Induction of apoptotic lesions in liver and lymphoid tissues and modulation of cytokine mRNA expression by acute exposure to deoxynivalenol in piglets

Journal of Veterinary Science

Volumn 11, Issue 1, 2010, Pages 107-113

  Mikami, Osamu ^a   Yamaguchi, Hiroyuki ^a,b   Murata, Hideo ^a,c   Nakajima, Yasuyuki ^a   Miyazaki, Shigeru ^a  

^a NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

^b Chubu Livestock Hygiene Center   (Japan)

^c KYOTO SANGYO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cytokine; Deoxynivalenol; Hepatocytes; Pigs

Indexed keywords

SUIDAE;

CYTOKINE; MESSENGER RNA; TRICHOTHECENE DERIVATIVE; VOMITOXIN;

ANIMAL; ANIMAL DISEASE; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CYTOCHEMISTRY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; LIVER; LYMPHOID TISSUE; NICK END LABELING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE;

ANIMALS; APOPTOSIS; CYTOKINES; GENE EXPRESSION REGULATION; HISTOCYTOCHEMISTRY; IN SITU NICK-END LABELING; LIVER; LYMPHOID TISSUE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECIFIC PATHOGEN-FREE ORGANISMS; SWINE; TRICHOTHECENES;

EID: 77952704260     PISSN: 1229845X     EISSN: None     Source Type: Journal    
DOI: 10.4142/jvs.2010.11.2.107     Document Type: Article

References (39)

1. Accensi F, Pinton P, Callu P, Abella-Bourges N, Guelfi JF, Grosjean F, Oswald IP. Ingestion of low doses of deoxynivalenol does not affect hematological, biochemical, or immune responses of piglets. J Anim Sci 2006, 84, 1935-1942.
2. Gown AM, Willingham MC. Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. J Histochem Cytochem 2002, 50, 449-454.
3. Azcona-Olivera JI, Ouyang Y, Murtha J, Chu FS, Pestka JJ. Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition. Toxicol Appl Pharmacol 1995, 133, 109-120.
4. Bergsjø B, Langseth W, Nafstad I, Jansen JH, Larsen HJ. The effects of naturally deoxynivalenol-contaminated oats on the clinical condition, blood parameters, performance and carcass composition of growing pigs. Vet Res Commun 1993, 17, 283-294.
5. Bradlaw JA, Swentzel KC, Alterman E, Hauswirth JW. Evaluation of purified 4-deoxynivalenol (vomitoxin) for unscheduled DNA synthesis in the primary rat hepatocyte-DNA repair assay. Food Chem Toxicol 1985, 23, 1063-1067.
6. Chen F, Ma Y, Xue C, Ma J, Xie Q, Wang G, Bi Y, Cao Y. The combination of deoxynivalenol and zearalenone at permitted feed concentrations causes serious physiological effects in young pigs. J Vet Sci 2008, 9, 39-44.
7. Coppock RW, Swanson SP, Gelberg HB, Koritz GD, Hoffman WE, Buck WB, Vesonder RF. Preliminary study of the pharmacokinetics and toxicopathy of deoxynivalenol (vomitoxin) in swine. Am J Vet Res 1985, 46, 169-174.
8. Cote LM, Beasley VR, Bratich PM, Swanson SP, Shivaprasad HL, Buck WB. Sex-related reduced weight gains in growing swine fed diets containing deoxynivalenol. J Anim Sci 1985, 61, 942-950.
9. Dänicke S, Valenta H, Klobasa F, Döll S, Ganter M, Flachowsky G. Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Arch Anim Nutr 2004, 58, 1-17.
10. Dini L, Pagliara P, Carlà EC. Phagocytosis of apoptotic cells by liver: a morphological study. Microsc Res Tech 2002, 57, 530-540.
11. Drochner W, Schollenberger M, Götz S, Lauber U, Tafaj M, Piepho HP. Subacute effects of moderate feed loads of isolated Fusarium toxin deoxynivalenol on selected parameters of metabolism in weaned growing piglets. J Anim Physiol Anim Nutr (Berl) 2006, 90, 421-428.
12. Gelberg HB. Alimentary system. In: McGavin MD, Zachary JF (eds.). Pathologic Basis of Veterinary Disease. 4th ed. pp. 301-391, Elsevier, St. Louis, 2007.
13. Goyarts T, Grove N, Dänicke S. Effects of the Fusarium toxin deoxynivalenol from naturally contaminated wheat given subchronically or as one single dose on the in vivo protein synthesis of peripheral blood lymphocytes and plasma proteins in the pig. Food Chem Toxicol 2006, 44, 1953-1965.
14. Ihara T, Sugamata M, Sekijima M, Okumura H, Yoshino N, Ueno Y. Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis. Nat Toxins 1997, 5, 141-145.
15. Königs M, Schwerdt G, Gekle M, Humpf HU. Effects of the mycotoxin deoxynivalenol on human primary hepatocytes. Mol Nutr Food Res 2008, 52, 830-839.
16. Li M, Cuff CF, Pestka J. Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol. Toxicol Sci 2005, 87, 134-145.
17. Mikami O, Muneta Y, Mori Y, Yokomizo Y, Nakajima Y. Expression of proinflammatory cytokine mRNA in the lymphatic organs of adult and neonatal pigs. Vet Immunol Immunopathol 2002, 90, 203-207.
18. Mikami O, Yamamoto S, Yamanaka N, Nakajima Y. Porcine hepatocyte apoptosis and reduction of albumin secretion induced by deoxynivalenol. Toxicology 2004, 204, 241-249.
19. Nakajima Y, Momotani E, Takahashi H, Ishikawa Y, Ito T, Kanesaki M, Madarame H. Endogenous tumor necrosis factor (TNF) production and modification of pathological lesions in experimental Escherichia coli endotoxemia of piglets. Vet Immunol Immunopathol 1995, 45, 45-54.
20. Pestka JJ. Mechanisms of deoxynivalenol-induced gene expression and apoptosis. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2008, 25, 1128-1140.
21. Pestka JJ, Tai JH, Witt MF, Dixon DE, Forsell JH. Suppression of immune response in the B6C3F1 mouse after dietary exposure to the Fusarium mycotoxins deoxynivalenol (vomitoxin) and zearalenone. Food Chem Toxicol 1987, 25, 297-304.
22. Pestka JJ, Yan D, King LE. Flow cytometric analysis of the effects of in vitro exposure to vomitoxin (deoxynivalenol) on apoptosis in murine T, B and IgA+ cells. Food Chem Toxicol 1994, 32, 1125-1136.
23. Pestka JJ, Zhou HR, Moon Y, Chung YJ. Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox. Toxicol Lett 2004, 153, 61-73.
24. Pestka JJ, Smolinski AT. Deoxynivalenol: toxicology and potential effects on humans. J Toxicol Environ Health B Crit Rev 2005, 8, 39-69.
25. Pinton P, Accensi F, Beauchamp E, Cossalter AM, Callu P, Grosjean F, Oswald IP. Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses. Toxicol Lett 2008, 177, 215-222.
26. Prelusky DB, Trenholm HL. Tissue distribution of deoxynivalenol in swine dosed intravenously. J Agric Food Chem 1991, 39, 748-751.
27. Prelusky DB, Gerdes RG, Underhill KL, Rotter BA, Jui PY, Trenholm HL. Effects of low-level dietary deoxynivalenol on haematological and clinical parameters of the pig. Nat Toxins 1994, 2, 97-104.
28. Resendes AR, Majó N, Segalés J, Espadamala J, Mateu E, Chianini F, Nofrarías M, Domingo M. Apoptosis in normal lymphoid organs from healthy normal, conventional pigs at different ages detected by TUNEL and cleaved caspase-3 immunohistochemistry in paraffin-embedded tissues. Vet Immunol Immunopathol 2004, 99, 203-213.
29. Rothkötter HJ, Sowa E, Pabst R. The pig as a model of developmental immunology. Hum Exp Toxicol 2002, 21, 533-536.
30. Rotter BA, Prelusky DB, Pestka JJ. Toxicology of deoxynivalenol (vomitoxin). J Toxicol Environ Health 1996, 48, 1-34.
31. Sahu SC, Garthoff LH, Robl MG, Chirtel SJ, Ruggles DI, Flynn TJ, Sobotka TJ. Rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products: hepatotoxicity of deoxynivalenol. J Appl Toxicol 2008, 28, 765-772.
32. Sugita-Konishi Y, Hara-Kudo Y, Kasuga F, Kumagai S. Effect of trichothecenes on host defense against infectious diseases. Mycotoxins 1998, 47, 19-23.
33. Sun XM, Zhang XH, Wang HY, Cao WJ, Yan X, Zuo LF, Wang JL, Wang FR. Effects of sterigmatocystin, deoxynivalenol and aflatoxin G1 on apoptosis of human peripheral blood lymphocytes in vitro. Biomed Environ Sci 2002, 15, 145-152.
34. Tiemann U, Brüssow KP, Küchenmeister U, Jonas L, Kohlschein P, Pöhland R, Dänicke S. Influence of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected enzymatic and histological parameters of liver in gilts. Food Chem Toxicol 2006, 44, 1228-1235.
35. Trenholm HL, Hamilton RM, Friend DW, Thompson BK, Hartin KE. Feeding trials with vomitoxin (deoxynivalenol)-contaminated wheat: effects on swine, poultry, and dairy cattle. J Am Vet Med Assoc 1984, 185, 527-531.
36. Young LG, McGirr L, Valli VE, Lumsden JH, Lun A. Vomitoxin in corn fed to young pigs. J Anim Sci 1983, 57, 655-664.
37. Zhou HR, Harkema JR, Hotchkiss JA, Yan D, Roth RA, Pestka JJ. Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs. Toxicol Sci 2000, 53, 253-263.
38. Zhou HR, Islam Z, Pestka JJ. Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin. Toxicol Sci 2003, 72, 130-142.
39. Zhou HR, Yan D, Pestka JJ. Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): dose response and time course. Toxicol Appl Pharmacol 1997, 144, 294-305.