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Volumn 97, Issue 6, 2010, Pages 892-901

Endoglin negatively regulates transforming growth factor β1-induced profibrotic responses in intestinal fibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; ENG PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77952777431     PISSN: 00071323     EISSN: 13652168     Source Type: Journal    
DOI: 10.1002/bjs.6996     Document Type: Article
Times cited : (31)

References (47)
  • 1
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448: 427-434.
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 5
    • 33749599530 scopus 로고    scopus 로고
    • Expression and regulation of connective tissue growth, factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease
    • Beddy D, Mulsow J, Watson RW, Fitzpatrick JM, O'Connell PR. Expression and regulation of connective tissue growth, factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease. Br J Surg 2006; 93: 1290-1296.
    • (2006) Br J Surg , vol.93 , pp. 1290-1296
    • Beddy, D.1    Mulsow, J.2    Watson, R.W.3    Fitzpatrick, J.M.4    O'Connell, P.R.5
  • 6
    • 1642540081 scopus 로고    scopus 로고
    • Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease
    • Beddy D, Watson RW, Fitzpatrick JM, O'Connell PR. Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease. Br J Surg 2004; 91: 72-77.
    • (2004) Br J Surg , vol.91 , pp. 72-77
    • Beddy, D.1    Watson, R.W.2    Fitzpatrick, J.M.3    O'Connell, P.R.4
  • 7
    • 28244489246 scopus 로고    scopus 로고
    • Transforming growth, factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ER.K1/2 mitogen activated protein kinase cell, signaling
    • MulsowJJ, Watson RW, FitzpatrickJM, O'Connell PR. Transforming growth, factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ER.K1/2 mitogen activated protein kinase cell, signaling. Ann Surg 2005; 242: 880-887.
    • (2005) Ann Surg , vol.242 , pp. 880-887
    • Mulsow, J.J.1    Watson, R.W.2    Fitzpatrick, J.M.3    O'Connell, P.R.4
  • 8
    • 0033971785 scopus 로고    scopus 로고
    • Stricture formation in Crohn's disease: The role of intestinal fibroblasts
    • Regan MC, Flavin BM, Fitzpatrick JM, O'Connell PR. Stricture formation in Crohn's disease: the role of intestinal fibroblasts. Ann Surg 2000; 231: 46-50.
    • (2000) Ann Surg , vol.231 , pp. 46-50
    • Regan, M.C.1    Flavin, B.M.2    Fitzpatrick, J.M.3    O'Connell, P.R.4
  • 9
    • 0033497296 scopus 로고    scopus 로고
    • Transforming growth factor-betas and their signaling receptors are coexpressed in Crohn's disease
    • di Mola FF, Friess H, Scheuren A, Di Sebastiano P, Graber H, Egger B et al. Transforming growth factor-betas and their signaling receptors are coexpressed in Crohn's disease. Ann Surg 1999; 229: 67-75.
    • (1999) Ann Surg , vol.229 , pp. 67-75
    • Di Mola, F.F.1    Friess, H.2    Scheuren, A.3    Di Sebastiano, P.4    Graber, H.5    Egger, B.6
  • 10
    • 54349125596 scopus 로고    scopus 로고
    • Transcriptomic analysis of intestinal, fibrosis-associated gene expression in response to medical therapy in Crohn's disease
    • Burke JP, Ferrante M, Dejaegher K, Watson RW, Docherty NG, De Hertogh G et al. Transcriptomic analysis of intestinal, fibrosis-associated gene expression in response to medical therapy in Crohn's disease. Inflamm. Bowel Dis 2008; 14:1197-1204.
    • (2008) Inflamm. Bowel Dis , vol.14 , pp. 1197-1204
    • Burke, J.P.1    Ferrante, M.2    Dejaegher, K.3    Watson, R.W.4    Docherty, N.G.5    De Hertogh, G.6
  • 11
    • 0036073299 scopus 로고    scopus 로고
    • Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts
    • McKaig BC, Hughes K, Tighe PJ, Mahida YR. Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts. Am J Physiol Cell Physiol 2002; 282: C172-C182.
    • (2002) Am J Physiol Cell Physiol , vol.282
    • McKaig, B.C.1    Hughes, K.2    Tighe, P.J.3    Mahida, Y.R.4
  • 12
    • 0037404842 scopus 로고    scopus 로고
    • Endoglin (CD105): A target for anti-angiogenetic cancer therapy
    • Fonsatti E, Altomonte M, Arslan P, Maio M. Endoglin (CD105): a target for anti-angiogenetic cancer therapy. Curr Drug Targets 2003; 4: 291-296.
    • (2003) Curr Drug Targets , vol.4 , pp. 291-296
    • Fonsatti, E.1    Altomonte, M.2    Arslan, P.3    Maio, M.4
  • 13
    • 38149133230 scopus 로고    scopus 로고
    • Endoglin-mediated vascular remodeling: Mechanisms underlying hereditary hemorrhagic telangiectasia
    • Lebrin F, Mummery CL. Endoglin-mediated vascular remodeling: mechanisms underlying hereditary hemorrhagic telangiectasia. Trends CardiovascMed 2008; 18: 25-32.
    • (2008) Trends CardiovascMed , vol.18 , pp. 25-32
    • Lebrin, F.1    Mummery, C.L.2
  • 14
    • 36849054447 scopus 로고    scopus 로고
    • Novel biochemical pathways of endoglin in vascular cell physiology
    • Bernabeu C, Conley BA, Vary CP. Novel biochemical pathways of endoglin in vascular cell physiology. J Cell Biochem 2007; 102: 1375-1388.
    • (2007) J Cell Biochem , vol.102 , pp. 1375-1388
    • Bernabeu, C.1    Conley, B.A.2    Vary, C.P.3
  • 15
    • 0036069793 scopus 로고    scopus 로고
    • Dysregulation of transforming growth factor beta signaling in scleroderma: Overexpression of endoglin in cutaneous scleroderma fibroblasts
    • Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X et al. Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. Arthritis Rheum 2002; 46: 1857-1865.
    • (2002) Arthritis Rheum , vol.46 , pp. 1857-1865
    • Leask, A.1    Abraham, D.J.2    Finlay, D.R.3    Holmes, A.4    Pennington, D.5    Shi-Wen, X.6
  • 17
    • 3142676670 scopus 로고    scopus 로고
    • Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine Adriamycin-induced nephropathy
    • Sadlier DM, Connolly SB, Kieran NE, Roxburgh S, Brazil DP, Kairaitis L et al. Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine Adriamycin-induced nephropathy. J Biol Chem 2004; 279: 29670-29680.
    • (2004) J Biol Chem , vol.279 , pp. 29670-29680
    • Sadlier, D.M.1    Connolly, S.B.2    Kieran, N.E.3    Roxburgh, S.4    Brazil, D.P.5    Kairaitis, L.6
  • 18
    • 33747198440 scopus 로고    scopus 로고
    • Increased intrahepatic and circulating levels of endoglin, a TGF-beta 1 co-receptor, in patients with chronic hepatitis C virus infection: Relationship to histological and serum markers of hepatic fibrosis
    • Clemente M, Nunez O, Lorente R, Rincón D, Matula A, Salcedo M et al. Increased intrahepatic and circulating levels of endoglin, a TGF-beta 1 co-receptor, in patients with chronic hepatitis C virus infection: relationship to histological and serum markers of hepatic fibrosis. J Viral Hepat 2006; 13: 625-632.
    • (2006) J Viral Hepat , vol.13 , pp. 625-632
    • Clemente, M.1    Nunez, O.2    Lorente, R.3    Rincón, D.4    Matula, A.5    Salcedo, M.6
  • 19
    • 0032516862 scopus 로고    scopus 로고
    • Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer
    • Jonk LJ, Itoh S, Heldin CH, ten Dijke P, Kruijer W. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer. J Biol Chem 1998;273: 21145-21152.
    • (1998) J Biol Chem , vol.273 , pp. 21145-21152
    • Jonk, L.J.1    Itoh, S.2    Heldin, C.H.3    Ten Dijke, P.4    Kruijer, W.5
  • 20
    • 65249154053 scopus 로고    scopus 로고
    • Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor betal -mediated activation of intestinal fibroblasts
    • Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, O'Connell PR. Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor betal -mediated activation of intestinal fibroblasts. Br J Surg 2009;96:541-551.
    • (2009) Br J Surg , vol.96 , pp. 541-551
    • Burke, J.P.1    Watson, R.W.2    Murphy, M.3    Docherty, N.G.4    Coffey, J.C.5    O'Connell, P.R.6
  • 22
    • 3242669059 scopus 로고    scopus 로고
    • Critical involvement of stress-activated mitogen-activated protein kinases in the regulation of intracellular adhesion molecule-1 in serosal fibroblasts isolated from patients with Crohn's disease J Am
    • Beddy DJ, Watson WR, FitzpatrickJM, O'Connell PR. Critical involvement of stress-activated mitogen-activated protein kinases in the regulation of intracellular adhesion molecule-1 in serosal fibroblasts isolated from patients with Crohn's disease, J Am Coll Surg 2004; 199: 234-242.
    • (2004) Coll Surg , vol.199 , pp. 234-242
    • Beddy, D.J.1    Watson, W.R.2    Fitzpatrick, J.M.3    O'Connell, P.R.4
  • 24
    • 0037369778 scopus 로고    scopus 로고
    • Smad3 mediates the TGF-beta-induced contraction of type i collagen gels by mouse embryo fibroblasts
    • Liu X, Wen FQ, Kobayashi T, Abe S, Fang Q, Piek E et al. Smad3 mediates the TGF-beta-induced contraction of type I collagen gels by mouse embryo fibroblasts. Cell Motil Cytoskeleton 2003; 54: 248-253.
    • (2003) Cell Motil Cytoskeleton , vol.54 , pp. 248-253
    • Liu, X.1    Wen, F.Q.2    Kobayashi, T.3    Abe, S.4    Fang, Q.5    Piek, E.6
  • 26
    • 0023784185 scopus 로고
    • Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line
    • Gougos A, Letarte M. Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line. J Immunol 1988; 141: 1925-1933.
    • (1988) J Immunol , vol.141 , pp. 1925-1933
    • Gougos, A.1    Letarte, M.2
  • 27
    • 0026646785 scopus 로고
    • Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
    • Cheifetz S, Bellón T, Calés C., Vera S, Bernabeu C., Massagué J et al. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem 1992; 267: 19027-19030.
    • (1992) J Biol Chem , vol.267 , pp. 19027-19030
    • Cheifetz, S.1    Bellón, T.2    Calés, C.3    Vera, S.4    Bernabeu, C.5    Massagué, J.6
  • 29
    • 0035503538 scopus 로고    scopus 로고
    • Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD 105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide
    • Takahashi N, Haba A, Matsuno F, Seon BK. Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD 105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Cancer Res 2001; 61: 7846-7854.
    • (2001) Cancer Res , vol.61 , pp. 7846-7854
    • Takahashi, N.1    Haba, A.2    Matsuno, F.3    Seon, B.K.4
  • 31
    • 0035797556 scopus 로고    scopus 로고
    • Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia
    • Trembath RC, Thomson JR, Machado RD, Morgan NV, Atkinson C, Winship I et al. Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. N Engl J Med 2001; 345:325-334.
    • (2001) N Engl J Med , vol.345 , pp. 325-334
    • Trembath, R.C.1    Thomson, J.R.2    Machado, R.D.3    Morgan, N.V.4    Atkinson, C.5    Winship, I.6
  • 32
    • 0038468558 scopus 로고    scopus 로고
    • Smad3: A key player in pathogenetic mechanisms dependent on TGF-beta
    • Roberts AB, Russo A, Felici A, Flanders KC. Smad3 : a key player in pathogenetic mechanisms dependent on TGF-beta. Ann NY Acad Sci 2003; 995: 1-10.
    • (2003) Ann NY Acad Sci , vol.995 , pp. 1-10
    • Roberts, A.B.1    Russo, A.2    Felici, A.3    Flanders, K.C.4
  • 33
    • 21644452716 scopus 로고    scopus 로고
    • Interaction and functional interplay between endoglin and ALK-1 two components of the endothelial transforming growth factor-beta receptor complex
    • Blanco FJ, Santibanez JF, Guerrero-Esteo M, Langa C, Vary CP, Bernabeu C. Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex. J Cell Physiol 2005; 204: 574-584.
    • (2005) J Cell Physiol , vol.204 , pp. 574-584
    • Blanco, F.J.1    Santibanez, J.F.2    Guerrero-Esteo, M.3    Langa, C.4    Vary, C.P.5    Bernabeu, C.6
  • 34
    • 33845624247 scopus 로고    scopus 로고
    • Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling
    • Santibanez JF, Letamendia A, Perez-Barriocanal F, Silvestri C, Saura M, Vary CP et al. Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling. J Cell Physiol 2007; 210: 456-468.
    • (2007) J Cell Physiol , vol.210 , pp. 456-468
    • Santibanez, J.F.1    Letamendia, A.2    Perez-Barriocanal, F.3    Silvestri, C.4    Saura, M.5    Vary, C.P.6
  • 35
    • 34347230515 scopus 로고    scopus 로고
    • Endoglin differentially modulates antagonistic transforming growth factor-betal and BMP-7 signaling
    • Schemer O, Meurer SK, Tihaa L, Gressner AM, Weiskirchen R. Endoglin differentially modulates antagonistic transforming growth factor-betal and BMP-7 signaling. J Biol Chem. 2007; 282: 13 934-13 943.
    • (2007) J Biol Chem. , vol.282 , pp. 13934-13943
    • Schemer, O.1    Meurer, S.K.2    Tihaa, L.3    Gressner, A.M.4    Weiskirchen, R.5
  • 37
    • 36048973196 scopus 로고    scopus 로고
    • Endoglin inhibits prostate cancer motility via activation of the ALK2-Smadl pathway
    • Craft CS, Romero D, Vary CP, Bergan RC. Endoglin inhibits prostate cancer motility via activation of the ALK2-Smadl pathway. Oncogene 2007; 26: 7240-7250.
    • (2007) Oncogene , vol.26 , pp. 7240-7250
    • Craft, C.S.1    Romero, D.2    Vary, C.P.3    Bergan, R.C.4
  • 38
    • 3242716984 scopus 로고    scopus 로고
    • CD105 inhibits transforming growth factor-beta-Smad3 signalling
    • Guo B, Slevin M, Li C, Parameshwar S, Liu D, Kumar P et al. CD105 inhibits transforming growth factor-beta-Smad3 signalling. Anticancer Res 2004; 24: 1337-1345.
    • (2004) Anticancer Res , vol.24 , pp. 1337-1345
    • Guo, B.1    Slevin, M.2    Li, C.3    Parameshwar, S.4    Liu, D.5    Kumar, P.6
  • 39
    • 3543041235 scopus 로고    scopus 로고
    • Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins
    • Sanz-Rodriguez F, Guerrero-Esteo M, Botella LM, Banville D, Vary CP, Bernabeu C. Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins. J Biol Chem. 2004; 279:32 858-32 868.
    • (2004) J Biol Chem. , vol.279 , pp. 32858-32868
    • Sanz-Rodriguez, F.1    Guerrero-Esteo, M.2    Botella, L.M.3    Banville, D.4    Vary, C.P.5    Bernabeu, C.6
  • 40
    • 0032483544 scopus 로고    scopus 로고
    • Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling
    • Shi Y, Wang YF, Jayaraman L, Yang H, Massagué J, Pavletich NP. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell 1998; 94: 585-594.
    • (1998) Cell , vol.94 , pp. 585-594
    • Shi, Y.1    Wang, Y.F.2    Jayaraman, L.3    Yang, H.4    Massagué, J.5    Pavletich, N.P.6
  • 41
    • 0033534573 scopus 로고    scopus 로고
    • Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3
    • Yagi K, Goto D, Hamamoto T, Takenoshita S, Kato M, Miyazono K. Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3. J Biol Chem 1999; 274: 703-709.
    • (1999) J Biol Chem , vol.274 , pp. 703-709
    • Yagi, K.1    Goto, D.2    Hamamoto, T.3    Takenoshita, S.4    Kato, M.5    Miyazono, K.6
  • 42
    • 67650501166 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamineinduced hepatic fibrosis in mice
    • Latella G, Vetuschi A, Sferra R, Catitti V, D'Angelo A, Zanninelli G et al. Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamineinduced hepatic fibrosis in mice. Liver Int. 2009; 29: 997-1009.
    • (2009) Liver Int. , vol.29 , pp. 997-1009
    • Latella, G.1    Vetuschi, A.2    Sferra, R.3    Catitti, V.4    D'Angelo, A.5    Zanninelli, G.6
  • 43
    • 58649088728 scopus 로고    scopus 로고
    • Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis
    • Latella G, Vetuschi A, Sferra R, Zanninelli G, D'Angelo A, Catitti V et al. Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis. Eur J Clin Invest. 2009; 39: 145-156.
    • (2009) Eur J Clin Invest. , vol.39 , pp. 145-156
    • Latella, G.1    Vetuschi, A.2    Sferra, R.3    Zanninelli, G.4    D'Angelo, A.5    Catitti, V.6
  • 44
    • 30744478450 scopus 로고    scopus 로고
    • The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbetal responses in human proximal-tubule epithelial cells
    • Phanish MK, Wahab NA, Colville-Nash P, Hendry BM, Dockrell ME. The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbetal responses in human proximal-tubule epithelial cells. Biochem. J 2006; 393: 601-607.
    • (2006) Biochem. J , vol.393 , pp. 601-607
    • Phanish, M.K.1    Wahab, N.A.2    Colville-Nash, P.3    Hendry, B.M.4    Dockrell, M.E.5
  • 45
    • 68949101788 scopus 로고    scopus 로고
    • Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes - But without modulating bone morphogenetic protein 7 signaling
    • Gressner OA, Lahme B, Siluschek M, Rehbein K, Weiskirchen R, Gressner AM. Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes - but without modulating bone morphogenetic protein 7 signaling. Hepatology 2009; 49: 2021-2030.
    • (2009) Hepatology , vol.49 , pp. 2021-2030
    • Gressner, O.A.1    Lahme, B.2    Siluschek, M.3    Rehbein, K.4    Weiskirchen, R.5    Gressner, A.M.6
  • 46
    • 36348932917 scopus 로고    scopus 로고
    • Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes
    • Weng HL, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H et al. Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. Hepatology 2007; 46: 1257-1270.
    • (2007) Hepatology , vol.46 , pp. 1257-1270
    • Weng, H.L.1    Ciuclan, L.2    Liu, Y.3    Hamzavi, J.4    Godoy, P.5    Gaitantzi, H.6


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