Fahr A: Particle size of liposomes influences dermal delivery of substances into skin. Int J Pharm 2003; 258:141-151.
16. Sheu HM, Chao SC, Wong TW, Yu-Yun LJ, Tsai JC: Human skin surface lipid film: an ultrastructural study and interaction with corneocytes and intercellular lipid lamellae of the stratum corneum. Br J Dermatol 1999; 140:385-391.
17. Kirjavainen M, Urtti A, Jaaskelainen I, Suhonen TM, Paronen P, Valjakka-Koskela R, Kiesvaara J, Monkkonen J: Interaction of liposomes with human skin in vitro-the influence of lipid composition and structure. Biochim Biophys Acta 1996; 1304: 17 9-18 9.
18. Contreras TJ, Hunt SM, Lionetti FJ, Valeri CR: Preservation of human granulocytes. III. Liquid preservation studied by electronic sizing. Transfusion 1978; 1 8: 46-53.
19. Kemeny L, Koreck A, Kis K, Kenderessy-Sza-bo A, Bodai L, Cimpean A, Paunescu V, Rai-ca M, Ghyczy M: Endogenous phospholipid metabolite containing topical product inhibits ultraviolet light-induced inflammation and DNA damage in human skin. Skin Pharmacol Physiol 2007; 20:155-161.
20. Yilmaz E, Borchert HH: Effect of lipid-con-taining, positively charged nanoemulsions on skin hydration, elasticity and erythema-an in v ivo study. Int J Pharm 2006; 307: 232-238.
21. Eberlein B, Eicke C, Reinhardt HW, Ring J: Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmi-toylethanolamine (ATOPA study). J Eur Acad Dermatol Venereol 2008; 22:73-82.
22. Wohlrab J, Donald A, Albrecht M: Influence of hydrogenated phosphatidylcholine cream vs. emulsifier cream on structure of the lipid barrier of the stratum corneum. J Am Acad Dermatol 2005; 52 (suppl):135.