Novel 2-hydrazino-pyrimidin-4(3H)-one derivatives as potential dihydrofolate reductase inhibitors

Journal of Heterocyclic Chemistry

Volumn 47, Issue 3, 2010, Pages 558-563

  Degani, Mariam S ^a   Bag, Seema ^a   Bairwa, Ranjeet ^a   Tawari, Nilesh R ^a   Queenerb, Sherry F ^b  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 (1,3 DIPHENYLPROPYLIDENE)HYDRAZINYL) 6 METHYL 5 PROPYLPYRIMIDIN 4(3H) ONE; 2 (2 (1,3 DIPHENYLPROPYLIDENE)HYDRAZINYL) 6 METHYLPYRIMIDIN 4(3H) ONE; 2 [2 [1 (5 BROMOTHIOPHEN 2 YL)ETHYLIDENE]HYDRAZINYL] 6 METHYLPYRIMIDIN 4(3H)ONE; 2 [2 [1 (5 BROMOTHIOPHEN 2 YL)ETHYLIDENE]HYDRAZINYL] 6 PHENYLPYRIMIDIN 4(3H)ONE; 2 [2 [BIS(4 FLUOROPHENYL)METHYLENE]HYDRAZINYL] 6 METHYLPYRIMIDIN 4(3H)ONE; 2 [2 [BIS(4 FLUOROPHENYL)METHYLENE]HYDRAZINYL] 6 PHENYLPYRIMIDIN 4(3H)ONE; 6 METHYL 2 [2 [1 (THIOPHEN 2 YL)ETHYLIDENE] HYDRAZINYL] PYRIMIDIN 4(3H)ONE; 6 PHENYL 2 [2 [1 (THIOPHEN 2 YL)ETHYLIDENE]HYDRAZINYL]PYRIMIDIN 4(3H)ONE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; PIRITREXIM; PYRIMIDINE DERIVATIVE; TRIMETHOPRIM; TRIMETREXATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; IC 50; LIVER; MYCOBACTERIUM AVIUM; NONHUMAN; ONE POT SYNTHESIS; PNEUMOCYSTIS CARINII; RAT; SUBSTITUTION REACTION; THIN LAYER CHROMATOGRAPHY; TOXOPLASMA GONDII;

EID: 77953010984     PISSN: 0022152X     EISSN: 19435193     Source Type: Journal    
DOI: 10.1002/jhet.216     Document Type: Article

References (12)

1. Bag, S.; Tawari, N. R.; Degani, M. S. QSAR & Combi Sci 2008, 28, 296.
2. Gangjee, A.; Kurup, S.; Namjoshi, O. Curr Pharm Design 2007, 13, 609.
3. Gschwend, D. A.; Sirawaraporn, W.; Santi, D. V.; Kuntz, I. D. Proteins 1997, 29, 59.
4. Glide, Version 4.5, Schrödinger, LLC, New York, 2008.
5. Cody, V.; Galitsky, N.; Luft, J.; Pangborn, W.; Rosowsky, A.; Queener, S. F. Acta Cryst D 2002, 58, 946.
6. Szilágyi, L.; Illyés, T. Z.; Györgydeák, Z.; Szabó , G.; Karácsony, A. Arkivoc 2004, vii, 243.
7. Bower, J. D.; Doyle, F. P. J Chem Soc 1957, 727.
8. Cooper, M. J.; Hull, R.; Wardleworth, M. J Chem Soc Perkin Trans 1 1975, 1433.
9. Bag, S.; Vaze, V. V.; Degani, M. S. J Chem Res 2006, 4, 267.
10. Broughton, M. C.; Queener, S. F. Antimicrob Agents Chemother 1991, 35, 1348.
11. Chio, L.C.; Queener, S. F. Antimicrob Agents Chemother 1993, 37, 1914.
12. Gangjee, A.; Yang, J.; Queener, S. F. Bioorg Med Chem 2006, 14, 8341.