Cytoplasmic sequestration of p53 promotes survival in leukocytes transformed by Theileria

Oncogene

Volumn 29, Issue 21, 2010, Pages 3079-3086

  Haller, D ^a   MacKiewicz, M ^a   Gerber, S ^a   Beyer, D ^a   Kullmann, B ^a   Schneider, I ^a   Ahmed, J S ^a   Seitzer, U ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Apoptosis; Cytoplasmic sequestration; P53; Theileria annulata

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BUPARVAQUONE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CYTOPLASM; DOWN REGULATION; EPIGENETICS; FEMALE; GENE TRANSLOCATION; HOST CELL; INHIBITION KINETICS; LYMPHOCYTE TRANSFORMATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SCHIZONT; THEILERIA ANNULATA; THEILERIOSIS; UPREGULATION;

ANIMALS; ANTIPROTOZOAL AGENTS; BCL-2-ASSOCIATED X PROTEIN; CATTLE; CELL NUCLEUS; CELL SURVIVAL; CONCANAVALIN A; DNA, COMPLEMENTARY; GENE AMPLIFICATION; KINETICS; LEUKOCYTES; NAPHTHOQUINONES; THEILERIA ANNULATA; THEILERIASIS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

BOVINAE; PROTOZOA; THEILERIA; THEILERIA ANNULATA;

EID: 77952954835     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.61     Document Type: Article

References (39)

1. Adams JM, Cory S. (2002). Apoptosomes: engines for caspase activation. Curr Opin Cell Biol 14: 715-720.
2. Ahmed JS, Rothert M, Steuber S, Schein E. (1989). In vitro proliferative and cytotoxic responses of PBL from Theileria annulata-immune cattle. Zentralbl Veterinarmed B 36: 584-592.
3. Ahmed JS, Schnittger L, Mehlhorn H. (1999). Theileria schizonts induce fundamental alterations in their host cells. Parasitol Res 85: 527-538.
4. Bakheit MA, Endl E, Ahmed JS, Seitzer U. (2006a). Purification of macroschizonts of a Sudanese isolate of Theileria lestoquardi (T. lestoquardi [Atbara]). Ann NY Acad Sci 1081: 453-462.
5. Bakheit MA, Scholzen T, Ahmed JS, Seitzer U. (2006b). Molecular characterization of a Theileria lestoquardi gene encoding for immunogenic protein splice variants. Parasitol Res 100: 161-170.
6. Bosari S, Viale G, Roncalli M, Graziani D, Borsani G, Lee AK et al. (1995). p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma. Am J Pathol 147: 790-798.
7. Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B et al. (1994). Adenovirus E1B 19kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell 79: 341-351.
8. Dobbelaere DA, Prospero TD, Roditi IJ, Eichhorn M, Williams RO. (1988). Theileria parva infection induce autocrine growth of bovine lymphocytes. Proc Natl Acad Sci USA 85: 4730-4734.
9. Fortin A, Cregan SP, MacLaurin JG, Kushwaha N, Hickman ES, Thompson CS et al. (2001). APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol 155: 207-216.
10. Galley Y, Hagens G, Glaser I, Davis W, Eichhorn M, Dobbelaere D. (1997). Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva. Proc Natl Acad Sci USA 94: 5119-5124.
11. Gardner MJ, Bishop R, Shah T, de Villiers EP, Carlton JM, Hall N et al. (2005). Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes. Science 309: 134-137.
12. Guergnon J, Dessauge F, Langsley G, Garcia A. (2003). Apoptosis of Theileria-infected lymphocytes induced upon parasite death involves activation of caspases 9 and 3. Biochemie 85: 771-776.
13. Heussler VT, Kuenzi P, Fraga F, Schwab RA, Hemmings BA, Dobbelaere DA. (2001). The Akt/PKB pathway is constitutively activated in Theileria-transformed leucocytes, but does not directly control constitutive NF-kappaB activation. Cell Microbiol 3: 537-550.
14. Heussler VT, Rottenberg S, Schwab R, Kuenzi P, Fernandez PC, McKellar S, et al. (2002). Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science 298: 1033-1036.
15. Knippschild U, Oren M, Deppert W. (1996). Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion. Oncogene 12: 1755-1765.
16. Lane DP, Crawford LV. (1979). T antigen is bound to a host protein in SV40-transformed cells. Nature 278: 261-263.
17. Levine AJ. (1997). p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
18. Liang SH, Clarke MF. (2001). Regulation of p53 localization. Eur J Biochem 268: 2779-2783.
19. McHardy N, Morgan DW. (1985). Treatment of Theileria annulata infection in calves with parvaquone. Res Vet Sci 39: 1-4.
20. McHardy N, Wekesa LS. (1985). In: Irvin AD (ed). Buparvaquone BW 720C: a new antitheilerial napthoquinone\its role in the therapy and prophylaxis of theileriosis. Immunization Against Theileriosis in Africa. International Laboratory for Research on Animal Diseases: Nairobi, Kenya. pp 88.
21. Miyashita T, Reed JC. (1995). Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299.
22. Moll UM, LaQuaglia M, Benard J, Riou G. (1995). Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci USA 92: 4407-4411.
23. Moll UM, Ostermeyer AG, Haladay R, Winkfield B, Frazier M, Zambetti G. (1996). Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol Cell Biol 16: 1126-1137.
24. Moll UM, Riou G, Levine AJ. (1992). Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci USA 89: 7262-7266.
25. Nikolaev AY, Li M, Puskas N, Qin J, Gu W. (2003). Parc: a cytoplasmic anchor for p53. Cell 112: 29-40.
26. O'Brate A, Giannakakou P. (2003). The importance of p53 location: nuclear or cytoplasmic zip code? Drug Resist Updat 6: 313-322.
27. Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B. (1993). Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 362: 857-860.
28. Pain A, Renauld H, Berriman M, Murphy L, Yeats CA, Weir W et al. (2005). Genome of the host-cell transforming parasite Theileria annulata compared with T. parva. Science 309: 131-133.
29. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. (1990). The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63: 1129-1136.
30. Schlamp CL, Poulsen GL, Nork TM, Nickells RW. (1997). Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells. J Natl Cancer Inst 89: 1530-1536.
31. Schneider I, Haller D, Seitzer U, Beyer D, Ahmed JS. (2004). Molecular genetic characterization and subcellular localization of a putative Theileria annulata membrane protein. Parasitol Res 94: 405-415.
32. Seitzer U, Schnittger L, Boguslawski K, Ahmed JS. (2006). Investigation of MAP kinase activation in Theileria-infected cell lines. Ann NY Acad Sci 1081: 473-475.
33. Shayan P, Gerlach C, Hugel FU, Kay G, Campbell JD, Gerdes J et al. (1999). The proliferation-associated nuclear protein Ki-67 in the bovine system: partial characterisation and its application for determination of the proliferation of Theileria-infected bovine cells. Parasitol Res 85: 613-620.
34. Shimizu S, Narita M, Tsujimoto Y. (1999). Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochon-drial channel VDAC. Nature 399: 483-487.
35. Sun XF, Carstensen JM, Zhang H, Stal O, Wingren S, Hatschek T et al. (1992). Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma. Lancet 340: 1369-1373.
36. Toye P, Nyanjui J, Goddeeris B, Musoke AJ. (1996). Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva. Infect Immun 64: 1832-1838.
37. Ueda H, Ullrich SJ, Gangemi JD, Kappel CA, Ngo L, Feitelson MA et al. (1995). Functional inactivation but not structural mutation of p53 causes liver cancer. Nat Genet 9: 41-47.
38. Vogelstein B, Lane D, Levine AJ. (2000). Surfing the p53 network. Nature 408: 307-310.
39. Wu Y, Mehew JW, Heckman CA, Arcinas M, Boxer LM. (2001). Negative regulation of bcl-2 expression by p53 in hematopoietic cells. Oncogene 20: 240-251.