The importance of CagA protein in Helicobacter pylori infection;Importancia de la proteína CagA en infección por Helicobacter pylori

Revista Colombiana de Gastroenterologia

Volumn 24, Issue 4, 2009, Pages 388-395

  Arévalo, Azucena ^a   Trespalacios, Alba Alicia ^a   Otero, William ^b  

^a PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

^b UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

Caga; Helicobacter pylori; Pathogenicity island

Indexed keywords

EID: 77952836183     PISSN: 01209957     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Amieva Manuel R, Elomar E. Host Bacterial Interactions in Helicobacter pylori Infection. Gastroenterology 2008; 134: 306-329.
2. Michael Hocker, Peter Hohenberger. Helicobacter pylori virulence factors-one part of a big picture. Lancet 2003; 362: 1231-33.
3. Osamu Handa, Yuji Naito, Toshikazu Yoshikawa. CagA protein of Helicobacter pylori: A hijacker of epithelial cell signaling. Biochemical pharmacology 2007; 73: 1697-1702
4. Mobley Harry LT, Mendz George L, Hazell Stuart L. Helicobacter pylori. Physiology and Genetics. Chapter 31. The cagPathogenecy Island 2001. p. 608
5. C Audibert, C Burucoa, B Janvier, JL Fauchere. Implication of the Structure of the Helicobacter pylori cag Pathogenicity Island in Induction of Interleukin-8 Secretion. Infection and Immunity 2000; 1625-1629.
6. Jorg Harcker, James B. Kaper. Pathogenicity Islands and the Evolution of Microbes. Annual Review of Microbiology 2000; 54: 641-679.
7. Stefano Censini, Christina Lange, Zhaoying Xiang, Jean E Crabtree, Paolo Ghiara, Mark Borodovsky. cag, a pathogenicity island of Helicobacter pylori, encodes typeI-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 1996; 93: 14648-14653.
8. Tummuru MK, Cover TL, Blaser MJ. Cloning and expression of a high-molecular-mass major antigen of helicobacter pylori: evidence of linkage to cytotoxin production. Infection and Immunity 1994; 61: 1809ArmelleMenard, Antoine Danchin, Sandrine Dupouy, Francis Megraud, Philippe Lehours. A Variable Gene in a Conserved Region of the Helicobacter pylori Genome: Isotopic Gene Replacement or Rapid Evolution? Dna Research 2008; 15: 163-8.
9. NS Akopyants, SW Clifton, D Kersulyte, JE Crabtree, BE Youree, CA Reece, et al. Analysis of the cag pathogenicity island of Helicobacter pylori. Molecular Microbiology 1998; 28: 37-53
10. Mohaboob A, Aleem A Khan, Santosh K Tiwari, Niyaz Ahmed, L Venkateswar Rao, CM Habibullah. Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer, gastric carcinoma, and non-ulcer dyspepsia subjects with histological changes. Gastroenterol 2005; 11: 6815-6822.
11. Tomb, J.F, Owen White, Anthony R. Kerlavage, Rebecca A. Clayton, Granger G. Sutton, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997; 388: 539-547.
12. Stefan Kutter, Renate Buhrdorf, Jurgen Haas, Wulf Schneider-Brachert, Rainer Haas, Wolfgang Fischer. Protein Subassemblies of the Helicobacter pylori Cag Type IV Secretion System Revealed by Localization and Interaction Studies. Journal of Bacteriology 2008; 190: 2161-2171.
13. Valerie J Busler, Victor J Torres, Mark S McClain, Oscar Tirado, David B Friedman, Timothy L. Cover. Protein-Protein Interactions among Helicobacter pylori Cag Proteins. Journal of Bacteriology 2006; 188: 4787-4800.
14. Steffen Backert, Matthias Selbach. Role of type IV secretion in Helicobacter pylori pathogenesis. Cellular Microbiology 2008; 10: 1573-1581.
15. Zhong Qiao, Shao Shi-He, Cui Lei-Lei, Mu Run-Hong, Ju Xiao-Li and Dong Su-Rong. Type IV secretion system in Helicobacter pylori: a new insight into pathogenicity. Clin Med J 2007; 120: 2138-2142.
16. Leen-Jan Van Doorn, Ceu Figueiredo, Ricardo Sanna, Anton Plaisier, Peter Schneeberger, Wink de Boer, et al. Clinical Relevance of the cagA, vacA, and iceA Status of Helicobacter pylori. Gastroenterology 1998; 115: 58-56.
17. Yoshico Yamaoka, Mototsugu Kato, Masahiro Asaka. Geographic Diff erences in Gastric Cancer Incidence Can be explained by diff erences between Helicobacter pylori Strains. Internal Medicine 2008; 47: 1077-1083.
18. Yuri Churin, Laila Al-Ghoul, Oliver Kepp, Thomas F. Meyer, Walter Birchmeier, and Michael Naumann. Helicobacter pylori CagA protein targets the c.Met receptor and enhances the motogenic response. The Journal of Cell Biology 2003; 161: 249-255.
19. Masanori Hatakeyama. Oncogenic Mechanisms of the Helicobacter pylori CagA protein. Nature Reviews Cancer 2004; 4: 688-694.
20. Y Yamaoka, O Ojo, S Fujimoto, S Odenbreit, R Haas, O Gutierrez, H M, T El-Zimaity. Helicobacter pylori outer membrane proteins and gastroduodenal disease. Gut 2006; 55: 775-781.
21. Naomi Ohnishi, Hitomi Yuasa, Shinya Tanaka, Hirofumi Sawa, Motohiro Miura, Atsushi Matsu, et al. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. PNAS 2008; 105: 1003-1008.
22. Chin Ho Lai, Yun-Chieh Chang, Shin-Yi Du, Hung-Jung Wang, Chun-Hsien Kuo, Shih-Hua Fang, et al. Cholesterol Depletion Reduces Helicobacter pylori CagA translocation and CagA-Induced Responses in AGS Cells. Infection and Immunity 2008; 76: 3293-3303.
23. Hasan Umit, Ahmet Tezel, Sebnem Bukavaz, Gulbin Unsal, Muserref Otkun, Ali Riza Soylu, et al. The Relationship between Virulence Factors of Helicobacter pylori and Severity of Gastritis in Infected Patients. Dig Dis Sci 2009; 54: 103-110.
24. Aime T Franco, Elizabeth Johnston, Uma Krishna, Yoshio Yamaoka, Dawn A. Israel, Toni A. Nagy, et al. Regulation of Gastric Carcinogenesis by Helicobacter pylori Virulence Factors. Cancer Res 2008; 68: 379-387.
25. Nilsson Anna Sillen, Lena Eriksson, Mona-Lisa Strand, Helena Enroth, Staffan Normark, et al. Correlation between cag Pathogenicity Island Composition and Helicobacter pylori-Associated Gastroduodenal Disease. Infection and Immunity 2003; 71: 6573-6581.
26. Jae Sung Ko, Jeong Kee Seo. Cag Pathogenicity Island of Helicobacter pylori in Korean Children. Helicobacter 2002; 7: 232-236.
27. Sarah Keates, Andrew C Keates, Michel Warny, Richard M Peek, Jr., Paul G. Murray, Ciaran P. Diff erential Activation og mitogen-Activated Protein Kinanses in AGS Gastric Epithelial Cells by cag+ and cag- Helicobacter pylori. The Journal of Immunology 1999; 163: 5552-5559.
28. Takahiko Kudo, Zhannat Z. Nurgalieva, Margaret E. Conner, Sue Crawford, Stefan Odenbreit. Correlation between Helicobacter pylori OipA Protein Expression and oipA Gene Switch Status. Journal of Clinical Microbiology 2004; 42: 2279-2281.
29. Yoshio Yamaoka, Dong H. Kwon, and David Y. Graham. A Mr 34,000 proinfl ammatory outer membrane protein (oipA) of Helicobacter pylori. PNAS 2000; 97: 7533-7538.
30. Sicheng Wen, Dominique Velin, Christian P. Felley, Likun Du, Pierre Michett i, and Qiang Pan-Hammarstrom. Expression of Helicobacter pylori Virulence Factors and Associated Expression Profiles of Inflammatory Genes in the Human Gastric Mucosa. Infection and Immunity 2007; 75: 5118-5126.