Hyperglucagonemia stimulates phenylalanine oxidation in humans

Diabetes

Volumn 45, Issue 4, 1996, Pages 463-470

  Tessari, Paolo ^a,b   Inchiostro, Sandro ^a   Barazzoni, Rocco ^a   Zanetti, Michela ^a   Vettore, Monica ^a   Biolo, Gianni ^a   Lori, Elisabetta ^a   Kiwanuka, Edward ^a   Tiengo, Antonio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Istituto di Medicina Clinica Padova   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; PHENYLALANINE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CONTROLLED STUDY; GLUCAGON BLOOD LEVEL; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; HYDROXYLATION; MALE; NORMAL HUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION;

EID: 0029971221     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.4.463     Document Type: Article

References (62)

1. Unger RH: Glucagon and Insulin: glicagon ratio in diabetes and other catabolic illnesses Diabetes 20:834-838, 1972
2. Gerich JE, Lorenzi M, Tsalikian E, Karam JH: Studies on the mechanisms of epinephrine-induced hyperglycemia in man. Diabetes 25:67-71, 1976
3. Bolli GB, Gale EAM: Hypoglycemia. In International Textbook of Diabetes Mellitus. Alberti KGMM, De Fronzo RA, Keen H, Zimmet P, Eds. New York, Wiley, 1992, p. 1131-1150
4. Russel RCG, Walker CJ, Bloom SR: Hyperglucagonemia in the surgical patient. Br Med J 1:10-12, 1975
5. Rocha DM, Santeusanio F, Faloona GR, Unger RH: Abnormal pancreatic alpha-cell function in bacterial infections. N Engl Med J 288-700-703, 1973
6. G. Wilmore DW, Moylan JA, Pruitt BA, Lindsey CA, Faloona GR, Unger RH: Hyperglucagonemia after burns. Lancet i:73-75, 1974
7. Meguid MM, Brennan MF, Aoki TT, Muller WA, Ball MR, Moore FD: Hormone substrate interrelationships following trauma. Arch Surg 109: 776-783, 1974
8. Cherrington AD, Lacy WW, Chiasson JL: Effect, of glucagon on glucose production during insulin-deficiency in the dog. J Clin Invest 62:664-677, 1978
9. Jennings AS, Cherrington AD, Liljienquist JE, Keller U, Lacy WW, Chiasson JL: The roles of insulin and glucagon in the regulation of gluconeogenesis in the postabsorptive dog. Diabetes 26:847-856, 1977
10. Gerich JE, Lorenzi M, Bier DM, Tsalikian E, Schneider V, Karam JH, Forsham PH: Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. J Clin Invest 57:875-884, 1970
11. Miles JM, Haymond MW, Nissen SL, Gerich JE- Effects of free-fatty acid availability, glucagon excess, and insulin deficiency on ketone body production in postabsorptive man. J Clin Invest 71:1554-1561, 1983
12. Holst JJ: Glucagon: how to prove its role in amino acid metabolism. Eur J Clin Invest 13:107-108, 1983
13. Carr FPA, Pogson CI: Phenylalanine metabolism in isolated rat liver cells: effects of glucagon and diabetes. Biochem J 198:655-660, 1981
14. Fisher MJ, Dickson AJ, Pogson CI: The role of insulin in the modulation of glucagon-dependent control of phenylalanine hydroxylation in isolated liver cells. Biochem J 242:655-660, 1987
15. Buse MG, Biggers JF, Drier C, Buse JF: The effect of epinephrine, glucagon, and the nutritional state on the oxidation of branched chain amino acids and pyruvate by isolated hearts and diaphragms of the rat. J Biol Chem 248:697-706, 1973
16. Fehlman MA, Le Cam A, Freychet P: Insulin and glucagon stimulation of amino acid transport in isolated rat hepatocytes. synthesis of a high affinity component of transport J Biol Chem 254:10431-10437, 1979
17. Preedy VR, Garlick PJ: The effect of glucagon administration on protein synthesis in skeletal muscles, heart and liver in vivo. Biochem J 228:575-581, 1985
18. Boden G, Rezvani I, Owen OE: Effects of glucagon on plasma amino acids J Clin Invest 73:785-793, 1984
19. Landau RL, Lugibihl K. Effect of glucagon on concentration of several free amino acids in plasma. Metabolism 18:265-271, 1969
20. Bier DM: Intrinsically difficult problems: the kinetics of body proteins and amino acids in man. Diabetes Metab Rev 5:111-132, 1989
21. Almdal TP, Vilstrup H: Loss of nitrogen from organs in rats induced by exogenous glucagon. Endocrinology 123:2182-2186, 1988
22. Boden G, Tappy L, Jadali F, Hoeldtke RD, Rezvani I, Owen OE: Role of glucagon in disposal of an amino acid load. Am J. Physiol 259:E225-E232, 1990
23. Ostaszewski P, Nissen S: Effect of hyperglucagonemia on whole-body leucine metabolism in immature pigs before and during a meal. Am J Physiol 254,E372-E377, 1988
24. Couet C, Fukagawa NK, Matthews DE, Bier DM, Young VR: Plasma amino acid kinetics during acute states of glucagon deficiency and excess in healthy adults. Am J Physiol 258 E78-E85, 1990
25. Nair SK, Halliday D, Matthews DE, Welle SW: Hyperglucagonemia during insulin deficiency accelerates protein catabolism. Am J Physiol 253: E208-E213, 1987
26. Hartl WH, Miyoshi H, Jahoor F, Klein S, Elahi D, Wolfe RR: Bradykinin attenuates glucagon-induced leucine oxidation in humans. Am J Physiol 259:E239-E245, 1990
27. Charlton MR, Nair KS: The effect of amino acid infusion on protein metabolism: the role of glucagon (Abstract). Diabetologia 38:23A, 1995
28. Krebs HA, Lund P: Aspects of the regulation of the metabolism of branched-chain amino acids Adv Enzyme Regul 15:375-394, 1977
29. Rosenberg LE, Scriver CR: Disorders of amino acid metabolism. In Metabolic Control and Disease, Bondy PK, Rosenberg LE, Eds. Philadelphia, Saunders, 1980, p. 707-710
30. Tessari P, Inchiostro S, Vettore M, Sabadin L, Biolo G: A fast HPLC method for the measurement of plasma concentration and specific activity of phenylalanine. Clin Biochem 24:425-428, 1991
31. Nissen SL, Van Huysen C, Haymond MW: Measurement of branched-chain amino acids and branched-chain α-ketoacids in plasma by high-performance liquid chromatography. J Chromatogr 232:170-175, 1982
32. Schwenk WF, Berg PJ, Beaufrere B, Miles JM, Raymond MW: Use of t-butyldimethylsilylation in the GC/MS analysis of physiologic compounds found in plasma using electron impact ionization. Anal Biochem 141:101-109, 1984
33. Tessari P, Inchiostro S, Biolo G. Trevisan R, Fantin G, Marescotti MC, Ion E, Tiengo A, Crepaldi G: Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. J Clin Invest 79:1062-1069, 1987
34. Kuzuya T, Matzuda JS, Yoshida S: Human C-peptide immunoreactivity (CPR) in blood and urine: evaluation of a RIA method and its clinical application Diabetologia 12:511-518, 1976
35. Peake GT: Growth hormone. In Methods of Hormone Radioimmunoassay Jeffe B, Behrman H, Eds. New York, Academic, 1974, p. 103-121
36. 5]phenylalanine model Am J Physiol 256:E631-E639, 1989
37. 14C]tyrosine. Clin Sci Mol Med 50:525-532, 1976
38. 13C]tyrosine. in the postabsorptive state. Metabolism 31.999-1005, 1982
39. 13C]phenylalanine as tracers in man. Metabolism 42 1316-1322, 1993
40. Cortiella J, Marchini JS, Branch S, Chapman TE, Young VR: Phenylalanine and tyrosine kinetics in relation to altered protein and phenylalanine and tyrosine intakes in healthy young men. Am J Clin Nutr 56:517-525, 1992
41. Schwenk WF, Beaufrere B, Haymond MW: Use of reciprocal pool specific activities to model leucine metabolism in man. Am J Physiol 249:E646-E650, 1985
42. Parhofer KG, Hugh P, Barrett R, Bier DM, Schonfeld G: Determination of kinetic parameters of apolipoprotein B metabolism using amino acids labeled with stable isotopes. J Lipid Res 32:1311-1323, 1991
43. De Feo PP, Volpi E, Lucidi P, Cruciani G, Monacchia F, Reboldi G, Santeusanio F, Bolli GB, Brunetti P: Ethanol impairs post-prandial hepatic protein metabolism. J Clin Invest 95:1472-1479, 1995
44. Reeds PJ, Hachey DL, Patterson BW, Motil KJ, Klein PD: VLDL apolipoprotein B-100, a potential indicator of the isotopic labeling of the hepatic protein synthetic precursor pool in humans: studies with multiple stable isotopically labeled amino acids J Nutr 122:457-466, 1992
45. Tessari P, Trevisan R, Inchiostro S, Vigili de Kreutzenberg S, Biolo G, Nosadini R, Duner E, Tiengo A, Crepaldi G: Dose-response curves of the effects of insulin on leucine kinetics in man. Am J Physiol 251:E334-E343, 1986
46. Fukagawa NK, Minaker KL, Rowe JW, Goodman MN, Matthews DE, Bier DE, Young VR: Insulin-mediated reduction of whole-body protein break-down: dose-response effects on leucine metabolism. J Clin Invest 76-2306-2311, 1985
47. Louard RJ, Fryburg DA, Gelfand RA, Barrett EJ: Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle. J Clin Invest 90:2348-2354, 1992
48. Heiling VJ, Campbell PJ, Gottesman IS, Tsalikian E, Beaufrere B, Gerich JE, Haymond MW: Differential effects of hyperglycemia and hyperinsulinemia on leucine rate of appearance in normal humans. J. Clin Endocrinol Metab 76:203-206, 1993
49. Schwenk WF, Tsalikian E, Beaufrere B, Haymond MW: Recycling of an amino acid label with prolonged isotope infusion: implication for kinetic studies. Am J Physiol 248:E482-E487, 1985
50. 15N]leucine infused at low rates on leucine metabolism in humans. Am J Physiol 249:E121-E130, 1985
51. Munro HN, Fleck A: Analysis of tissues and body fluids for nitrogenous constituents. In Mammalian Protein Metabolism. Munro HN, Ed. New York, Academic, 1969, p. 508
52. Waterlow JC, Garlick P, Millward DJ: Protein Turnover in Mammalian Tissues and in the Whole. Body. Amsterdam, North Holland, 1979, p. 120
53. Flakoll PJ, Borel MJ, Wentzel LS, Williams PE, Lacy DB, Abumrad NN: The role of glucagon in the control of protein and amino acid metabolism in vivo. Metabolism 43:1509-1516, 1994
54. Horber FH, Haymond MW: Human growth hormone prevents the protein catabolic side effects of prednisone in humans. J Clin Invest 86:265-272, 1990
55. 3 infused by gut and vein: effect of feeding. Am J Physiol 257:E257-E438, 1989
56. Biolo G, Tessari P, Inchiostro S, Bruttomesso D, Sabadin L, Fongher C, Panebianco G, Fratton MG, Tiengo A: Fasting and post-prandial phenylalanine metabolism in mild type 2 diabetes. Am J Physiol 263:E877-E883, 1992
57. De Feo P, Gaisano MG, Haymond MG: Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans. J Clin invest 88:833-840, 1991
58. 13C]phenylalanine. Am J Physiol 259 E835-E843, 1990
59. Moller N, Jorgensen JOL, Schmitz O, Moller J, Christiansen JS, Alberti KGMM, Orskov H Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. Am J Physiol 258:E86-E91, 1990
60. Fryburg DA, Gelfand RA, Barrett EJ: Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. Am J Physiol 260:E499-E504, 1991
61. Robert JJ, Beaufrere B, Koziet J, Desjeux F, Bier DM, Young VR, Lestradet H: Whole-body de novo amino acid synthesis in type 1 (Insulin-dependent) diabetes studied with stable isotope labeled leucine, alanine, and glycine. Diabetes 34;67-73, 1985
62. Luzi L, Castellino P, Simonson DC, Petrides AS, DeFronzo RA: Leucine metabolism in IDDM: role of insulin and substrate availability. Diabetes 39.38-48, 1990