Effects of Adiposity and 30 Days of Caloric Restriction Upon Protein Metabolism in Moderately vs. Severely Obese Women

Obesity

Volumn 18, Issue 6, 2010, Pages 1135-1142

  Henderson, Gregory C ^a   Nadeau, Daniel ^b   Horton, Edward S ^c   Nair, K Sreekumaran ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; CARBON 13; GLUTAMIC ACID; GLYCINE; HISTIDINE; INSULIN; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; PHENYLALANINE; SERINE; THREONINE; TYROSINE; VALINE; AMINO ACID; HORMONE; PROTEIN;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BODY MASS; BODY WEIGHT; CALORIC RESTRICTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; FAT FREE MASS; FAT MASS; FEMALE; HUMAN; INSULIN BLOOD LEVEL; LEUCINE OXIDATION; LEUCINE RATE OF APPEARANCE; METABOLIC RATE; MODERATE OBESITY; NONOXIDATIVE LEUCINE DISPOSAL; OBESITY; PROTEIN INTAKE; PROTEIN METABOLISM; RESTING ENERGY EXPENDITURE; SEVERE OBESITY; BASAL METABOLIC RATE; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; HOSPITALIZATION; METABOLISM; MIDDLE AGED; MORBID OBESITY; PHYSIOLOGY; PROTEIN SYNTHESIS; TIME; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADIPOSITY; ADULT; AMINO ACIDS; BASAL METABOLISM; CALORIC RESTRICTION; FEMALE; HORMONES; HUMANS; MIDDLE AGED; OBESITY; OBESITY, MORBID; PROTEIN BIOSYNTHESIS; PROTEINS; SEVERITY OF ILLNESS INDEX; TIME FACTORS; YOUNG ADULT;

EID: 77952956362     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2009.505     Document Type: Article

References (42)

1. Welle S, Nair KS,. Relationship of resting metabolic rate to body composition and protein turnover. Am J Physiol 1990; 258: E990-E998.
2. Jensen MD, Haymond MW,. Protein metabolism in obesity: effects of body fat distribution and hyperinsulinemia on leucine turnover. Am J Clin Nutr 1991; 53: 172-176.
3. Welle S, Statt M, Barnard R, Amatruda J,. Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women. Metabolism 1994; 43: 441-445.
4. Chevalier S, Burgess SC, Malloy CR, et al., The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism. Diabetes 2006; 55: 675-681.
5. Welle S, Barnard RR, Statt M, Amatruda JM,. Increased protein turnover in obese women. Metab Clin Exp 1992; 41: 1028-1034.
6. Halvatsiotis P, Short KR, Bigelow M, Nair KS,. Synthesis rate of muscle proteins, muscle functions, and amino acid kinetics in type 2 diabetes. Diabetes 2002; 51: 2395-2404.
7. Caballero B, Wurtman RJ,. Differential effects of insulin resistance on leucine and glucose kinetics in obesity. Metabolism 1991; 40: 51-58.
8. Solini A, Bonora E, Bonadonna R, Castellino P, DeFronzo RA,. Protein metabolism in human obesity: relationship with glucose and lipid metabolism and with visceral adipose tissue. J Clin Endocrinol Metab 1997; 82: 2552-2558.
9. Luzi L, Castellino P, DeFronzo RA,. Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity. Am J Physiol 1996; 270: E273-E281.
10. Nair KS, Halliday D, Ford GC, Garrow JS,. Effect of triiodothyronine on leucine kinetics, metabolic rate, glucose concentration and insulin secretion rate during two weeks of fasting in obese women. Int J Obes 1989; 13: 487-496.
11. Hoffer LJ, Forse RA,. Protein metabolic effects of a prolonged fast and hypocaloric refeeding. Am J Physiol 1990; 258: E832-E840.
12. Kanaley JA, Haymond MW, Jensen MD,. Effects of exercise and weight loss on leucine turnover in different types of obesity. Am J Physiol 1993; 264: E687-E692.
13. van Gemert WG, Westerterp KR, van Acker BA, et al., Energy, substrate and protein metabolism in morbid obesity before, during and after massive weight loss. Int J Obes Relat Metab Disord 2000; 24: 711-718.
14. Gallagher D, Kovera AJ, Clay-Williams G, et al., Weight loss in postmenopausal obesity: no adverse alterations in body composition and protein metabolism. Am J Physiol 2000; 279: E124-E131.
15. Walrand S, Short KR, Bigelow ML, et al., Functional impact of high protein intake on healthy elderly people. Am J Physiol Endocrinol Metab 2008; 295: E921-E928.
16. Pannemans DL, Halliday D, Westerterp KR, Kester AD,. Effect of variable protein intake on whole-body protein turnover in young men and women. Am J Clin Nutr 1995; 61: 69-74.
17. Howard AN, Baird I McLean,. Very low calorie semi-synthetic diets in the treatment of obesity. An inpatient/outpatient study. Nutr Metab 1977; 21 Suppl 1: 59-61.
18. Stokholm KH, Jensen GF, Hansen BB, Quaade F,. Very-low-calorie diet in the treatment of massive obesity: preliminary experience. Int J Obes 1980; 4: 213-220.
19. Must A, Spadano J, Coakley EH, et al., The disease burden associated with overweight and obesity. JAMA 1999; 282: 1523-1529.
20. Nair KS, Woolf PD, Welle SL, Matthews DE,. Leucine, glucose, and energy metabolism after 3 days of fasting in healthy human subjects. Am J Clin Nutr 1987; 46: 557-562.
21. Nair KS, Garrow JS, Ford C, Mahler RF, Halliday D,. Effect of poor diabetic control and obesity on whole body protein metabolism in man. Diabetologia 1983; 25: 400-403.
22. Bang P, Eriksson U, Sara V, Wivall IL, Hall K,. Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: improvement of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand. Acta Endocrinol 1991; 124: 620-629.
23. Lilavivathana U, Brodows RG, Woolf PD, Campbell RG,. Counterregulatory hormonal responses to rapid glucose lowering in diabetic man. Diabetes 1979; 28: 873-877.
24. Nair KS, Ford GC, Ekberg K, Fernqvist-Forbes E, Wahren J,. Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients. J Clin Invest 1995; 95: 2926-2937.
25. Schwenk WF, Beaufrere B, Haymond MW,. Use of reciprocal pool specific activities to model leucine metabolism in humans. Am J Physiol 1985; 249: E646-E650.
26. Charlton MR, Adey DB, Nair KS,. Evidence for a catabolic role of glucagon during an amino acid load. J Clin Invest 1996; 98: 90-99.
27. 13C]bicarbonate is transiently increased during recovery from hard exercise. J Appl Physiol 2007; 103: 1604-1612.
28. Issekutz B Jr, Paul P, Miller HI, Bortz WM,. Oxidation of plasma FFA in lean and obese humans. Metab Clin Exp 1968; 17: 62-73.
29. Vazquez JA, Morse EL, Adibi SA,. Effect of dietary fat, carbohydrate, and protein on branched-chain amino acid catabolism during caloric restriction. J Clin Invest 1985; 76: 737-743.
30. Frayn KN,. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 1983; 55: 628-634.
31. Forbes GB, Drenick EJ,. Loss of body nitrogen on fasting. Am J Clin Nutr 1979; 32: 1570-1574.
32. Forbes GB,. Lean body mass-body fat interrelationships in humans. Nutr Rev 1987; 45: 225-231.
33. Prentice AM, Goldberg GR, Jebb SA, et al., Physiological responses to slimming. Proc Nutr Soc 1991; 50: 441-458.
34. Estornell E, Cabo J, Barber T,. Protein synthesis is stimulated in nutritionally obese rats. J Nutr 1995; 125: 1309-1315.
35. Felig P, Marliss E, Cahill GF Jr,. Plasma amino acid levels and insulin secretion in obesity. N Engl J Med 1969; 281: 811-816.
36. Deshmukh A, Salehzadeh F, Metayer-Coustard S, et al., Post-transcriptional gene silencing of ribosomal protein S6 kinase 1 restores insulin action in leucine-treated skeletal muscle. Cell Mol Life Sci 2009; 66: 1457-1466.
37. Kraenzlin ME, Keller U, Keller A, et al., Elevation of plasma epinephrine concentrations inhibits proteolysis and leucine oxidation in man via beta-adrenergic mechanisms. J Clin Invest 1989; 84: 388-393.
38. Miles JM, Nissen SL, Gerich JE, Haymond MW,. Effects of epinephrine infusion on leucine and alanine kinetics in humans. Am J Physiol 1984; 247: E166-E172.
39. Henderson GC, Dhatariya K, Ford GC, et al., Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements. FASEB J 2009; 23: 631-641.
40. Luzi L, Giordano M, Caloni P Castellino,. Effects of insulin and amino acids on leucine metabolism in young and middle-aged humans. Eur J Nutr 2001; 40: 106-112.
41. Nygren J, Nair KS,. Differential regulation of protein dynamics in splanchnic and skeletal muscle beds by insulin and amino acids in healthy human subjects. Diabetes 2003; 52: 1377-1385.
42. Tessari P, Inchiostro S, Barazzoni R, et al., Hyperglucagonemia stimulates phenylalanine oxidation in humans. Diabetes 1996; 45: 463-470.