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Organic and Biomolecular Chemistry
Volumn 8, Issue 11, 2010, Pages 2543-2552
Photosensitized cleavage of plasmidic DNA by norharmane, a naturally occurring β-carboline
Author keywords

[No Author keywords available]
Indexed keywords

AQUEOUS SOLUTIONS; BIOLOGICAL PROCESS; CARBOLINES; DNA MOLECULES; DNA STRAND BREAK; EFFECT OF PH; ELECTRON TRANSFER; ELECTRONIC EXCITED STATE; HETEROCYCLIC COMPOUND; HYDROXYL RADICALS; KINETIC STUDY; METHYL DERIVATIVES; NATURALLY OCCURRING; PHOTOCLEAVAGE REACTION; PHYSIOLOGICAL PH; PROTONATED; REACTIVE OXYGEN SPECIES; SINGLET OXYGEN; SUPEROXIDE ANIONS; UVA RADIATION;
EID: 77952631234     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/c002235g     Document Type: Article
Times cited : (27)
References (73)
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    • F = 0.68 and 0.75 for the neutral and protonated form of N-Me-nHo, respectively), ∼ 90% of the neutral form of N-Me-nHo follows a quick protonation during the lifetime of its singlet excited states
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    • 2 production. This suggests that the photosensitized damage to cells caused by this β-carboline derivative could involve other routes from the singlet oxygen attack on DNA
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    • a value of βCMAM is 3.877. In the pH range 6-9, the neutral form of βCMAM is the predominant specie in the solution. Thus, the absence of the positive charge would decrease the interaction with the DNA molecule. On the other hand, at pH 4 ∼ 50% of each acid-base form of βCMAM are present. Although in the protonated βCMAM form, the norharmane skeleton plane is twisted by 19.58° with respect to the plane carbon 3 substituent,77 the availability of the protonated pyridinic nitrogen is not the same as in the case of norharmane
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.