Eicosapentaenoic acid-induced endothelium-dependent and -independent relaxation of sheep pulmonary artery

European Journal of Pharmacology

Volumn 636, Issue 1-3, 2010, Pages 108-113

  Singh, Thakur Uttam ^a,b   Kathirvel, Kandasamy ^b   Choudhury, Soumen ^a,b   Garg, Satish Kumar ^a   Mishra, Santosh Kumar ^b  

^a Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan   (India)

^b INDIAN VETERINARY RESEARCH INSTITUTE   (India)

Author keywords

1400W; Eicosapentaenoic acid; Endothelium; Nitric oxide; Pulmonary artery

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; ICOSAPENTAENOIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; ISOLATED ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; SHEEP;

ACETYLCHOLINE; ANIMALS; CALCIUM; CALCIUM CHLORIDE; EICOSAPENTAENOIC ACID; ENDOTHELIUM, VASCULAR; EXTRACELLULAR SPACE; FATTY ACIDS; INTRACELLULAR SPACE; MALE; NIFEDIPINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; POTASSIUM; PULMONARY ARTERY; SEROTONIN; SEROTONIN ANTAGONISTS; SHEEP; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 77952670048     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.02.041     Document Type: Article

References (22)

1. Abeywardena M.Y., Head R.J. Long chain n-3 polyunsaturated fatty acids and blood vessels function. Cardiovasc. Res. 2001, 52:367-371.
2. Archer S.L., Johnson G.J., Gebhard R.L., Castleman W.L., Levine A.S., Westcott J.Y., Voelkel N.F., Nelson D.P., Weir E.K. Effect of dietary fish oil on lung lipid profile and hypoxic pulmonary hypertension. J. Appl. Physiol. 1989, 66:1662-1673.
3. Bawankule D.U., Sathishkumar K., Sardar K.K., Chanda D., Krishna A.V., Prakash V.R., Mishra S.K. BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)- 1H-pyrazolo [3,4-b]pyridine-3-yl]pyrimidin-4-ylamine]-induced dilation in ovine pulmonary artery: role of sodium pump. J. Pharmacol. Exp. Ther. 2005, 314:207-213.
4. +-ATPase in the regulation of basal tone and agonist-induced contractility in ovine pulmonary artery. J. Cardiovasc. Pharmacol. 2008, 52:167-175.
5. De Berrazueta J.R., Gómez de Berrazueta J.M., Amado Señarís J.A., Peña Sarabia N., Fernández Viadero C., García-Unzueta M.T., Sáez de Adana M., Sanchez Ovejero C.J., Llorca J. A diet enriched with mackerel (Scomber scombrus)-derived products improve the endothelial function in a senior population. Eur. J. Clin. Invest. 2009, 39:165-173.
6. Engler M.B., Engler M.M., Browne A., Sun Y.P., Sievers R. Mechanisms of vasorelaxation induced by eicosapentaenoic acid (20:5n-3) in WKY rat aorta. Br. J. Pharmacol. 2000, 131:1793-1799.
7. 2+ current in guinea-pig tracheal smooth muscle cells. Eur. J. Pharmacol. 1998, 355:257-266.
8. Horrocks L.A., Yeo Y.K. Health benefits of docosahexaenoic acid (DHA). Pharmacol. Res. 1999, 40:211-225.
9. Khan F., Elherik K., Bolton-Smith C., Barr R., Hill A., Murrie I., Belch J.J. The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. Cardiovasc. Res. 2003, 59:955-962.
10. Kris-Etherton P.M., Harris W.S., Appel L.J. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002, 106:2747-2757.
11. Leo M.D., Siddegowda Y.K., Kumar D., Tandan S.K., Sastry K.V., Prakash V.R., Mishra S.K. Role of nitric oxide and carbon monoxide in N (omega)-nitro-l-arginine methyl ester-resistant acetylcholine-induced relaxation in chicken carotid artery. Eur. J. Pharmacol. 2008, 596:111-117.
12. Lynn M.A., Rupnow H.L., Kleinhenz D.J., Kanner W.A., Dudley S.C., Hart C.M. Fatty acids differentially modulate insulin-stimulated endothelial nitric oxide production by an Akt-independent pathway. J. Investig. Med. 2004, 52:129-136.
13. Morin C., Sirois M., Echave V., Rizcallah E., Rousseau1 E. Relaxing effects of 17(18)-EpETE on arterial and airway smooth muscles in human lung. Am. J. Physiol. Lung Cell Mol. Physiol. 2009, 296:L130-L139.
14. (2+) influx, and response of vascular smooth muscle cells to 5-hydroxytryptamine. Stroke 2000, 31:2500-2507.
15. Nobukata H., Ishikawa T., Obata M., Shibutani Y. Long-term administration of highly purified eicosapentaenoic acid ethyl ester improves the dysfunction of vascular endothelial and smooth muscle cells in male WBN/Kob rats. Metabolism 2000, 49:1588-1591.
16. 2+ mobilization and PKC activity in vascular smooth muscle cells. Am. J. Hyperten. 2003, 16:708-714.
17. 2+-independent activation and translocation of endothelial nitric oxide synthase and endothelium- dependent vasorelaxation. FEBS Lett. 2001, 487:361-366.
18. Shimokawa H., Vanhoutte P.M. Dietary omega 3 fatty acids and endothelium-dependent relaxations in porcine coronary arteries. Am. J. Physiol. 1989, 256:H968-H973.
19. Uji Y., Noma A., Shiraki M., Maeda M., Tsuji A., Okabe H. Separation and quantitation of plasma free fatty acids as phenacyl esters by HPLC. Biomed. Chromatogr. 1987, 2:110-114.
20. 2+ sensitization: rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697. Biochem. J. 2005, 389:763-774.
21. 2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes. Proc. Natl. Acad. Sci. 1997, 94:4182-4187.
22. Yuan X.J., Bright R.T., Aldinger A.M., Rubin L.J. Nitric oxide inhibits serotonin-induced calcium release in pulmonary artery smooth muscle cells. Am. J. Physiol. 1997, 272:L44-L50.