Psychological considerations of the child with asthma

Child and Adolescent Psychiatric Clinics of North America

Volumn 19, Issue 2, 2010, Pages 319-333

  Peters, Todd E ^a   Fritz, Gregory K ^a,b,c  

^a BROWN UNIVERSITY   (United States)

^b E P BRADLEY HOSPITAL   (United States)

^c HASBRO CHILDREN'S HOSPITAL   (United States)

Author keywords

Anxiety; Asthma; Children; Depression; Review

Indexed keywords

BECLOMETASONE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; CROMOGLYCATE DISODIUM; FLUTICASONE; FORMOTEROL; LEUKOTRIENE RECEPTOR STIMULATING AGENT; LEVALBUTEROL; MOMETASONE FUROATE; NEDOCROMIL; PIRBUTEROL; SALBUTAMOL; SALMETEROL; THEOPHYLLINE; TRIAMCINOLONE;

ANXIETY DISORDER; ASTHMA; BEHAVIOR DISORDER; CAUSAL ATTRIBUTION; DEPRESSION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; HEALTH EDUCATION; HIGH RISK BEHAVIOR; HUMAN; HYPERVENTILATION; LOW DRUG DOSE; MENTAL DISEASE; PRIORITY JOURNAL; PROGRAM DEVELOPMENT; PSYCHOEDUCATION; REVIEW; SCHOOL; TREATMENT INDICATION;

ADOLESCENT; ANTI-INFLAMMATORY AGENTS; ANXIETY DISORDERS; ASTHMA; BIOFEEDBACK, PSYCHOLOGY; BRONCHODILATOR AGENTS; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; DEPRESSIVE DISORDER; DYSPNEA; ENVIRONMENTAL EXPOSURE; HUMANS; OVERDOSE; PEAK EXPIRATORY FLOW RATE; RELAXATION;

EID: 77952852167     PISSN: 10564993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chc.2010.01.006     Document Type: Review

References (100)

1. Moorman J., Rudd R.A., Johnson C.A., et al. National surveillance for asthma - United States, 1980-2004. MMWR Surveill Summ 2007, 56(SS08):1-14. 18-54.
2. Busse W.W., Lemanske R.F. Asthma. N Engl J Med 2001, 344(5):350-362.
3. Weinberger M., Abu-Hasan M. Pseudo-asthma: when cough, wheezing, and dyspnea are not asthma. Pediatrics 2007, 120(4):855-864.
4. Weinberger M., Abu-Hasan M. Perceptions and pathophysiology of dyspnea and exercise tolerance. Pediatr Clin North Am 2009, 56(1):33-48.
5. McQuaid E.L., Spieth L.E., Spirito A. The pediatric psychologist's role in differential diagnosis: vocal-cord dysfunction presenting as asthma. J Pediatr Psychol 1997, 22(5):739-748.
6. Lai C.K., Beasley R., Crane J., et al. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009, 64(6):476-483.
7. National Health Interview Survey, National Center for Health Statistics, CDC Centers for Disease Control and Prevention website. Table 1-1 and 2-1 2008, Available at:, Accessed December 1, 2009. http://www.cdc.gov/asthma/nhis/06/data.htm.
8. Akinbami L.J., Schoendorf K.C. Trends in childhood asthma: prevalence, health care utilization, and mortality. Pediatrics 2002, 110(2):315-322.
9. Canino G., Koinis-Mitchell D., Ortega A.N., et al. Asthma disparities in the prevalence, morbidity, and treatment of Latino children. Soc Sci Med 2006, 63(11):2926-2937.
10. Bahadori K., Doyle-Waters M.M., Marra C., et al. Economic burden of asthma: a systematic review. BMC Pulm Med 2009, 19:9-24.
11. Alexander F. Psychosomatic medicine: its principles and application 1950, W.W. Norton & Co, New York.
12. Kozyrskyj A.L., Mustard C.A., Simons F.E.R. Socioeconomic status, drug insurance benefits, and new prescriptions for inhaled corticosteroids in schoolchildren with asthma. Arch Pediatr Adolesc Med 2001, 155(11):1219-1224.
13. Kozyrskyj A.L., Mai X., McGrath P., et al. Continued exposure to maternal distress in early life is associated with an increased risk of childhood asthma. Am J Respir Crit Care Med 2008, 177(2):142-147.
14. Cookson H., Granell R., Joinson C., et al. Mothers' anxiety during pregnancy is associated with asthma in their children. J Allergy Clin Immunol 2009, 123(4):847-853.
15. Shalowitz M.U., Berry C.A., Quinn K.A., et al. The relationship of life stressors and maternal depression to pediatric asthma morbidity in a subspecialty practice. Ambul Pediatr 2001, 1(4):185-193.
16. Bartlett S.J., Kolodner K., Butz A.M., et al. Maternal depressive symptoms and emergency department use among inner-city children with asthma. Arch Pediatr Adolesc Med 2001, 155:347-353.
17. Weil C.M., Wade S.L., Bauman L.J., et al. The relationship between psychosocial factors and asthma morbidity in inner-city children with asthma. Pediatrics 1999, 104(6):1274-1280.
18. Brown E.S., Gan V., Jeffress J., et al. Psychiatric symptomatology and disorders in caregivers of children with asthma. Pediatrics 2006, 118(6):e1715-e1720.
19. Chen E., Schreier H.M.C. Does the social environment contribute to asthma?. Immunol Allergy Clin North Am 2008, 28:649-664.
20. Wright R.J., Cohen S., Carey V., et al. Parental stress as a predictor of wheezing in infancy: a prospective birth-cohort study. Am J Respir Crit Care Med 2002, 165(3):358-365.
21. Klinnert M.D., Nelson H.S., Price M.R., et al. Onset and persistence of childhood asthma: predictors from infancy. Pediatrics 2001, 108(4):e69.
22. Klinnert M.D., Mrazek P.J., Mrazek D.A. Early asthma onset: the interaction between family stressors and adaptive parenting. Psychiatry 1994, 57(1):51-61.
23. McQuaid E.L., Kopel S.J., Nassau J.H. Behavioral adjustment in children with asthma: a meta-analysis. J Dev Behav Pediatr 2001, 22(6):430-439.
24. Wamboldt M.Z., Fritz G., Mansell A., et al. Relationship of asthma severity and psychological problems in children. J Am Acad Child Adolesc Psychiatry 1998, 37(9):943-950.
25. Kashani J.H., König P., Shepperd J.A., et al. Psychopathology and self-concept in asthmatic children. J Pediatr Psychol 1998, 13(4):509-520.
26. Katon W.J., Richardson L., Lozano P., et al. The relationship of asthma and anxiety disorders. Psychosom Med 2004, 66(3):349-355.
27. Bussing R., Burket R.C., Kelleher E.T. Prevalence of anxiety disorders in a clinic-based sample of pediatric asthma patients. Psychosomatics 1996, 37(2):108-115.
28. Vila G., Nollet-Clemençon C., Vera M., et al. Prevalence of DSM-IV disorders in children and adolescents with asthma versus diabetes. Can J Psychiatry 1999, 44(6):562-569.
29. Vila G., Nollet-Clemençon C., de Blic J., et al. Prevalence of DSM IV anxiety and affective disorders in a pediatric population of asthmatic children and adolescents. J Affect Disord 2000, 58(3):223-231.
30. Craske M.G., Poulton R., Tsao J.C.I., et al. Paths to panic disorder/agoraphobia: an exploratory analysis from age 3 to 21 in an unselected birth cohort. J Am Acad Child Adolesc Psychiatry 2001, 40(5):556-563.
31. Ortega A.N., Huertas S.E., Canino G., et al. Childhood asthma, chronic illness, and psychiatric disorders. J Nerv Ment Dis 2002, 190(5):275-281.
32. Goodwin R.D., Pine D.S., Hoven C.W. Asthma and panic attacks among youth in the community. J Asthma 2003, 40(2):139-145.
33. Ortega A.N., McQuaid E.L., Canino G., et al. Association of psychiatric disorders and different indicators of asthma in island Puerto Rican children. Soc Psychiatry Psychiatr Epidemiol 2003, 38(4):220-226.
34. Feldman J.M., Ortega A.N., McQuaid E.L., et al. Comorbidity between asthma attacks and internalizing disorders among Puerto Rican children at one-year follow-up. Psychosomatics 2006, 47(4):333-339.
35. Kean E.M., Kelsay K., Wamboldt F., et al. Posttraumatic stress in adolescents with asthma and their parents. J Am Acad Child Adolesc Psychiatry 2006, 45(1):78-86.
36. Ortega A.N., McQuaid E.L., Canino G., et al. Comorbidity of asthma and anxiety and depression in Puerto Rican children. Psychosomatics 2004, 45(2):93-99.
37. Bruzzese J., Fisher P.H., Lemp N., et al. Asthma and social anxiety in adolescents. J Pediatr 2009, 155(3):398-403.
38. Katon W., Lozano P., Russo J., et al. The prevalence of DSM-IV anxiety and depressive disorders in youth with asthma compared to controls. J Adolesc Health 2007, 41(5):455-463.
39. Blackman J.A., Gurka M.J. Developmental and behavioral comorbidities of asthma in children. J Dev Behav Pediatr 2007, 28(2):92-99.
40. van Dyck P., Kogan M.D., Heppel D., et al. The National Survey of Children's Health: a new data resource. Matern Child Health J 2004, 8(3):183-188.
41. Bender B. Risk taking, depression, adherence, and symptom control in adolescents and young adults with asthma. Am J Respir Crit Care Med 2006, 173(9):953-957.
42. Eaton D.K., Kann L., Kinchen S. Youth risk behavior surveillance - United States, 2005. MMWR Surveill Summ 2006, 55(5):1-108.
43. Bender B.G. Depression symptoms and substance abuse in adolescents with asthma. Ann Allergy Asthma Immunol 2007, 99(4):319-324.
44. Bush T., Richardson L., Katon W., et al. Anxiety and depressive disorders are associated with smoking in adolescents with asthma. J Adolesc Health 2007, 40(5):425-432.
45. Waxmonsky J., Wood B.L., Stern T., et al. Association of depressive symptoms and disease activity in children with asthma: methodological and clinical implications. J Am Acad Child Adolesc Psychiatry 2006, 45(8):945-954.
46. Richardson L.P., Lozano P., Russo J., et al. Asthma symptom burden: relationship to asthma severity and anxiety and depression symptoms. Pediatrics 2006, 118(3):1042-1051.
47. Bender B., Zhang L. Negative affect, medication adherence, and asthma control in children. J Allergy Clin Immunol 2008, 122(3):490-495.
48. Isenberg S.A., Lehrer P.M., Hochron S. The effects of suggestion and emotional arousal on pulmonary function in asthma: a review and hypothesis regarding vagal mediation. Psychosom Med 1992, 54(2):192-216.
49. Wright R.J., Rodriguez M., Cohen S. Review of psychosocial stress and asthma: an integrated biopsychosocial approach. Thorax 1998, 53(12):1066-1074.
50. Miller B.D., Wood B.L. Influence of specific emotional states on autonomic reactivity and pulmonary function in asthmatic children. J Am Acad Child Adolesc Psychiatry 1997, 36(5):669-677.
51. McQuaid E.L., Fritz G.K., Nassau J.H., et al. Stress and airway resistance in children with asthma. J Psychosom Res 2000, 49(4):239-245.
52. Sandberg S., Järvenpää S., Penttinen A., et al. Asthma exacerbations in children immediately following stressful life events: a Cox's hierarchical regression. Thorax 2004, 59(12):1046-1051.
53. Wright R.J. Stress and atopic disorders. J Allergy Clin Immunol 2005, 116(6):1301-1306.
54. Wright R.J., Cohen C.T., Cohen S. The impact of stress on the development and expression of atopy. Curr Opin Allergy Clin Immunol 2005, 5(1):23-29.
55. Chen E., Miller G.E. Stress and inflammation in exacerbations of asthma. Brain Behav Immun 2007, 21(8):993-999.
56. Robinson D., Hamid Q., Bentley A., et al. Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993, 92(2):313-324.
57. Boniface S., Koscher V., Mamessier E., et al. Assessment of T lymphocyte cytokine production in induced sputum from asthmatics: a flow cytometry study. Clin Exp Allergy 2003, 33(9):1238-1243.
58. Macaubas C., de Klerk N.H., Holt B.J., et al. Association between antenatal cytokine production in the development of atopy and asthma at age 6 years. Lancet 2003, 362(9391):1192-1197.
59. Neaville W.A., Tisler B.S., Bhattacharya A., et al. Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life. J Allergy Clin Immunol 2003, 112(4):740-746.
60. Prescott S.L., King B., Strong T.L., et al. The value of perinatal immune responses in predicting allergic disease at 6 years of age. Allergy 2003, 58(11):1187-1194.
61. Cho S., Stanciu L.A., Holgate S.T., et al. Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma. Am J Respir Crit Care Med 2005, 171(3):224-230.
62. Ngoc P.L., Gold D.R., Tzianabos A.O., et al. Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol 2005, 5(2):161-166.
63. Nassau J.H., Tien K., Fritz G.K. Review of the literature: integrating psychoneuroimmunology into pediatric chronic illness interventions. J Pediatr Psychol 2008, 33(2):195-207.
64. National Asthma Education and Prevention Program Expert Panel Report 3. Summary Report 2007-guidelines for the diagnosis and management of asthma NIH Publication Number 08-5846. Available at:, Accessed December 1, 2009. http://www.nhlbi.nih.gov/guidelines/asthma/asthsumm.pdf.
65. Fanta C.H. Asthma. N Engl J Med 2009, 360(10):1002-1014.
66. Milgrom H., Bender B., Ackerson L., et al. Clinical aspects of allergic disease. J Allergy Clin Immunol 1996, 98(6 Pt 1):1051-1057.
67. Bender B., Milgrom H., Rand C., et al. Psychological factors associated with medication nonadherence in asthmatic children. J Asthma 1998, 35(4):347-353.
68. Celano M., Geller R.J., Phillips K.M., et al. Treatment adherence among low-income children with asthma. J Pediatr Psychol 1998, 23(6):345-349.
69. Bender B., Wamboldt F.S., O'Connor S.L., et al. Measurement of children's asthma medication adherence by self report, mother report, canister weight, and Doser CT. Ann Allergy Asthma Immunol 2000, 85(5):416-421.
70. McQuaid E.L., Kopel S.J., Klein R.B., et al. Medication adherence in pediatric asthma: reasoning, responsibility, and behavior. J Pediatr Psychol 2003, 28(5):323-333.
71. McQuaid E.L., Howard K., Kopel S.J., et al. Developmental concepts of asthma: reasoning about illness and strategies for prevention. J Appl Dev Psychol 2002, 23(2):179-194.
72. Katon W.J., Richardson L., Russo J., et al. Quality of mental health care for youth with asthma and comorbid anxiety and depression. Med Care 2006, 44(12):1064-1072.
73. Rockhill C.M., Russo J.E., McCauley E., et al. Agreement between parents and children regarding anxiety and depression diagnoses in children with asthma. J Nerv Ment Dis 2007, 195(11):897-904.
74. Richardson L.P., Russo J.E., Lozano P., et al. The effect of comorbid anxiety and depressive disorders on health care utilization and costs among adolescents with asthma. Gen Hosp Psychiatry 2008, 30(5):398-406.
75. Fritz G.K., McQuaid E.L., Spirito A., et al. Symptom perception in pediatric asthma: relationship to functional morbidity and psychological factors. J Am Acad Child Adolesc Psychiatry 1996, 35(8):1033-1041.
76. Kikuchi Y., Okabe S., Tamura G. Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma. N Engl J Med 1994, 330(19):1329-1334.
77. Kifle Y., Seng V., Davenport P.W. Magnitude estimation of inspiratory resistive loads in children with life-threatening asthma. Am J Respir Crit Care Med 1997, 156(5):1530-1535.
78. Fritz G.K., Adams S.K., McQuaid E.L., et al. Symptom perception in pediatric asthma. Chest 2007, 132(3):884-889.
79. Feldman J.M., McQuaid E.L., Klein R.B., et al. Symptom perception and functional morbidity across a 1-year follow-up in pediatric asthma. Pediatr Pulmonol 2007, 42:339-347.
80. Koinis-Mitchell D., McQuaid E.L., Seifer R., et al. Symptom perception in children with asthma: cognitive and psychological factors. Health Psychol 2009, 28(2):226-237.
81. McQuaid E.L., Nassau J.H. Empirically supported treatments of disease-related symptoms in pediatric psychology: asthma, diabetes, and cancer. J Pediatr Psychol 1999, 24(4):305-328.
82. Alexander A.B. Systematic relaxation and flow rates in asthmatic children: relationship to emotional precipitants and anxiety. J Psychosom Res 1972, 16(6):405-410.
83. Alexander A.B., Miklich D.R., Hershkoff H. The immediate effects of systematic relaxation training on peak expiratory flow rates in asthmatic children. Psychosom Med 1972, 34(5):388-394.
84. Miklich D.R., Renne C.M., Creer T.L., et al. The clinical utility of behavior therapy as an adjunctive treatment for asthma. J Allergy Clin Immunol 1977, 60(5):285-294.
85. Vazquez M.I., Buceta J.M. Effectiveness of self-management programmes and relaxation training in the treatment of bronchial asthma: relationships with trait anxiety and emotional attack triggers. J Psychosom Res 1993, 37(1):71-81.
86. Vazquez M.I., Buceta J.M. Psychological treatment of asthma: effectiveness of a self-management program with and without relaxation training. J Asthma 1993, 30(3):171-183.
87. Vázquez I., Buceta J. Relaxation therapy in the treatment of bronchial asthma: effects on basal spirometric values. Psychother Psychosom 1993, 60(2):106-112.
88. King N.J. The behavioral management of asthma and asthma-related problems in children: a critical review of the literature. J Behav Med 1980, 3(2):169-189.
89. Davis M.H., Saunders D.R., Creer T.L., et al. Relaxation training facilitated by biofeedback apparatus as a supplemental treatment in bronchial asthma. J Psychosom Res 1973, 17(2):121-128.
90. Scherr M.S., Crawford P.L., Sergent C.B., et al. Effect of bio-feedback techniques on chronic asthma in a summer camp environment. Ann Allergy 1975, 35(5):289-295.
91. Kotses H., Harver A., Segreto J., et al. Long-term effects of biofeedback-induced facial relaxation on measures of asthma severity in children. Biofeedback Self Regul 1991, 16(1):1-21.
92. Glaus K.D., Kotses H. Facial muscle tension influences lung airway resistance; limb muscle tension does not. Biol Psychol 1983, 17(2-3):105-120.
93. Kotses H., Glaus K.D., Bricel S.K., et al. Operant muscular relaxation and peak expiratory flow rate in asthmatic children. J Psychosom Res 1978, 22(1):17-23.
94. Kotses H., Glaus K.D., Crawford P.L., et al. Operant reduction of frontalis EMB activity in the treatment of asthma in children. J Psychosom Res 1976, 20(5):453-459.
95. Feldman G.M. The effect of biofeedback training on respiratory resistance of asthmatic children. Psychosom Med 1976, 38(1):27-34.
96. Guevara J.P., Wolf F.M., Grum C.M., et al. Effects of educational interventions for self management of asthma in children and adolescents: systematic review and meta-analysis. BMJ 2003, 326(7402):1308-1309.
97. DePue J.D., McQuaid E.L., Koinis-Mitchell D., et al. Providence School Asthma Partnership: school-based asthma program for inner-city families. J Asthma 2007, 44(6):449-453.
98. McCauley E., Katon W., Russo J., et al. Impact of anxiety and depression on functional impairment in adolescents with asthma. Gen Hosp Psychiatry 2007, 29(3):214-222.
99. Vila G., Nollet-Clémençon C., de Blic J., et al. Assessment of anxiety disorders in asthmatic children. Psychosomatics 1999, 40(5):404-413.
100. Gupta S., Crawford S.G., Mitchell I. Screening children with asthma for psychosocial adjustment problems: a tool for health care professionals. J Asthma 2006, 43(7):543-548.