Dynamics of skin barrier repair following topical applications of miconazole nitrate

Skin Pharmacology and Physiology

Volumn 19, Issue 5, 2006, Pages 290-294

  Xhauflaire Uhoda, E ^a   Vroome, V ^b   Cauwenbergh, G ^c   Pierard G E ^a,d  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b Barrier Therapeutics   (Belgium)

^c Barrier Therapeutics   (United States)

^d CHU SART TILMAN   (Belgium)

Author keywords

Miconazole nitrate; Skin barrier function; Stratum corneum; Surfactant challenge; Transepidermal water loss

Indexed keywords

CYANOACRYLATE; MICONAZOLE; MICONAZOLE NITRATE; PETROLATUM; TISSUE ADHESIVE; ZINC OXIDE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; FOREARM; HUMAN; HUMAN TISSUE; NORMAL HUMAN; OUTCOME ASSESSMENT; PASTE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN FUNCTION; SKIN SURFACE; SKIN WATER LOSS; STRATUM CORNEUM; TISSUE REPAIR;

ADMINISTRATION, TOPICAL; ADULT; BODY WATER; DOUBLE-BLIND METHOD; HUMANS; MICONAZOLE; MIDDLE AGED; SKIN;

EID: 33748317917     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000093985     Document Type: Article

References (38)

1. Yardley HJ: Epidermal lipids. Int J Cosmet Sci 1987;9:13-19.
2. Elias PM, Menon GK, Grayson S, Brown BE: Membrane structural alterations in murine stratum corneum. Relationship to the localization of polar lipids and phospholipases. J Invest Dermatol 1988;91:3-10.
3. Rawlings AV, Davies A, Carlomusto M, Pillai S, Zhang K, Kosturko R, Verdejo P, Feinberg C, Nguyen L, Chandar P: Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Dermatol Res 1996;288:383-390.
4. Wertz PW: Stratum corneum lipids and water. Exog Dermatol 2004;3:53-56.
5. Tsuruta D, Green K, Gessios S, Jones J: The barrier function of skin: how to keep a tight lid on water loss. Trends Cell Biol 2002;12:355-357.
6. Smith W: Stratum corneum barrier integrity controls skin homeostasis. Int J Cosmet Sci 1999;21:107-118.
7. Rawlings AV: Dry skin: environmental aspects. Exog Dermatol 2004;3:57-71.
8. von den Driesch P, Fartasch M, Huner A, Ponec M: Expression of integrin receptors and ICAM-1 on keratinocytes in vivo and in an in vitro reconstructed epidermis: effect of sodium dodecyl sulphate. Arch Dermatol Res 1995;287:249-253.
9. Takagi Y, Kakagawa H, Higuchi K, Imokawa G: Characterization of surfactant-induced skin damage through barrier recovery induced by pseudoacylceramides. Dermatology 2005;211:128-131.
10. Zhai H, Poblete N, Maibach HI: Stripped skin model to predict irritation potential of topical agents in vivo in humans. Int J Dermatol 1998; 37:386-389.
11. Bashir SJ, Chew AL, Anigbogu A, Dreher F, Maibach HI: Physical and physiological effects of stratum corneum tape stripping. Skin Res Technol 2001;7:40-48.
12. Weigmann HJ, Ulrich J, Schanzer S, Jacobi U, Schaefer H, Sterry W, Lademann J: Comparison of transepidermal water loss and spectroscopic absorbance to quantify changes of the stratum corneum after tape stripping. Skin Pharmacol Physiol 2005;18:180-185.
13. Kalia YN, Alberti I, Sekkat N, Curdy C, Naik A, Guy R: Normalization of stratum corneum barrier function and transepidermal water loss in vivo. Pharm Res 2000;17:1148-1150.
14. Grubauer G, Elias PM, Feingold KR: Transepidermal water loss. The signal for recovery of barrier structure and function. J Lipid Res 1989;30:323-333.
15. Uhoda E, Piérard-Franchimont C, Wang X, Piérard GE: Repair kinetics of stratum corneum under repeated insults. Exog Dermatol 2004;3:7-11.
16. Okuda M, Yoshiike T, Ogawa H: Detergent-induced epidermal barrier dysfunction and its prevention. J Dermatol Sci 2002;30:173-179.
17. Pigatto PD, Biardi AS, Legori A, Altomare FG, Finzi AF: Are barrier creams of any use in contact dermatitis? Contact Dermatitis 1992;2226:197.
18. Goffin V, Piérard-Franchimont C, Piérard GE: Shielded corneosurfametry and corneoxenometry: novel bioassays for the assessment of skin barrier products. Dermatology 1998;196:434-437.
19. Fluhr JW, Gloor M, Lehmann L, Lazzerini S, Distante F, Berardesca E: Glycerol accelerates recovery of barrier function in vivo. Act Derm Venereol 1999;79:418-421.
20. Barany E, Lindberg M, Loden M: Unexpected skin barrier influence from non-ionic emulsifiers. Int J Pharm 2000;195:189-195.
21. Kucharekova M, Schalkwijk J, Van De Kerkhof PC, Van De Valk PG: Effect of a lipid-rich emollient. Contact Dermatitis 2002;46:331-338.
22. Denda M, Kumazawa N: Negative electric potential induces alteration of ion gradient and lamellar body secretion in the epidermis, and accelerates skin barrier recovery after barrier disruption. J Invest Dermatol 2002;118:65-72.
23. Denda M, Nakanishi K, Kumazawa N: Topical application of ionic polymers affects skin permeability barrier homeostasis. Skin Pharmacol Physiol 2005;18:36-41.
24. Takagi Y, Nakagawa H, Higuchi K, Imokawa G: Characterization of surfactant-induced skin damage through barrier recovery induced by pseudoacylceramides. Dermatology 2005;211: 128-134.
25. Piérard-Franchimont C, Letawe C, Piérard GE: Tribological and mycological consequences of the use of a miconazole nitrate-containing paste for the prevention of diaper dermatitis: an open pilot study. Eur J Ped 1996;155:756-758.
26. Concannon P, Gisoldi E, Phillips S, Grossman R: Diaper dermatitis: a therapeutic dilemma. Results of a double-blind placebo controlled trial of miconazole nitrate 0.25%. Pediatr Dermatol 2001;18:149-155.
27. Petit L, Piérard-Franchimont C, Uhoda E, Vroome V, Cauwenbergh G, Piérard GE: Coping with mild inflammatory catamenial acne. A clinical and bioinstrumental split-face assessment. Skin Res Technol 2004;10:278-282.
28. Flagothier C, Vroome V, Borgers M, Wang X, Cauwenbergh G, Piérard GE: Effect of a single overnight topical application of miconazole nitrate paste on acne papules. Int J Dermatol, in press.
29. Rogiers V: EEMCO guidance for the assessment of the transepidermal water loss (TEWL) in cosmetic sciences. Skin Pharmacol Appl Skin Physiol 2001;14:117-128.
30. Denda M, Tsuchiya T: Barrier recovery rate varies time-dependently in human skin. Br J Dermatol 2000;142:881-884.
31. Paye M, Gomes G, Zerweg Ch, Piérard GE, Grove GG: A hand immersion test under laboratory-controlled usage conditions: a need for sensitive and controlled assessment methods. Contact Dermatitis 1999;40:133-138.
32. Abrams K, Harvell JD, Shriner D, Wertz P, Maibach H, Maibach HI, Rehfeld SJ: Effect of organic solvents on in vitro human skin water barrier function. J Invest Dermatol 1993;101:609-613.
33. Goffin V, Piérard-Franchimont C, Piérard GE: Passive sustainable hydration of the stratum corneum following surfactant challenge. Clin Exp Dermatol 1999;24:308-311.
34. Van Cromphaut I, Fumal I, Jacquemin D, Fissette J, Piérard GE: Skin barrier repair after contact burns. Electrometric evaluation using the passive sustainable hydration test. J Environ Med 1999;1:47-50.
35. Uhoda E, Lévêque JL, Piérard GE: Silicon image sensor technology for in vivo detection of surfactant induced corneocyte swelling and drying. Dermatology 2005;250:184-188.
36. Xhauflaire-Uhoda E, Piérard GE: Skin capacitance imaging of acne lesions. Skin Res Technol, in press.
37. Xhauflaire-Uhoda E, Haubrechts C, Loussouarn G, Lévêque JL, Saint Léger D, Piérard GE: Skin capacitance imaging and corneosurfametry. A comparative assessment of the impact of surfactants on stratum corneum. Contact Dermatitis, in press.
38. Imokawa G: Surfactant-induced depletion of ceramides and other intercellular lipids: implication for the mechanism leading to dehydration of the stratum corneum. Exog Dermatol 2004;3:81-98.