Eicosapentaenoic acid inhibits Ca2+ mobilization and PKC activity in vascular smooth muscle cells

American Journal of Hypertension

Volumn 16, Issue 9 I, 2003, Pages 708-714

  Nyby, Michael D ^a,c   Hori, Mark T ^b   Ormsby, Bernard ^b   Gabrielian, Ara ^b   Tuck, Michael L ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

5, 8, 11, 14, 17 eicosapentaenoic acid; Angiotensin II; Calcium signaling; Protein kinase C

Indexed keywords

5,8,11,14,17 ICOSAPENTAENOIC ACID; ANGIOTENSIN; CALCIUM ION; FURA 2; ICOSAPENTAENOIC ACID; PHOSPHOLIPID; PROTEIN KINASE C; THAPSIGARGIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CATION TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GAS CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SARCOPLASMIC RETICULUM; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

EID: 0141506110     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(03)00980-4     Document Type: Article

References (29)

1. Dyerberg J, Bang HO, Stoffersen E, Moncada S, Vane JR: Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 1978;2:117-119.
2. Hui R, St Louis J, Falardeau P: Antihypertensive properties of linoleic acid and fish oil omega-3 fatty acids independent of the prostaglandin system. Am J Hypertens 1989;2:610-617.
3. Knapp HR, FitzGerald GA: The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. N Engl J Med 1989;320:1037-1043.
4. Miyajima T, Tsujino T, Saito K, Yokoyama M: Effects of eicosapentaenoic acid on blood pressure, cell membrane fatty acids, and intracellular sodium concentration in essential hypertension. Hypertens Res 2001;24:537-542.
5. Juan H, Sutter D, Sametz W: Influence of eicosapentaenoic acid on noradrenaline and angiotensin- induced contractions of the rabbit aorta: mode of action. Prog Clin Biol Res 1987;242:57-62.
6. Engler MB: Vascular relaxation to omega-3 fatty acids: comparison to sodium nitroprusside, nitroglycerin, papaverine, and D600. Cardiovasc Drugs Ther 1992;6:605-610.
7. Engler MB, Ma YH, Engler MM: Calcium-mediated mechanisms of eicosapentaenoic acid-induced relaxation in hypertensive rat aorta. Am J Hypertension 1999;12:1225-1235.
8. 2+ influx and cell proliferation in rat aortic smooth muscle cell lines. Eur J Pharmacol 1999;379:199-209.
9. Saito F, Hori MT, Ideguchi Y, Berger M, Golub M, Stern N, Tuck ML: 12-Lipoxygenase products modulate calcium signals in vascular smooth muscle cells. Hypertension 1992;20:138-143.
10. Hara A, Radin NS: Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem 1978;90:420-426.
11. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260:3440-3450.
12. 2+-ATPase. Proc Natl Acad Sci 1990;87:2466-2470.
13. Kanda H, Hori MT, Golub MS, Tuck ML: Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways. Am J Hypertens 2001;14:248-253.
14. Merritt JE, Jacob R, Hallam TJ: Use of manganese to discriminate between calcium influx and mobilization from internal stores in stimulated human neutrophils. J Biol Chem 1989;264:1522-1527.
15. Hui R, Robillard M, Falardeau P: Inhibition of vasopressin-induced formation of diradrylglycerols in vascular smooth muscle cells by incorporation of eicosapentaenoic acid in membrane phospholipids. J Hypertens 1992;10:1145-1153.
16. Ullian ME: Fatty acid inhibition of angiotensin II-stimulated inositol phosphates in smooth muscle cells. Am J Physiol 1993;264:H595-H603.
17. 2+ pool in T cells through a mechanism independent of phosphoinositide turnover. J Biol Chem 1990;265:902-907.
18. Negretti N, Perez MR, Walker D, O'Neill SC: Inhibition of sarcoplasmic reticulum function by polyunsaturated fatty acids in intact, isolated myocytes from rat ventricular muscle. J Physiol 2000;523:367-375.
19. O'Neill SC, Perez MR, Hammond KE, Sheader EA, Negretti N: Direct and indirect modulation of rat cardiac sarcoplasmic reticulum function by N-3 polyunsaturated fatty acids. J Physiol 2002;538:179-184.
20. Touyz RH, Schiffrin EL: Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 2000;52:639-672.
21. Kuroki T, Inoguchi T, Umeda F, Nawata H: Effect of eicosapentaenoic acid on glucose-induced diacylglycerol synthesis in cultured bovine aortic endothelial cells. Biochem Biophys Res Commun 1998;247:473-477.
22. Kohno M, Ohmori K, Wada Y, Kondo I, Noma T, Fujita N, Mizushige K, Mandal AK: Inhibition by eicosapentaenoic acid of oxidized-LDL- and lysophosphatidylcholine-induced human coronary artery smooth muscle cell production of endothelin. J Vasc Res 2001;38:379-388.
23. Nair SS, Leitch J, Garg ML: N-3 polyunsaturated fatty acid supplementation alters inositol phosphate metabolism and protein kinase C activity in adult porcine cardiac myocytes. J Nutr Biochem 2001;12:7-13.
24. Pakala R, Pakala R, Sheng WL, Benedict CR: Eicosapentaenoic acid and docosahexaneoic acid block serotonin-induced smooth muscle cell proliferation. Arterioscler Thromb Vas Biol 1999;19:2316-2322.
25. Pakala R, Pakala R, Benedict CR: Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. Prostaglandins, Leukotrienes and Essential Fatty Acids 1999;60:275-281.
26. Nakayama M, Fukuda N, Watanabe Y, Soma M, Hu W-Y, Kishioka H, Satoh C, Kubo A, Kanmatsuse K: Low dose of eicosapentaenoic acid inhibits the exaggerated growth of vascular smooth muscle cells from spontaneously hypertensive rats through suppression of transforming growth factor-β. J Hypertens 1999;17:1421-1430.
27. Okazaki J, Mawatari K, Kent KC: The effect of protein kinase C and its alpha subtype on human vascular smooth muscle cell proliferation, migration and fibronectin production. Surgery 2000;128:192-197.
28. Liao DF, Monia B, Dean N, Berk BC: Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells. J Biol Chem 1997;272:6146-6150.
29. Denys A, Hichami A, Khan A: Eicosapentaenoic acid and docosahexaneoic acid modulate MAP kinase (ERK1/ERK2) signaling in human T cells. J Lipid Res 2001;42:2015-2020.