Mycoplasma pneumoniae Community Acquired Respiratory Distress Syndrome toxin expression reveals growth phase and infection-dependent regulation

Molecular Microbiology

Volumn 76, Issue 5, 2010, Pages 1127-1141

  Kannan, T R ^a   Musatovova, Oxana ^a   Balasubramanian, Sowmya ^a   Cagle, Marianna ^a   Jordan, Jarrat L ^b   Krunkosky, Thomas M ^c   Davis, Alan ^d   Hardy, Robert D ^e   Baseman, Joel B ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b CENTOCOR INC   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

^d Inverness Medical   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; COMMUNITY ACQUIRED RESPIRATORY DISTRESS SYNDROME TOXIN; MESSENGER RNA; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CELL; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BRONCHUS MUCOSA; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOGOLD ELECTRON MICROSCOPY; IN VITRO STUDY; LUNG PARENCHYMA; MAMMAL CELL; MOUSE; MYCOPLASMA PNEUMONIA; MYCOPLASMA PNEUMONIAE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; RNA TRANSLATION;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BASE SEQUENCE; CELL LINE; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; LUNG; LUNG DISEASES; MICE; MICE, INBRED BALB C; MYCOPLASMA PNEUMONIAE; PNEUMONIA, MYCOPLASMA; RESPIRATORY DISTRESS SYNDROME, ADULT; RNA, MESSENGER;

MAMMALIA; MYCOPLASMA; MYCOPLASMA PNEUMONIAE; MYCOPLASMATALES; SPIROPLASMA PHAGE 4;

EID: 77952835968     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2010.07092.x     Document Type: Article

References (54)

1. Balasubramanian, S., Kannan, T.R. Baseman, J.B. (2008) The surface-exposed carboxyl region of Mycoplasma pneumoniae elongation factor Tu interacts with fibronectin. Infect Immun 76 : 3116 3123.
2. Barile, M.F., Chandler, D.K., Yoshida, H., Grabowski, M.W., Harasawa, R. Ahmed, O.A. (1981) Hamster challenge potency assay for evaluation of Mycoplasma pneumoniae vaccines. Isr J Med Sci 17 : 682 686.
3. Baseman, J.B. Tully, J.G. (1997) Mycoplasmas: sophisticated, reemerging, and burdened by their notoriety. Emerg Infect Dis 3 : 21 32.
4. Baseman, J.B., Lange, M., Criscimagna, N.L., Giron, J.A. Thomas, C.A. (1995) Interplay between mycoplasmas and host target cells. Microb Pathog 19 : 105 116.
5. Chang, L.J., Chen, W.H., Minion, F.C. Shiuan, D. (2008) Mycoplasmas regulate the expression of heat-shock protein genes through CIRCE-HrcA interactions. Biochem Biophys Res Commun 367 : 213 218.
6. Dallo, S.F. Baseman, J.B. (2000) Intracellular DNA replication and long-term survival of pathogenic mycoplasmas. Microb Pathog 29 : 301 309.
7. Dallo, S.F., Kannan, T.R., Blaylock, M.W. Baseman, J.B. (2002) Elongation factor Tu and E1 beta subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in Mycoplasma pneumoniae. Mol Microbiol 46 : 1041 1051.
8. Dandekar, T., Huynen, M., Regula, J.T., Ueberle, B., Zimmermann, C.U., Andrade, M.A., et al. (2000) Re-annotating the Mycoplasma pneumoniae genome sequence: adding value, function and reading frames. Nucleic Acids Res 28 : 3278 3288.
9. Englard, S. Seifter, S. (1990) Precipitation techniques. Methods Enzymol 182 : 285 300.
10. Ermolaeva, M.D., Khalak, H.G., White, O., Smith, H.O. Salzberg, S.L. (2000) Prediction of transcription terminators in bacterial genomes. J Mol Biol 301 : 27 33.
11. Finlay, B.B. Falkow, S. (1997) Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev 61 : 136 169.
12. Gallegos, M.T., Schleif, R., Bairoch, A., Hofmann, K. Ramos, J.L. (1997) Arac/XylS family of transcriptional regulators. Microbiol Mol Biol Rev 61 : 393 410.
13. Halbedel, S., Hames, C. Stulke, J. (2004) In vivo activity of enzymatic and regulatory components of the phosphoenolpyruvate:sugar phosphotransferase system in Mycoplasma pneumoniae. J Bacteriol 186 : 7936 7943.
14. Halbedel, S., Eilers, H., Jonas, B., Busse, J., Hecker, M., Engelmann, S. Stulke, J. (2007) Transcription in Mycoplasma pneumoniae: analysis of the promoters of the ackA and ldh genes. J Mol Biol 371 : 596 607.
15. Hallamaa, K.M., Tang, S.L., Ficorilli, N. Browning, G.F. (2008) Differential expression of lipoprotein genes in Mycoplasma pneumoniae after contact with human lung epithelial cells, and under oxidative and acidic stress. BMC Microbiol 8 : 124.
16. Hara, K., Izumikawa, K., Kinoshita, I., Ota, M. Ikebe, A. (1974) Experimental infection with Mycoplasma pneumoniae in the young hamster: location of ferritin-labeled antibody binding to infective tissue. Tohoku J Exp Med 114 : 315 337.
17. Hardy, R.D., Jafri, H.S., Olsen, K., Wordemann, M., Hatfield, J., Rogers, B.B., et al. (2001) Elevated cytokine and chemokine levels and prolonged pulmonary airflow resistance in a murine Mycoplasma pneumoniae pneumonia model: a microbiologic, histologic, immunologic, and respiratory plethysmographic profile. Infect Immun 69 : 3869 3876.
18. Hardy, R.D., Jafri, H.S., Olsen, K., Hatfield, J., Iglehart, J., Rogers, B.B., et al. (2002) Mycoplasma pneumoniae induces chronic respiratory infection, airway hyperreactivity, and pulmonary inflammation: a murine model of infection-associated chronic reactive airway disease. Infect Immun 70 : 649 654.
19. Himmelreich, R., Hilbert, H., Plagens, H., Pirkl, E., Li, B.C. Herrmann, R. (1996) Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae. Nucleic Acids Res 24 : 4420 4449. (Pubitemid 26388629)
20. Hirst, T.R. (1999) Cholera toxin and Escherichia coli heat-labile enterotoxin. In The Comprehensive Sourcebook of Bacterial Protein Toxins. Alouf, J.E. Freer, J.H. (eds).
21. Hu, P.C., Collier, A.M. Baseman, J.B. (1975) Alterations in the metabolism of hamster tracheas in organ culture after infection by virulent Mycoplasma pneumoniae. Infect Immun 11 : 704 710.
22. Hu, P.C., Collier, A.M. Baseman, J.B. (1976) Interaction of virulent Mycoplasma pneumoniae with hamster tracheal organ cultures. Infect Immun 14 : 217 224.
23. Jaffe, J.D., Berg, H.C. Church, G.M. (2004) Proteogenomic mapping as a complementary method to perform genome annotation. Proteomics 4 : 59 77.
24. Kannan, T.R. Baseman, J.B. (2006) ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens. Proc Natl Acad Sci USA 103 : 6724 6729.
25. Kannan, T.R., Provenzano, D., Wright, J.R. Baseman, J.B. (2005) Identification and characterization of human surfactant protein A binding protein of Mycoplasma pneumoniae. Infect Immun 73 : 2828 2834.
26. Kannan, T.R., Musatovova, O., Gowda, P. Baseman, J.B. (2008) Characterization of a unique ClpB protein of Mycoplasma pneumoniae and its impact on growth. Infect Immun 76 : 5082 5092.
27. Krunkosky, T.M., Jordan, J.L., Chambers, E. Krause, D.C. (2007) Mycoplasma pneumoniae host-pathogen studies in an air-liquid culture of differentiated human airway epithelial cells. Microb Pathog 42 : 98 103.
28. Madsen, M.L., Nettleton, D., Thacker, E.L., Edwards, R. Minion, F.C. (2006) Transcriptional profiling of Mycoplasma hyopneumoniae during heat shock using microarrays. Infect Immun 74 : 160 166.
29. Murphy, G.F., Brody, A.R. Craighead, J.E. (1980) Exfoliation of respiratory epithelium in hamster tracheal organ cultures infected with Mycoplasma pneumoniae. Virchows Arch A Pathol Anat Histol 389 : 93 102.
30. Musatovova, O., Dhandayuthapani, S. Baseman, J.B. (2006) Transcriptional heat shock response in the smallest known self-replicating cell, Mycoplasma genitalium. J Bacteriol 188 : 2845 2855.
31. Musatovova, O., Kannan, T.R. Baseman, J.B. (2008) Genomic analysis reveals Mycoplasma pneumoniae repetitive element 1-mediated recombination in a clinical isolate. Infect Immun 76 : 1639 1648.
32. Narberhaus, F. (1999) Negative regulation of bacterial heat shock genes. Mol Microbiol 31 : 1 8.
33. Nicholson, T.L., Olinger, L., Chong, K., Schoolnik, G. Stephens, R.S. (2003) Global stage-specific gene regulation during the developmental cycle of Chlamydia trachomatis. J Bacteriol 185 : 3179 3189.
34. Payne, S.M. (2003) Regulation of bacterial toxin synthesis by iron. In Bacterial Protein Toxins. Burns, D.L., Barbieri, J.T., Iglewski, B.H. Rappuoli, R. (eds).
35. Rambow-Larsen, A.A. Weiss, A.A. (2004) Temporal expression of pertussis toxin and Ptl secretion proteins by Bordetella pertussis. J Bacteriol 186 : 43 50.
36. Razin, S. (1983) Cell lysis and isolation of membranes. In Methods in Mycoplasmology, Vol. 1. Razin, S. Tully, J.G. (eds).
37. Razin, S., Yogev, D. Naot, Y. (1998) Molecular biology and pathogenicity of mycoplasmas. Microbiol Mol Biol Rev 62 : 1094 1156.
38. Regula, J.T., Ueberle, B., Boguth, G., Gorg, A., Schnolzer, M., Herrmann, R. Frank, R. (2000) Towards a two-dimensional proteome map of Mycoplasma pneumoniae. Electrophoresis 21 : 3765 3780.
39. Rood, J.I. (1998) Virulence genes of Clostridium perfringens. Annu Rev Microbiol 52 : 333 360.
40. Samuelsson, T., Macao, B. Bolske, G. (1997) A 13-kDa protein with a helix-turn-helix motif is encoded by bacterial operons related to the SRP pathway. Biochem Biophys Res Commun 231 : 839 843.
41. Snyder, J.A., Haugen, B.J., Buckles, E.L., Lockatell, C.V., Johnson, D.E., Donnenberg, M.S., et al. (2004) Transcriptome of uropathogenic Escherichia coli during urinary tract infection. Infect Immun 72 : 6373 6381.
42. Srivastava, R., Sinha, V.B. Srivastava, B.S. (1980) Events in the pathogenesis of experimental cholera: role of bacterial adherence and multiplication. J Med Microbiol 13 : 1 9.
43. Stibitz, S. (2003) Two-component systems. In Bacterial Protein Toxins. Burns, D.L., Barbieri, J.T., Iglewski, B.H. Rappuoli, R. (eds).
44. Strohmaier, H., Remler, P., Renner, W. Hogenauer, G. (1995) Expression of genes kdsA and kdsB involved in 3-deoxy-D-manno-octulosonic acid metabolism and biosynthesis of enterobacterial lipopolysaccharide is growth phase regulated primarily at the transcriptional level in Escherichia coli K-12. J Bacteriol 177 : 4488 4500.
45. Thompson, L.J., Merrell, D.S., Neilan, B.A., Mitchell, H., Lee, A. Falkow, S. (2003) Gene expression profiling of Helicobacter pylori reveals a growth-phase-dependent switch in virulence gene expression. Infect Immun 71 : 2643 2655.
46. Tuomanen, E. Weiss, A. (1985) Characterization of two adhesins of Bordetella pertussis for human ciliated respiratory-epithelial cells. J Infect Dis 152 : 118 125.
47. Ueberle, B., Frank, R. Herrmann, R. (2002) The proteome of the bacterium Mycoplasma pneumoniae: comparing predicted open reading frames to identified gene products. Proteomics 2 : 754 764.
48. Ursi, D., Dirven, K., Loens, K., Ieven, M. Goossens, H. (2003) Detection of Mycoplasma pneumoniae in respiratory samples by real-time PCR using an inhibition control. J Microbiol Methods 55 : 149 153.
49. VanBogelen, R.A., Greis, K.D., Blumenthal, R.M., Tani, T.H. Matthews, R.G. (1999) Mapping regulatory networks in microbial cells. Trends Microbiol 7 : 320 328.
50. Wagner, V.E., Bushnell, D., Passador, L., Brooks, A.I. Iglewski, B.H. (2003) Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J Bacteriol 185 : 2080 2095.
51. Waites, K.B. Talkington, D.F. (2004) Mycoplasma pneumoniae and its role as a human pathogen. Clin Microbiol Rev 17 : 697 728.
52. Weiner, J., 3rd., Herrmann, R. Browning, G.F. (2000) Transcription in Mycoplasma pneumoniae. Nucleic Acids Res 28 : 4488 4496.
53. Weiner, J., 3rd., Zimmerman, C.U., Gohlmann, H.W. Herrmann, R. (2003) Transcription profiles of the bacterium Mycoplasma pneumoniae grown at different temperatures. Nucleic Acids Res 31 : 6306 6320.
54. Xu, J. Johnson, R.C. (1995) Identification of genes negatively regulated by Fis: Fis and RpoS comodulate growth-phase-dependent gene expression in Escherichia coli. J Bacteriol 177 : 938 947.