Plasma levels of folate and vitamin B12 in patients with chronic liver disease;Niveles plasmóticos de la vitamina B12 y ácido fólicoenpacientes con hepatopatía crónica

Gastroenterologia y Hepatologia

Volumn 33, Issue 4, 2010, Pages 280-287

  Muro, Nerea ^a   Bujanda, Luis ^a   Sarasqueta, Cristina ^b   Gil, Inés ^a   Hijona, Elizabeth ^a   Cosme, Ángel ^a   Arenas Jr , Juan ^a   Elosegui, María E ^b   Sarasola, Miren ^b   Calpasoro, José ^b   Arenas, Juan I ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b HOSPITAL DONOSTIA   (Spain)

Author keywords

Alcoholism; Etiology; Folate; Liver disease; Vitamin B12

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYANOCOBALAMIN; FOLIC ACID; GAMMA GLUTAMYLTRANSFERASE; HOMOCYSTEINE;

ADULT; ALCOHOL LIVER CIRRHOSIS; ARTICLE; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DECOMPENSATED LIVER CIRRHOSIS; DIFFERENTIAL DIAGNOSIS; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; MALE; MEAN CORPUSCULAR VOLUME; NUTRITIONAL STATUS; PROGNOSIS; SENSITIVITY AND SPECIFICITY; VITAMIN BLOOD LEVEL; ADOLESCENT; AGED; ALCOHOL LIVER DISEASE; BLOOD; FOLIC ACID DEFICIENCY; LIVER CIRRHOSIS; LIVER FAILURE; LIVER FUNCTION TEST; METHODOLOGY; MIDDLE AGED; PROSPECTIVE STUDY;

ADOLESCENT; ADULT; AGED; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; DIAGNOSIS, DIFFERENTIAL; ERYTHROCYTE INDICES; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; GAMMA-GLUTAMYLTRANSFERASE; HOMOCYSTEINE; HUMANS; LIVER CIRRHOSIS; LIVER CIRRHOSIS, ALCOHOLIC; LIVER DISEASES, ALCOHOLIC; LIVER FAILURE; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; VITAMIN B 12; YOUNG ADULT;

EID: 77952886030     PISSN: 02105705     EISSN: 15789519     Source Type: Journal    
DOI: 10.1016/j.gastrohep.2009.12.001     Document Type: Article

References (31)

1. Davern T.J., Scharschmidt B.F. Biochemical liver test. Sleisenger & Fordtran's gastrointestinal and livr disease: pathophysiology, diagnosis and management 2002, 1227-1237. Sanders, Philadelphia, Penssylvania. 7th ed. M. Feldman, L.S. Friedman, M.H. Sleisenger (Eds.).
2. National Institute on alcohol abuse and alcoholism. Alcohol Alert 19; alcohol and the liver. PH 329. Rockville, MD: the Institute, 1993.
3. DeBakey S.F., Stinson F.S., Grant B.F., Dufour M.C. Surveillance Report #41. Liver Cirrhosis Mortality in the United States, 1970-93 1996, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD.
4. Marsano L.S., Mendez C., Hill D., Barve S., Mc Clain C.J. Diagnosis and treatment of alcoholic liver disease and its complications. Alcohol Res Health 2003, 27:247-256.
5. Conigrave K.M., Degenhardt L.J., Whitfield J.B., Saunders J.B., Helander A., Tabakoff B. CDT, GGT, and AST As Markers of Alcohol Use: The WHO/ISBRA Collaborative Project. Alcoholim Clin Exp Res 2002, 26:332-339. WHO/ISBRA Study Group.
6. Lieber C.S. Relationships between nutrition, alcohol use, and liver disease. Alcohol Res Health 2003, 27:220-231.
7. Wu L.L., Wu J.T. Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin Chim Acta 2002, 322:21-28.
8. Alberino F., Gatta A., Amodio P., Merkel C., Pascoli L.D., Boffo G., et al. Nutrition and survival in patients with liver cirrhosis. Nutrition 2001, 17:445-450.
9. Gloria L., Cravo M., Camilo M.E., Resende M., Cardoso J.N., Oliveira A.G., et al. Nutritional deficiencies in chronic alcoholics: relation to dietary intake and alcohol consumption. Am J Gastroenterol 1997, 92:485-489.
10. Merli M., Riggio O. Does malnutrition affect survival in cirrhosis?. Hepatology 1996, 23:1041-1046. Dally, PINC (Policentrica Italiana Nutrizione Cirrosi).
11. Cravo M.L., Gloria L.M., Selhub J., Nadean M.R., Camilo M.E., Resende M.P., et al. Hyperhomocysteinemiainchronic alcoholism: correlation with folate, vitamin B-12, anda vitamin B-6 status. Am J Clin Nutr 1996, 63:220-224.
12. Halifeoglu I., Gur B. Plasma trace elements, vitamin B12, folate, and homocysteine levels in cirrhotic patients compared to healthy controls. Biochemistry 2004, 69:693-696.
13. Savage D., Lidenbaum J. Anemia in alcoholics. Medicine 1986, 65:322-338.
14. Blasco C., Caballería J., Deulofeu R., Lligoña A., Parés A., Lluis J.M., et al. Prevalence and mechanisms of hyperhomocysteinemia in chronic alcoholics. Alcoholis Clin Exp Res 2005, 29:1044-1048.
15. Purohit V., Abdelmalek M.F., Barve S., Benevenga N.J., Halsted C.H., Kaplowitz N., et al. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr 2007, 86:14-24.
16. Herbert V., Zaluski R., Davidson C.S. Correlation of folate deficiency with alcoholism and associated macrocytosis, anemia and liver disease. Ann Intern Med 1963, 58:977-988.
17. Klipstein F.A., Lindenbaum J. Folate deficiency in chronic liver disease. Blood 1965, 25:443-456.
18. Kazimierska E., Czestochowska E. Serum homocysteine, vitamin B12 and folic acid concentrations in patients with alcoholic liver cirrhosis. Pol Merkuriusz Lek 2003, 15:140-143.
19. Majumdar S.K., Shaw G.K., O'Gorman P., Aps E.J., Offerman E.L., Thomson A.D. Blood vitamin status (B1, B2, B6, folic acid and B12) in patients with alcoholic liver disease. Int J Vitam Nutr Res 1982, 52:266-271.
20. Ermens A.A., Vlasveld L.T., Lindemans J. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem 2003, 36:585-590.
21. Lambert D., Benhayoun S., Adajalla C. Alcoholic cirrhosis and cobalamin metabolism. Digestion 1997, 58:64-71.
22. Kanazawa S., Herbert V. Total corrinoid, cobalamin and cobalamin analogue levels may be normal in serum despite cobalamin in liver depletion in patients with alcoholism. Lab Invest 1985, 53:108-110.
23. De La Vega M.J., Santolaria F., Gonzalez-Reimers E., Alemán M.R., Milena A., Martínez-Riera A., et al. High prevalence of hyperhomocysteinemia in chronic alcoholism: the importance of the thermolabile form of the enzyme methylenetetrahydrofolate reductase (MTHFR). Alcohol 2001, 25:59-67.
24. Hultberg B., Berglund M., Andersson A., Frank A. Elevated plasma homocysteine in alcoholics. Alcohol Clin Exp Res 1993, 17:687-689.
25. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002; 288: 2015-2.
26. Halsted C.H., Villanueva J.A., Devlin A.M., Niemelä O., Parkkila S., Garrow T.A., et al. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl AcadSci U S A 2002, 99:10072-10077.
27. Halsted C.H., Villanueva J.A., Devlin A.M. Folate deficiency, methionine metabolism, and alcoholic liver disease. Alcohol 2002, 27:169-172.
28. Djalali M., Champigneulle B., Gueant J.L. Increased serum corrinoids correlates with disease severity and Ig A levels in alcoholic cirrhosis. Digestion 1988, 4:215-222.
29. Schernhammer E., Wolpin B., Rifai N., Cochrane B., Manson J.A., Ma J., et al. Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. Cancer Res 2007, 67:5553-5560.
30. Yang Q., Bostick R.M., Friedman J.M., Flanders W.D. Serum folate and cancer mortality among US adults: findings from the third National Health and Nutritional Examination Survey linked mortality file. Cancer Epidemiol Biomarkers Prev 2009, 18:1439-1447.
31. Galván-Portillo M.V., Oñate-Ocaña L.F., Pérez-Pérez G.I., Chen J., Herrera-Goepfert R., Chichu-Amparan L., et al. Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers. Nutrition 2010; 26:201-8, doi:10.1016/j.nut.2009.05.006.