Inhibition of the expression and function of TRPV4 by RNA interference in dorsal root ganglion

Neurological Research

Volumn 32, Issue 5, 2010, Pages 466-471

  Liu, Ting Ting ^a,b   Bi, Hong Sheng ^b   Lv, Shan Yun ^c   Wang, Xing Rong ^b   Yue, Shou Wei ^a  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Traditional Chinese Medicine University   (China)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Calcium channels; Dorsal root ganglion; Pain; SiRNA; TRPV4

Indexed keywords

CALCIUM; MESSENGER RNA; PROTEIN KINASE C; SMALL INTERFERING RNA; SUBSTANCE P; VANILLOID RECEPTOR 4; RNA; VANILLOID RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SPINAL GANGLION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; GENETIC TRANSFECTION; METABOLISM; NERVE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; NEURONS; PROTEIN KINASE C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA INTERFERENCE; RNA, MESSENGER; SUBSTANCE P; TRANSFECTION; TRPV CATION CHANNELS;

EID: 77952853224     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/174313209X408945     Document Type: Article

References (28)

1. Tominaga M, Tominaga T. Structure and function of TRPV1. Pflugers Arch 2005; 451 (1): 143-150
2. Priestley T, Hunter JC. Voltage-gated sodium channels as molecular targets for neuropathic pain. Drug Dev Res 2006; 67 (4): 360-375
3. Dong XW, Goregoaker S, Engler H, et al. Small interfering RNAmediated selective knock down of NaV1.8 tetrodotoxin-resistant sodium channel reverses mechanical allodynia in neuropathic rats. Neuroscience 2007; 146 (2): 812-821
4. Christoph T, Grunweller A, Mika J, et al. Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. Biochem Biophys Res Commun 2006; 350 (1): 238-243
5. Alessandri-Haber N, Joseph E, Dina OA, et al. TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain 2005; 118 (1-2): 70-79
6. Liedtke W, Choe Y, Marti-Renom MA, et al. Vanilloid receptorrelated osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 2000; 103 (3): 525-535
7. Guler AD, Lee H, Iida T, et al. Heat-evoked activation of the ion channel, TRPV4. J Neurosci 2002; 22: 6408-6414
8. Becker D, Blase C, Bereiter-Hahn J, et al. TRPV4 exhibits a functional role in cell-volume regulation. J Cell Sci 2005; 118 (Pt 11): 2435-2440
9. Grant AD, Cottrell GS, Amadesi S, et al. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol 2007; 578 (Pt 3): 715-733
10. Alessandri-Haber N, Dina OA, Yeh JJ, et al. Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J Neurosci 2004; 24 (18): 4444-4452
11. Zhang Y, Wang YH, Zhang XH, et al. Proteomic analysis of differential proteins related to the neuropathic pain and neuroprotection in the dorsal root ganglion following its chronic compression in rats. Exp Brain Res 2008; 189 (2): 199-209
12. Zhang Y, Wang YH, Ge HY, et al. A transient receptor potential vanilloid 4 contributes to mechanical allodynia following chronic compression of dorsal root ganglion in rats. Neurosci Lett 2008; 432 (3): 222-227
13. Vellani V, Mapplebeck S, Moriondo A, et al. Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol 2001; 534 (Pt 3): 813-825
14. Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21- nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411 (6836): 494-498
15. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29 (9): e45
16. Vellani V, Zachrisson O, McNaughton PA. Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF. J Physiol 2004; 560 (Pt 2): 391-401
17. Schaap D, Parker PJ, Bristol A, et al. Unique substrate specificity and regulatory properties of PKC-epsilon: A rationale for diversity. FEBS Lett 1989; 243 (2): 351-357
18. Liedtke W, Friedman JM. Abnormal osmotic regulation in trpv42/2 mice. Proc Natl Acad Sci USA 2003; 100 (23): 13698-13703
19. Liedtke W. TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. J Physiol 2005; 567 (Pt 1): 53-58
20. Krichevsky AM, Kosik KS. RNAi functions in cultured mammalian neurons. Proc Natl Acad Sci USA 2002; 99 (18): 11926-11929
21. Anesti AM, Peeters PJ, Royaux I, et al. Efficient delivery of RNA interference to peripheral neurons in vivo using herpes simplex virus. Nucleic Acids Res 2008; 36 (14): e86
22. Marrelli SP, O'Neil RG, Brown RC, et al. PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries. Am J Physiol Heart Circ Physiol 2007; 292 (3): H1390-H1397
23. Marrelli SP. TRPV4 channels contribute to ATP-stimulated calcium influx in endothelial cells. FASEB J 2008; 22: 964.31
24. Yang XD, Liu Z, Liu HX, et al. Regulatory effect of nerve growth factor on release of substance P in cultured dorsal root ganglion neurons of rat. Neurosci Bull 2007; 23 (4): 215-220
25. Garcia-Elias A, Lorenzo IM, Vicente R, et al. IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulinbinding site. J Biol Chem 2008; 283 (46): 31284-31288
26. Wu L, Gao X, Brown RC, et al. Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells. Am J Physiol Renal Physiol 2007; 293 (5): F1699-F1713
27. Gaudet R. TRP channels entering the structural era. J Physiol 2008; 586 (Pt 15): 3565-3575
28. Arniges M, Fernandez-Fernandez JM, Albrecht N, et al. Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem 2006; 281 (3): 1580-1586