Interaction between DNA polymerase λ and anticancer nucleoside analogs

Journal of Biological Chemistry

Volumn 285, Issue 22, 2010, Pages 16874-16879

  Garcia Diaz, Miguel ^a,c   Murray, Michael S ^a   Kunkel, Thomas A ^a   Chou, Kai Ming ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER ACTIVITIES; ATOMIC-LEVEL RESOLUTION; BASE PAIRS; BINDING POCKETS; CHAIN TERMINATIONS; CYTARABINE; CYTOTOXIC EFFECTS; DNA POLYMERASE; GEMCITABINE; HUMAN DNA POLYMERASE;

CRYSTAL ATOMIC STRUCTURE; DNA;

GENES;

CYTARABINE; DNA; DNA DIRECTED DNA POLYMERASE LAMBDA; GEMCITABINE; NUCLEOTIDYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG BINDING SITE; DRUG PROTEIN BINDING; ENZYME STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING;

ANIMALS; ANTINEOPLASTIC AGENTS; CYTARABINE; DEOXYCYTIDINE; DNA; DNA POLYMERASE BETA; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; MICE; MODELS, MOLECULAR; NUCLEOSIDES; NUCLEOTIDES;

EID: 77952785941     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.094391     Document Type: Article

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