Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cues

Frontiers in Behavioral Neuroscience

Volumn 3, Issue SEP, 2009, Pages

  Sanchis Segura, Carles ^a   Jancic, Dragana ^b   Jimenez Minchan, Maria ^b   Barco, Angel ^b  

^a UNIVERSITAT JAUME I   (Spain)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

Addiction; CREB; Morphine; Place preference; Striatum

Indexed keywords

EID: 77952890875     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/neuro.08.030.2009     Document Type: Article

References (30)

1. Barrot, M., Olivier, J. D., Perrotti, L. I., DiLeone, R. J., Berton, O., Eisch, A. J., Impey, S., Storm, D. R., Neve, R. L., Yin, J. C., Zachariou, V., and Nestler, E. J. (2002). CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc. Natl. Acad. Sci. USA 99, 11435-11440.
2. Bilbao, A., Parkitna, J. R., Engblom, D., Perreau-Lenz, S., Sanchis-Segura, C., Schneider, M., Konopka, W., Westphal, M., Breen, G., Desrivieres, S., Klugmann, M., Guindalini, C., Vallada, H., Laranjeira, R., de Fonseca, F. R., Schumann, G., Schutz, G., and Spanagel, R. (2008). Loss of the Ca22/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proc. Natl. Acad. Sci. USA 105, 17549-17554.
3. Carlezon, W. A. Jr., Duman, R. S., and Nestler, E. J. (2005). The many faces of CREB. Trends Neurosci. 28, 436-445.
4. Carlezon, W. A. Jr., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., and Nestler, E. J. (1998). Regulation of cocaine reward by CREB. Science 282, 2272-2275.
5. Di Ciano, P., Cardinal, R. N., Cowell, R. A., Little, S. J., and Everitt, B. J. (2001). Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior. J. Neurosci. 21, 9471-9477.
6. Domjan, M. (2005). Pavlovian conditioning: a functional perspective. Annu. Rev. Psychol. 56, 179-206.
7. Dong, Y., Green, T., Saal, D., Marie, H., Neve, R., Nestler, E. J., and Malenka, R. C. (2006). CREB modulates excitability of nucleus accumbens neurons. Nat. Neurosci. 9, 475-477.
8. Everitt, B. J., and Robbins, T. W. (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8, 1481-1489.
9. Fasano, S., Pittenger, C., and Brambilla, R. (2009). Inhibition of CREB activity in the dorsal portion of the striatum potentiates behavioral responses to drugs of abuse. Front. Behav. Neurosci. doi: 10.3389/neuro.08.029.2009
10. German, P. W., and Fields, H. L. (2007). Rat nucleus accumbens neurons persistently encode locations associated with morphine reward. J. Neurophysiol. 97, 2094-2106.
11. Green, T. A., Alibhai, I. N., Hommel, J. D., DiLeone, R. J., Kumar, A., Theobald, D. E., Neve, R. L., and Nestler, E. J. (2006). Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. J. Neurosci. 26, 8235-8242.
12. Han, M. H., Bolanos, C. A., Green, T. A, Olson, V. G., Neve, R. L., Liu, R. J., Aghajanian, G. K., and Nestler, E. J. (2006). Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors. J. Neurosci. 26, 4624-4629.
13. Hyman, S. E., Cole, R. L., Konradi, C., and Kosofsky, B. E. (1995). Dopamine regulation of transcription factor-target interactions in rat striatum. Chem. Senses 20, 257-260.
14. Jancic, D., Lopez de Armentia, M., Valor, L. M., Olivares, R., and Barco, A. (2009). Inhibition of cAMP response element-binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration. Cereb. Cortex. [Epub ahead of print].
15. Kelley, A. E. (2004). Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neurosci. Biobehav. Rev. 27, 765-776.
16. Konradi, C., Cole, R. L., Heckers, S., and Hyman, S. E. (1994). Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J. Neurosci. 14, 5623-5634.
17. Lopez de Armentia, M., Jancic, D., Olivares, R., Alarcon, J. M., Kandel, E. R., and Barco, A. (2007). cAMP response element-binding protein-mediated gene expression increases the intrinsic excitability of CA1 pyramidal neurons. J. Neurosci. 27, 13909-13918.
18. Maldonado, R., Blendy, J. A., Tzavara, E., Gass, P., Roques, B. P., Hanoune, J., and Schutz, G. (1996). Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Science 273, 657-659.
19. Mantamadiotis, T., Lemberger, T., Bleckmann, S. C., Kern, H., Kretz, O., Martin Villalba, A., Tronche, F., Kellendonk, C., Gau, D., Kapfhammer, J., Otto, C., Schmid, W., and Schutz, G. (2002). Disruption of CREB function in brain leads to neurodegeneration. Nat. Genet. 31, 47-54.
20. Mayford, M., Bach, M. E., Huang, Y. Y., Wang, L., Hawkins, R. D., and Kandel, E. R. (1996). Control of memory formation through regulated expression of a CaMKII transgene. Science 274, 1678-1683.
21. Mayr, B., and Montminy, M. (2001). Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2, 599-609.
22. McClung, C. A., and Nestler, E. J. (2003). Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat. Neurosci. 6, 1208-1215.
23. McClung, C. A., and Nestler, E. J. (2008). Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology 33, 3-17.
24. Nestler, E. J. (2004). Molecular mechanisms of drug addiction. Neuropharmacology 47(Suppl. 1), 24-32.
25. Olson, V. G., Zabetian, C. P., Bolanos, C. A., Edwards, S., Barrot, M., Eisch, A. J., Hughes, T., Self, D. W., Neve, R. L., and Nestler, E. J. (2005). Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area. J. Neurosci. 25, 5553-5562.
26. Parkinson, J. A., Olmstead, M. C., Burns, L. H., Robbins, T. W., and Everitt, B. J. (1999). Dissociation in effects of lesions of the nucleus accumbens core and shell on appetitive pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by D-amphetamine. J. Neurosci. 19, 2401-2411.
27. Sanchis-Segura, C., Borchardt, T., Vengeliene, V., Zghoul, T., Bachteler, D., Gass, P., Sprengel, R., and Spanagel, R. (2006). Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. J. Neurosci. 26, 1231-1238.
28. Shaw-Lutchman, TZ, Impey, S., Storm, D., and Nestler, E. J. (2003). Regulation of CRE-mediated transcription in mouse brain by amphetamine. Synapse 48, 10-17.
29. Valverde, O., Mantamadiotis, T., Torrecilla, M., Ugedo, L., Pineda, J., Bleckmann, S., Gass, P., Kretz-O, Mitchell, J. M., Schutz, G., and Maldonado, R. (2004). Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Neuropsychopharmacology 29, 1122-1133.
30. Walters, C. L., Kuo, Y. C., and Blendy, J. A. (2003). Differential distribution of CREB in the mesolimbic dopamine reward pathway. J. Neurochem. 87, 1237-1244.