Substituents effect on the erlenmeyer-plöchl reaction: Understanding an observed process reaction time

Organic Process Research and Development

Volumn 14, Issue 3, 2010, Pages 579-584

  Chavez, Flavio ^a   Kennedy, Nicole ^a   Rawalpally, Thimma ^a   Williamson, R Thomas ^a   Cleary, Thomas ^a  

^a Roche Carolina   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77952934019     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op100032s     Document Type: Article

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32. The proposed intermediate 13 was not detected in our reactions maybe because the HPLC conditions reverted the species 13 back to the probable, more stable intermediate 12. We confirmed the reversibility process of oxazolone 13 by injecting a purchased sample from Aldrich (R = H).