Azathioprine or mercaptopurine-induced acute pancreatitis is not a disease-specific phenomenon

Alimentary Pharmacology and Therapeutics

Volumn 31, Issue 12, 2010, Pages 1322-1329

  Van Geenen, E J M ^a   De Boer, N K H ^a   Stassen, P ^b   Linskens, R K ^c   Bruno, M J ^d   Mulder, C J J ^a   Stegeman, C A ^e   Van Bodegraven, A A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ST ANNA HOSPITAL   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; MERCAPTOPURINE;

ACUTE PANCREATITIS; ADULT; AGED; ARTICLE; CROHN DISEASE; DRUG RESPONSE; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; ULCERATIVE COLITIS; VASCULITIS;

6-MERCAPTOPURINE; ACUTE DISEASE; ADOLESCENT; ADULT; AGED; ANTIMETABOLITES; AZATHIOPRINE; CROHN DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; PANCREATITIS; RETROSPECTIVE STUDIES; STATISTICS AS TOPIC; YOUNG ADULT;

EID: 77952756387     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2010.04287.x     Document Type: Article

References (36)

1. Balani AR, Grendell JH. Drug-induced pancreatitis: incidence, management and prevention. Drug Saf 2008 31 : 823 837.
2. Badalov N, Baradarian R, Iswara K, Li J, Steinberg W, Tenner S. Drug-induced acute pancreatitis: an evidence-based review. Clin Gastroenterol Hepatol 2007 5 : 648 661.
3. Ewe K, Press AG, Singe CC, et al. Azathioprine combined with prednisolone or monotherapy with prednisolone in active Crohn's disease. Gastroenterology 1993 105 : 367 372.
4. Korelitz BI, Adler DJ, Mendelsohn RA, Sacknoff AL. Long-term experience with 6-mercaptopurine in the treatment of Crohn's disease. Am J Gastroenterol 1993 88 : 1198 1205.
5. De Boer NK, van Bodegraven AA, Jharap B, de GP, Mulder CJ. Drug Insight: pharmacology and toxicity of thiopurine therapy in patients with IBD. Nat Clin Pract Gastroenterol Hepatol 2007 4 : 686 694.
6. Guillevin L, Pagnoux C. Treatment of systemic vasculitides. Rev Prat 2008 58 : 541 544.
7. Weersma RK, Peters FT, Oostenbrug LE, et al. Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases. Aliment Pharmacol Ther 2004 20 : 843 850.
8. Bajaj JS, Saeian K, Varma RR, et al. Increased rates of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: a tertiary referral center experience. Am J Gastroenterol 2005 100 : 1121 1125.
9. de Jong DJ, Derijks LJ, Naber AH, Hooymans PM, Mulder CJ. Safety of thiopurines in the treatment of inflammatory bowel disease. Scand J Gastroenterol Suppl 2003 2 : 69 72.
10. Ananthakrishnan AN, Attila T, Otterson MF, et al. Severe pulmonary toxicity after azathioprine/6-mercaptopurine initiation for the treatment of inflammatory bowel disease. J Clin Gastroenterol 2007 41 : 682 688.
11. Stange EF, Travis SP. The European consensus on ulcerative colitis: new horizons? Gut 2008 57 : 1029 1031.
12. Stange EF, Travis SP, Vermeire S, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis. Gut 2006 55 (Suppl. 1 i1 15.
13. Travis SP, Stange EF, Lemann M, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut 2006 55 (Suppl. 1 i16 35.
14. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 1994 37 : 187 192.
15. Helzer JE, Stillings WA, Chammas S, Norland CC, Alpers DH. A controlled study of the association between ulcerative colitis and psychiatric diagnoses. Dig Dis Sci 1982 27 : 513 518.
16. Gisbert JP, Gomollon F, Mate J, Pajares JM. Questions and answers on the role of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease. Gastroenterol Hepatol 2002 25 : 401 415.
17. Sood A, Midha V, Sood N, Bansal M. Long term results of use of azathioprine in patients with ulcerative colitis in India. World J Gastroenterol 2006 12 : 7332 7336.
18. Sandborn W, Sutherland L, Pearson D, May G, Modigliani R, Prantera C. Azathioprine or 6-mercaptopurine for inducing remission of Crohn's disease. Cochrane Database Syst Rev 2000 2 : CD000545.
19. Lindkvist B, Appelros S, Manjer J, Berglund G, Borgstrom A. A prospective cohort study of smoking in acute pancreatitis. Pancreatology 2008 8 : 63 70.
20. Dubinsky MC, Feldman EJ, Abreu MT, Targan SR, Vasiliauskas EA. Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine. Am J Gastroenterol 2003 98 : 1058 1063.
21. Krynetski EY, Tai HL, Yates CR, et al. Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms. Pharmacogenetics 1996 6 : 279 290.
22. De RL, Van Dieren JM, Van Deventer HJ, et al. Pharmacogenetics of thiopurine therapy in paediatric IBD patients. Aliment Pharmacol Ther 2006 23 : 1137 1141.
23. Marinaki AM, Duley JA, Arenas M, et al. Mutation in the ITPA gene predicts intolerance to azathioprine. Nucleosides Nucleotides Nucleic Acids 2004 23 : 1393 1397.
24. Gearry RB, Roberts RL, Barclay ML, Kennedy MA. Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine. Pharmacogenetics 2004 14 : 779 781.
25. de Boer NK, Reinisch W, Teml A, et al. 6-Thioguanine treatment in inflammatory bowel disease: a critical appraisal by a European 6-TG working party. Digestion 2006 73 : 25 31.
26. de Boer NK, Derijks LJ, Gilissen LP, et al. On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprine or 6-mercaptopurine intolerant IBD patients. World J Gastroenterol 2005 11 : 5540 5544.
27. Yadav D, Lowenfels AB. Trends in the epidemiology of the first attack of acute pancreatitis: a systematic review. Pancreas 2006 33 : 323 330.
28. Blomgren KB, Sundstrom A, Steineck G, Genell S, Sjostedt S, Wiholm BE. A Swedish case-control network for studies of drug-induced morbidity - acute pancreatitis. Eur J Clin Pharmacol 2002 58 : 275 283.
29. Weber P, Seibold F, Jenss H. Acute pancreatitis in Crohn's disease. J Clin Gastroenterol 1993 17 : 286 291.
30. Bermejo F, Lopez-Sanroman A, Taxonera C, et al. Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine-induced pancreatitis. Aliment Pharmacol Ther 2008 28 : 623 628.
31. Barthet M, Hastier P, Bernard JP, et al. Chronic pancreatitis and inflammatory bowel disease: true or coincidental association? Am J Gastroenterol 1999 94 : 2141 2148.
32. Ravi K, Chari ST, Vege SS, Sandborn WJ, Smyrk TC, Loftus EV Jr. Inflammatory bowel disease in the setting of autoimmune pancreatitis. Inflamm Bowel Dis 2009 15 : 1326 1330.
33. Ananthakrishnan AN, Beaulieu DB, Ulitsky A, et al. Does primary sclerosing cholangitis impact quality of life in patients with inflammatory bowel disease? Inflamm Bowel Dis 2009 16 : 494 500.
34. Imrie CW, Brombacher GD. Sclerosing cholangitis: a rare etiology for acute pancreatitis. Int J Pancreatol 1998 23 : 71 5.
35. Matsushita M, Nagasawa M, Sato Y, Souda K, Kobayashi Y. Primary sclerosing cholangitis associated with limy bile and acute pancreatitis. Pancreatology 2005 5 : 466 469.
36. Suresh E, Beadles W, Welsby P, Luqmani R. Acute pancreatitis with pseudocyst formation in a patient with polyarteritis nodosa. J Rheumatol 2005 32 : 386 388.