Stand up!

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 5, 2010, Pages 2050-2053

  Rubin, Janet ^a   Rubin, Clinton ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Stony Brook University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; COLLAGEN TYPE 1; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; NARCOTIC AGENT; OSTEOCLAST DIFFERENTIATION FACTOR; SCLEROSTIN; TRANSCRIPTION FACTOR NFAT; WNT PROTEIN; CALCIUM;

BONE TURNOVER; EDITORIAL; HUMAN; HYPERCALCEMIA; IMMOBILIZATION; NONHUMAN; OSTEOBLAST; OSTEOCYTE; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STANDING; WEIGHT BEARING; ADULT; BLOOD; BODY POSTURE; CASE REPORT; COLOSTOMY; CYTOLOGY; FRACTURE; MALE; NEPHRECTOMY; NOTE; PATHOLOGY; TRAFFIC ACCIDENT;

ACCIDENTS, TRAFFIC; BONE RESORPTION; CALCIUM; COLOSTOMY; FRACTURES, BONE; HUMANS; IMMOBILIZATION; MALE; NEPHRECTOMY; OSTEOCYTES; POSTURE; YOUNG ADULT;

EID: 77952787363     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0608     Document Type: Editorial

References (24)

1. Roberts D, Lee W, Cuneo RC, Wittmann J, Ward G, Flatman R, McWhinney B, Hickman PE 1998 Longitudinal study of bone turnover after acute spinal cord injury. J Clin Endocrinol Metab 83: 415-422 (Pubitemid 28496515)
2. Warden SJ, Fuchs RK, Castillo AB, Nelson IR, Turner CH 2007 Exercise when young provides lifelong benefits to bone structure and strength. J Bone Miner Res 22:251-259
3. Gilchrist NL, Frampton CM, Acland RH, Nicholls MG, March RL, Maguire P, Heard A, Reilly P, Marshall K 2007 Alendronate prevents bone loss in patients with acute spinal cord injury: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 92:1385-1390
4. Shackelford LC, LeBlanc AD, Driscoll TB, Evans HJ, Rianon NJ, Smith SM, Spector E, Feeback DL, Lai D 2004 Resistance exercise as a countermeasure to disuse-induced bone loss. J Appl Physiol 97:119-129
5. Gaudio A, Pennisi P, Bratengeier C, Torrisi V, Lindner B, Mangiafico RA, Pulvirenti I, Hawa G, Tringali G, Fiore CE 2010 Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization induced bone loss. J Clin Endocrinol Metab 95:2248-2253
6. Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, Kohno K, Ito M, Takeshita S, Ikeda K 2007 Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab 5:464-475
7. Lin C, Jiang X, Dai Z, Guo X, Weng T, Wang J, Li Y, Feng G, Gao X, He L 2009 Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/β-catenin signaling. J Bone Miner Res 24:1651-1661
8. Brunkow ME, Gardner JC, Van Ness J, Paeper BW, Kovacevich BR, Proll S, Skonier JE, Zhao L, Sabo PJ, Fu Y, Alisch RS, Gillett L, Colbert T, Tacconi P, Galas D, Hamersma H, Beighton P, Mulligan J 2001 Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet 68:577-589
9. Loots GG, Kneissel M, Keller H, Baptist M, Chang J, Collette NM, Ovcharenko D, Plajzer-Frick I, Rubin EM 2005 Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res 15:928-935
10. van Bezooijen RL, Roelen BA, Visser A, van der Wee-Pals L, de Wilt E, Karperien M, Hamersma H, Papapoulos SE, ten Dijke P, Löwik CW 2004 Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med 199:805-814
11. Robling AG, Niziolek PJ, Baldridge LA, Condon KW, Allen MR, Alam I, Mantila SM, Gluhak-Heinrich J, Bellido TM, Harris SE, Turner CH 2008 Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem283:5866-5875
12. Semënov M, Tamai K, He X 2005 SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem 280:26770-26775 (Pubitemid 41040710)
13. Rubin J, Rubin C, Jacobs CR 2006 Molecular pathways mediating mechanical signaling in bone. Gene 367:1-16
14. Case N, Ma M, Sen B, Xie Z, Gross TS, Rubin J 2008 β-Catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem 283:29196-29205
15. Glass 2nd DA, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G 2005 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8:751-764
16. Minaire P, Edouard C, Arlot M, Meunier PJ 1984 Marrow changes in paraplegic patients. Calcif Tissue Int 36:338-340
17. David V, Martin A, Lafage-Proust MH, Malaval L, Peyroche S, Jones DB, Vico L, Guignandon A 2007 Mechanical loading down-regulates peroxisome proliferator-activated receptor γ in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology 148:2553-2562
18. Sen B, Xie Z, Case N, Ma M, Rubin C, Rubin J 2008 Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable β-catenin signal. Endocrinology 149:6065-6075
19. Sen B, Styner M, Xie Z, Case N, Rubin CT, Rubin J 2009 Mechanical loading regulates NFATc1 and β-catenin signaling through a GSK3β control node. J Biol Chem 284:34607-34617
20. Rubin CT, Capilla E, Luu YK, Busa B, Crawford H, Nolan DJ, Mittal V, Rosen CJ, Pessin JE, Judex S 2007 Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals. Proc Natl Acad Sci USA 104:17879-17884
21. Luu YK, Capilla E, Rosen CJ, Gilsanz V, Pessin JE, Judex S, Rubin CT 2009 Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity. J Bone Miner Res 24:50-61
22. Ozcivici E, Luu YK, Adler B, Qin YX, Rubin J, Judex S, Rubin CT 2010 Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol 6:50-59
23. Rubin C, Xu G, Judex S 2001 The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli. FASEB J 15:2225-2229
24. Gilsanz V, Wren TA, Sanchez M, Dorey F, Judex S, Rubin C 2006 Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD. J Bone Miner Res 21:1464-1474