Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Mitsuishi, Tsuyoshi ^a   Iwabu, Yukie ^b   Tokunaga, Kenzo ^b   Sata, Tetsutaro ^b   Kaneko, Takehiko ^c   Ohara, Kuniaki ^d   Ohsawa, Ikuroh ^e   Oda, Fumino ^a   Yamada, Yuko ^a   Kawana, Seiji ^a   Ozaki, Kohji ^f   Nakatake, Mayuka ^f   Yamada, Osamu ^f  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c Fraternity Memorial Hospital Tokyo   (Japan)

^d TORANOMON HOSPITAL   (Japan)

^e NIPPON MEDICAL SCHOOL GRADUATE SCHOOL OF MEDICINE   (Japan)

^f TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; INITIATION FACTOR 4E BINDING PROTEIN 1; MESSENGER RNA; MYC PROTEIN; PROTEIN KINASE B; PROTEIN S6; TELOMERASE; X LINKED INHIBITOR OF APOPTOSIS; BIRC2 PROTEIN, HUMAN; BIRC3 PROTEIN, HUMAN; CELL CYCLE PROTEIN; EIF4EBP1 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; MYC PROTEIN, HUMAN; PHOSPHOPROTEIN; S6 KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; XIAP PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BOWENOID PAPULOSIS; CELL GROWTH; CELL PROLIFERATION; CONDYLOMA ACUMINATUM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FAMILY; REGULATORY MECHANISM; UPREGULATION; WART VIRUS; ANUS TUMOR; BOWEN DISEASE; CHEMISTRY; FEMALE GENITAL TRACT TUMOR; GENETICS; IMMUNOHISTOCHEMISTRY; JAPAN; MALE; MALE GENITAL TRACT TUMOR; METABOLISM; PAPILLOMAVIRUS INFECTION; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN TUMOR; VIROLOGY; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANUS NEOPLASMS; APOPTOSIS; BLOTTING, WESTERN; BOWEN'S DISEASE; CELL CYCLE PROTEINS; CELL PROLIFERATION; CONDYLOMATA ACUMINATA; FEMALE; GENITAL NEOPLASMS, FEMALE; GENITAL NEOPLASMS, MALE; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBITOR OF APOPTOSIS PROTEINS; JAPAN; MALE; PAPILLOMAVIRUS INFECTIONS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEIN S6 KINASES; RNA, MESSENGER; SKIN NEOPLASMS; TELOMERASE; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 77952983717     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-118     Document Type: Article

References (35)

1. Yamada O, Oshimi K, Motoji T, Mizoguchi H. Telomeric DNA in normal and leukemic blood cells. J Clin Invest 1995, 95:1117-1123. 10.1172/JCI117759, 441448, 7883960.
2. Bearss DJ, Hurley LH, Von Hoff DD. Telomere maintenance mechanisms as a target for drug development. Oncogene 2000, 19:6632-41. 10.1038/sj.onc.1204092, 11426649.
3. Kawauchi K, Ihjima K, Yamada O. IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells. J Immunol 2005, 174:5261-5269.
4. Mergny JL, Riou JF, Mailliet P, Teulade-Fichou MP, Gilson E. Natural and pharmacological regulation of telomerase. Nucleic Acids Res 2002, 30:839-65. 10.1093/nar/30.4.839, 100331, 11842096.
5. Yamada O, Ozaki K, Nakatake M, Akiyama M, Kawauchi K, Matsuoka R. Multistep regulation of telomerase during differentiation of HL60 cells. J Leukoc Biol 2008, 83:1240-1248. 10.1189/jlb.1207848, 18276798.
6. Parris CN, Jezzard S, Silver A, MacKie R, McGregor JM, Newbold RF. Telomerase activity in melanoma and non-melanoma skin cancer. Br J Cancer 1999, 79:47-53. 10.1038/sj.bjc.6690010, 2362177, 10408692.
7. Dong CK, Masutomi K, Hahn WC. Telomerase: regulation, function and transformation. Crit Rev Oncol Hematol 2005, 54:85-93. 10.1016/j.critrevonc.2004.12.005, 15843091.
8. Majewski S, Jablonska S. Human papillomavirus-associated tumors of the skin and mucosa. J Am Acad Dermatol 1997, 36:659-685. 10.1016/S0190-9622(97)80315-5, 9146528.
9. Rolighed J, Sørensen IM, Jacobsen NO, Lindeberg H. The presence of HPV types 6/11, 13, 16 and 33 in bowenoid papulosis in an HIV-positive male, demonstrated by DNA in situ hybridization. APMIS 1991, 99:583-585. 10.1111/j.1699-0463.1991.tb01230.x, 1648931.
10. Pala S, Poleva I, Vocatura A. The presence of HPV types 6/11, 16/18, 31/33/51 in Bowenoid papulosis demonstrated by DNA in situ hybridization. Int J STD AIDS 2000, 11:823-824. 10.1258/0956462001915219, 11138919.
11. Veldman T, Liu X, Yuan H, Schlegel R. Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc Natl Acad Sci USA 2003, 100:8211-8216. 10.1073/pnas.1435900100, 166208, 12821782.
12. Rojo F, Najera L, Lirola J, Jiménez J, Guzmán M, Sabadell MD, Baselga J, Ramon y Cajal S. 4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis. Clin Cancer Res 2007, 13:81-89. 10.1158/1078-0432.CCR-06-1560, 17200342.
13. Toker A, Yoeli-Lerner M. Akt signaling and cancer: surviving but not moving on. Cancer Res 2006, 66:3963-3966. 10.1158/0008-5472.CAN-06-0743, 16618711.
14. Blume-Jensen P, Hunter T. Oncogenic kinase signaling. Nature 2001, 411:355-365. 10.1038/35077225, 11357143.
15. Heesom KJ, Gampel A, Mellor H, Denton RM. Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1). Curr Biol 2001, 11:1374-1379. 10.1016/S0960-9822(01)00422-5, 11553333.
16. Topisirovic I, Ruiz-Gutierrez M, Borden KL. Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities. Cancer Res 2004, 64:8639-8642. 10.1158/0008-5472.CAN-04-2677, 15574771.
17. Kasof GM, Gomes BC. Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem 2001, 276:3238-3246. 10.1074/jbc.M003670200, 11024045.
18. Tamm I, Richter S, Scholz F, Schmelz K, Oltersdorf D, Karawajew L, Schoch C, Haferlach T, Ludwig WD, Wuchter C. XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis. Hematol J 2004, 5:489-495. 10.1038/sj.thj.6200549, 15570290.
19. Yang L, Cao Z, Yan H, Wood WC. Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy. Cancer Res 2003, 63:6815-6824.
20. Liu SS, Tsang BK, Cheung AN, Xue WC, Cheng DK, Ng TY, Wong LC, Ngan HY. Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma. Eur J Cancer 2001, 37:1104-1110. 10.1016/S0959-8049(01)00085-5, 11378340.
21. Espinosa M, Cantu D, Herrera N, Lopez CM, De la Garza JG, Maldonado V, Melendez-Zajgla J. Inhibitors of apoptosis proteins in human cervical cancer. BMC Cancer 2006, 6:1-10. 10.1186/1471-2407-6-45, 1334209, 16390557.
22. Yuan H, Fu F, Zhuo J, Wang W, Nishitani J, An DS, Chen IS, Liu X. Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis. Oncogene 2005, 24:5069-5078. 10.1038/sj.onc.1208691, 15856013.
23. Nakatake M, Sasaki N, Murakami-Murofushi K, Yamada O. Transient posttranslational up-regulation of telomerase activity during megakaryocytic differentiation of K562 cells. Biochem Biophys Res Commun 2004, 31:1080-1085.
24. Yamada O, Akiyama M, Kawauchi K, Adachi T, Yamada H, Kanda N, Aikawa E. Overexpression of telomerase confers a survival advantage through suppression of TRF1 gene expression while maintaining differentiation characteristics in K562 cells. Cell Transplant 2003, 12:365-377.
25. Nakatake M, Kakiuchi Y, Sasaki N, Murakami-Murofushi K, Yamada O. STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells. Cell Cycle 2007, 6:1496-1501.
26. Kinomoto M, Kanno T, Shimura M, Ishizaka Y, Kojima A, Kurata T, Sata T, Tokunaga K. All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition. Nucleic Acids Res 2007, 35:2955-2964. 10.1093/nar/gkm181, 1888823, 17439959.
27. Nagata N, Iwata N, Hasegawa H, Fukushi S, Harashima A, Sato Y, Saijo M, Taguchi F, Morikawa S, Sata T. Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice. Am J Pathol 2008, 172:1625-1637. 10.2353/ajpath.2008.071060, 2408422, 18467696.
28. Tsuji A, Wakisaka N, Kondo S, Murono S, Furukawa M, Yoshizaki T. Induction of receptor for advanced glycation end products by EBV latent membrane protein 1 and Its correlation with angiogenesis and cervical lymph node metastasis in nasopharyngeal carcinoma. Clin Cancer Res 2008, 14:5368-5375. 10.1158/1078-0432.CCR-08-0198, 18765528.
29. Mitsuishi T, Sata T, Matsukura T, Iwasaki T, Kawashima M. The presence of mucosal human papillomavirus in Bowen's disease of the hands. Cancer 1997, 79:1911-1917. 10.1002/(SICI)1097-0142(19970515)79:10<1911::AID-CNCR11>3.0.CO;2-Y, 9149017.
30. Yoshikawa H, Kawana T, Kitagawa K, Mizuno M, Yoshikura H, Iwamoto A. Detection and typing of multiple genital human papillomaviruses by DNA amplification with consensus primers. Jpn J Cancer Res 1991, 82:524-531.
31. Hiyama K, Hirai Y, Kyoizumi S, Akiyama M, Hiyama E, Piatyszek MA, Shay JW, Ishioka S, Yamakido M. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 1995, 155:3711-3715.
32. Schimmer AD. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res 2004, 64:7183-7190. 10.1158/0008-5472.CAN-04-1918, 15492230.
33. Nachmias B, Ashhab Y, Ben-Yehuda D. The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer. Semin Cancer Biol 2004, 14:231-243. 10.1016/j.semcancer.2004.04.002, 15219616.
34. Serra V, Markman B, Scaltriti M, Eichhorn PJ, Valero V, Guzman M, Botero ML, Llonch E, Atzori F, Di Cosimo S, Maira M, Garcia-Echeverria C, Parra JL, Arribas J, Baselga J. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008, 68:8022-8030. 10.1158/0008-5472.CAN-08-1385, 18829560.
35. Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 2007, 273:14484-14494.