Immune recovery after autologous stem cell transplantation is not different for HIV-infected versus HIV-uninfected patients with relapsed or refractory lymphoma

Clinical Infectious Diseases

Volumn 50, Issue 12, 2010, Pages 1672-1679

  Simonelli, Cecilia ^a   Zanussi, Stefania ^a   Pratesi, Chiara ^a   Rupolo, Maurizio ^a   Talamini, Renato ^a   Caffau, Cristina ^a   Bortolin, Maria Teresa ^a   Tedeschi, Rosamaria ^a   Basaglia, Giancarlo ^a   Mazzucato, Mario ^a   Manuele, Rosa ^a   Vaccher, Emanuela ^a   Spina, Michele ^a   Tirelli, Umberto ^a   Michieli, Mariagrazia ^a   De Paoli, Paolo ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIVIRUS AGENT; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; MEPREDNISONE; MESNA; MITOXANTRONE; PREDNISOLONE; PREDNISONE; RITUXIMAB; VINCRISTINE; VIRUS DNA;

ADULT; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BACTERIAL INFECTION; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER RELAPSE; CANCER RESISTANCE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DRUG MEGADOSE; FEMALE; FOLLOW UP; HODGKIN DISEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION COMPLICATION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; MULTIPLE CYCLE TREATMENT; MYCOSIS; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS LOAD; VIRUS REPLICATION;

ADULT; ANTINEOPLASTIC AGENTS; CD4 LYMPHOCYTE COUNT; FEMALE; HIV INFECTIONS; HUMANS; IMMUNE SYSTEM; LYMPHOMA; MALE; MIDDLE AGED; RECURRENCE; REGENERATION; SALVAGE THERAPY; STEM CELL TRANSPLANTATION; THYMUS GLAND; TRANSPLANTATION, AUTOLOGOUS; VIRAL LOAD;

EID: 77952978551     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/652866     Document Type: Article

References (37)

1. Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998;338:853-860.
2. Kirk O, Pedersen Q Cozzi-Lepri A, et al. Non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy. Blood 2001;98:3406-3412.
3. Martinez E, Milinkovic A, Buira E, et al. Incidence and causes of death in HIV-infected persons receiving highly active antiretroviral therapy compared with estimates for the general population of similar age and from the same geographical area. HIV Med 2007;8:251-258.
4. Antiretroviral Therapy Cohort Collaboration (ART-CC). Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy not all AIDS-defining conditions are created equal. Clin Infect Dis 2009;48:1138-1151.
5. Biggar RJ, Jaffe ES, Goedert JJ, et al. Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS. Blood 2006; 108:3786-3791.
6. Philip T, Guglielmi C, Hagenbeek A, et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. N Engl J Med 1995; 333:1540-1545.
7. Nademanee A, Molina A, O'Donnell MR, et al. Results of high-dose therapy and autologous bone marrow/stem cell transplantation during remission in poor-risk intermediate- and high-grade lymphoma: international index high and high-intermediate risk group. Blood 1997; 90: 3844-3852.
8. Molina A, Krishnan AY, Nademanee A, et al. High dose therapy and autologous stem cell transplantation for human immunodeficiency virus-associated non-Hodgkin lymphoma in the era of highly active antiretroviral therapy. Cancer 2000; 89:680-689.
9. Re A, Cattaneo C, Michieli M, et al. High-dose therapy and autologous peripheral-blood stem-cell transplantation as salvage treatment for HIV-associated lymphoma in patients receiving highly active antiretroviral therapy. J Clin Oncol 2003;21:4423-4427.
10. Gabarre J, Marcelin AG, Azar N, et al. High-dose therapy plus autologous hematopoietic stem cell transplantation for human immunodeficiency virus (HIV)-related lymphoma: results and impact on HIV disease. Haematologica 2004;89:1100-1108. (Pubitemid 39295481)
11. Krishnan A, Molina A, Zaia J, et al. Durable remissions with autologous stem cell transplantation for high-risk HIV-associated lymphomas. Blood 2005; 105:874-878. (Pubitemid 40070778)
12. Simonelli C, Michieli M. Autologous stem cell transplantation for HIV-infected individuals with relapsed lymphomas: no longer an experimental strategy. Blood 2005; 105:439-440.
13. Balsalobre P, Díez-Martín JL, Re A, et al. Autologous stem-cell transplantation in patients with HIV-related lymphoma. J Clin Oncol 2009; 27:2192-2198 [erratum in: J Clin Oncol 2009;27:3263].
14. Díez-Martín JL, Balsalobre P, Re A, et al. Comparable survival between HIV+ and HIV- non-Hodgkin and Hodgkin lymphoma patients undergoing autologous peripheral blood stem cell transplantation. Blood 2009; 113(23):6011-6014.
15. Markert ML, Alvarez-McLeod AP, Sempowski GD, et al. Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy. AIDS Res Hum Retroviruses 2001; 17:1635-1643. (Pubitemid 34072819)
16. Franco JM, Rubio A, Martínez-Moya M, et al. T-cell repopulation and thymic volume in HIV-1-infected adult patients after highly active antiretroviral therapy. Blood 2002; 99:3702-3706. (Pubitemid 34534541)
17. Touloumi G, Pantazis N, Karafoulidou A, et al. Changes in T cell receptor excision DNA circle (TREC) levels in HIV type 1-infected subjects preand post-highly active antiretroviral therapy. AIDS Res Hum Retroviruses 2004;20:47-54. (Pubitemid 38147176)
18. Pratesi C, Simonelli Q Zanussi S, et al. Recent thymic emigrants in lymphoma patients with and without human immunodeficiency virus infection candidates for autologous peripheral stem cell transplantation. Clin Exp Immunol 2008; 151:101-109. (Pubitemid 350230979)
19. Klebanoff CA, Khong HT, Antony PA, Palmer DC, Restifo NP. Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy. Trends Immunol 2005; 26:111-117.
20. Muranski P, Boni A, Wrzesinski C, et al. Increased intensity lymphodepletion and adoptive immunotherapy-how far can we go? Nat Clin Pract Oncol 2006;3:668-681.
21. Bortolin MT, Simonelli Q Zanussi S, et al. Effects on virological and immunological parameters during CD34 mobilization in HIV patients with lymphoma. Am J Hematol 2006;81:800-802.
22. Bortolin MT, Zanussi S, Salamini R, et al. Predictive value of HIV-1 DNA levels on overall survival in HIV-related lymphoma patients treated with high dose chemotherapy (HDC) plus autologous stem cell transplantation (ASCT). AIDS Res Hum Retrov 2010;26:245-251.
23. Common toxicity criteria, version 2.0: cancer therapy evaluation program 1. Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, and Department of Health and Human Services, 1999. http://ctep.cancer.gov/protocoldevelopment/electronic-applications/docs/ ctcv20-4-30-992.pdf.
24. Sempowski G, Thomasch J, Gooding M, et al. Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis. J Immunol 2001; 166:2808-2817. (Pubitemid 32173522)
25. Santagostino A, Garbaccio G, Pistorio A, et al. An Italian national multicenter study for the definition of reference ranges for normal values of peripheral blood lymphocyte subsets in healthy adults. Haematologica 1999; 84:499-504. (Pubitemid 29323257)
26. Resino S, Pérez A, Seoane E, et al. Short communication: immune reconstitution after autologous peripheral blood stem cell transplantation in HIV-infected patients: might be better than expected? AIDS Res Hum Retroviruses 2007; 23:543-548.
27. Benicchi T, Ghidini C, Re A, et al. T-cell immune reconstitution after hematopoietic stem cell transplantation for HIV-associated lymphoma. Transplantation 2005; 80:673-682. (Pubitemid 41377757)
28. Mackali CL. T-cell immunodeficiency following cytotoxic antineoplastic therapy: a review. Stem Cells 2000; 18:10-18.
29. Kolte L, Dreves AM, Ersboll AK, et al. Association between larger thymic size and higher thymic output in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy. J Infect Dis 2002; 185:1578-1585. (Pubitemid 34587519)
30. Guillaume T, Rubinstein DB, Symann M. Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation. Blood 1998;92:1471-1490. (Pubitemid 28406849)
31. Sportes C, McCarthy NJ, Hakim F, et al. Establishing a platform for immunotherapy: clinical outcome and study of immune reconstitution after high-dose chemotherapy with progenitor cell support in breast cancer patients. Biol Blood Marrow Transplant 2005; 11:472-483. (Pubitemid 40753800)
32. Te Boekhorst PA, Lamers CH, Schipperus MR, et al. T-lymphocyte reconstitution following rigorously T-cell-depleted versus unmodified autologous stem cell transplants. Bone Marrow Transplant 2006; 37:763-772.
33. Buser A, Stern M, Arber C, et al. Impaired B-cell reconstitution in lymphoma patients undergoing allogeneic HSCT: an effect of pretreatment with rituximab? Bone Marrow Transplant 2008; 42:483-487.
34. Malphettes M, Carcelain G, Saint-Mezard P, et al. Evidence for naive T-cell repopulation despite thymus irradiation after autologous transplantation in adults with multiple myeloma: role of ex vivo CD34+ selection and age. Blood 2003; 101:1891-1897. (Pubitemid 36237590)
35. Chen BJ, Cui X, Sempowski GD, Domen J, Chao NJ. Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. Blood 2004; 103:4344-4352. (Pubitemid 38685383)
36. Douek DC, Vescio RA, Betts MR, et al. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet 2000;355:1875-1881.
37. Rutella S, Rumi C, Laurenti L, et al. Immune reconstitution after transplantation of autologous peripheral CD34+ cells: analysis of predictive factors and comparison with unselected progenitor transplants. Br J Haematol 2000; 108:105-115. (Pubitemid 30089942)