3-Amino-1, 4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) Sensitizes Mammalian Cells to UV Radiation by Causing the S-Phase Arrest, Not by Inhibiting the Repair of DNA Damage as Observed in Escherichia coli

Journal of Radiation Research

Volumn 39, Issue 1, 1998, Pages 21-33

  Mori, Toshio ^a   Nakagawa, Akemi ^a   Kobayashi, Nobuhiko ^a   Hashimoto, Mitsumasa W ^b   Wakabayashi, Keiji ^c   Shimoi, Kayoko ^d   Kinae, Naohide ^d  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

(6 4)Photoproducts; Cyclobutane pyrimidine dimers; Flow cytometry; S phase arrest; Trp P 1

Indexed keywords

CELLS; CYTOLOGY; DNA; ESCHERICHIA COLI; IRRADIATION; MAMMALS; MONOCLONAL ANTIBODIES; POLYCYCLIC AROMATIC HYDROCARBONS;

(6-4)PHOTOPRODUCT; CYCLOBUTANE PYRIMIDINE DIMERS; MAMMALIAN CELLS; PHASE ARREST; PHOTOPRODUCTS; S-PHASE; S-PHASE ARREST; TRP-P-1; UV INDUCED; UV-INDUCED DNA DAMAGE;

REPAIR;

CRICETINAE; CRICETULUS GRISEUS; ESCHERICHIA COLI; MAMMALIA;

3 AMINO 1,4 DIMETHYL 5H PYRIDO[4,3 B]INDOLE; CARBOLINE DERIVATIVE; DNA; RADIOSENSITIZING AGENT; TRP-P-1;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CYCLE S PHASE; CELL DIVISION; CHO CELL; DNA DAMAGE; DNA REPAIR; DRUG EFFECT; ESCHERICHIA COLI; HAMSTER; HELA CELL; HUMAN; METABOLISM; RADIATION EXPOSURE; ULTRAVIOLET RADIATION;

ANIMALS; CARBOLINES; CELL DIVISION; CHO CELLS; CRICETINAE; DNA; DNA DAMAGE; DNA REPAIR; ESCHERICHIA COLI; HELA CELLS; HUMANS; RADIATION-SENSITIZING AGENTS; S PHASE; ULTRAVIOLET RAYS;

EID: 0032015152     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.39.21     Document Type: Article

References (36)

1. Sugimura, T. (1982) Mutagens, carcinogens and tumor promoters in our daily food. Cancer 49: 1970-1984.
2. Felton, J. S., Knize, M. G., Shen, N. H., Andersen, B. D., Bjeldanes, L. F. and Hatch, F. T. (1986) Identification of the mutagens in cooked beef. Environ. Health Perspect. 67: 17-24.
3. Sasaki, M., Sugimura, K., Yoshida, M. A. and Kawachi, T. (1980) Chromosome aberrations and sister chromatid exchanges induced by tryptophan pyrolysates. Trp-P-1 and Trp-P-2. in cultured human and Chinese hamster cells. Proc. Jpn. Acad. 56: 332-337.
4. Nakayasu, M., Nakasato, F., Sakamoto, H., Terada, M. and Sugimura, T. (1983) Mutagenic activity of heterocyclic amines in Chinese hamster lung cells with diphtheria toxin resistance as a marker. Mutat. Res. 118: 91-102.
5. Matsukura, N., Kawachi, T., Morino, K., Ohgaki, H., Sugimura, T. and Takayama, S. (1981) Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolysate. Science 213: 346-347.
6. Sugimura, T. (1986) Studies on environmental chemical carcinogenesis in Japan. Science 233: 312-318.
7. Aeschbacher, H.-U. and Turesky, R. J. (1991) Mammalian cell mutagenicity and metabolism of heterocyclic aromatic amines. Mutat. Res. 259: 235-230.
8. Nagao, M., Yahagi, T., Kawachi, T., Sugimura, T., Kosuge, T., Tsuji, K., Wakabayashi, K., Shigenohu, M. and Matsumoto, T. (1977) Comutagenic action of norharman and harman. Proc. Jpn. Acad. 53: 95-98.
9. Okui, T. and Fujiwara, Y. (1986) Inhibition of human excision DNA repair by inorganic arsenic and the co-mutagenic effect in V79 Chinese hamster cells. Mutat. Res. 172: 69-76.
10. Shimoi, K., Nakamura, Y., Tomita, I. and Kada, T. (1985) Bio-antimutagenic effects of tannic acid on UV and chemically induced mutagenesis in Escherichia coli B/r. Mutat. Res. 14: 17-23.
11. 6 in E. coli and mouse peripheral blood cells. Mutat. Res. 266: 205-213.
12. Shimoi, K., Kawabata, H. and Tomita, I. (1992) Enhancing effect of heterocyclic amines and K-carbolines on UV or chemically induced mutagenesis in E. coli. Mutat. Res. 268: 287-295.
13. Mori, T., Shimoi, K., Sasaki, Y. F., Wakabayashi, K., Nagao, M. and Kinae, N. (1993) 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) inhibits the removal of both cyclobutane dimers and (6-4) photoproducts from the DNA of ultraviolet-irradiated E. coli. Carcinogenesis 14: 1475-1478.
14. Shimoi, K., Miyamura, R., Mori, T., Todo, T., Ohtsuka, E., Wakabayashi, K. and Kinae, N. (1996) 3-Amino-1,4-dimethyl-5H-pyhdo[4,3-b]indole (Trp-P-1) inhibits the binding activity of T4 endonuclease V to UV-damaged DNA. Carcinogenesis 17: 1279-1283.
15. Sasaki, Y. F., Yamada, H., Shimoi, K., Kinae, N., Tomita, I., Matsumura, H., Ohta, T. and Shirasu, Y. (1992) Enhancing effects of heterocyclic amines and B-carbolines on the induction of chromosome aberrations in cultured mammalian cells. Mutat. Res. 269: 79-95.
16. Mori, T., Nakane, M., Hattori, T., Matsunaga, T., Ihara, M. and Nikaido, O. (1991) Simultaneous establishment of monoclonal antibodies specific for either cyclobutane pyrimidine dimer or (6-4)photoproduct from the same mouse immunized with ultraviolet-irradiated DNA. Photochem. Photobiol. 54: 225-232.
17. Kobayashi, N., Muramatsu, T., Yamashina, Y., Shirai, T., Ohnishi, T. and Mori, T. (1993) Melanin reduces ultraviolet-induced DNA damage formation and killing rate in cultured human melanoma cells. J. Invest. Dermatol. 101: 685-689.
18. Matsunaga, T., Mori, T. and Nikaido, O. (1990) Base sequence specificity of a monoclonal antibody binding to (6-4)photoproducts. Mutat. Res. 235: 187-194.
19. Bohr, V. A., Smith, C. A., Okumoto, D. S. and Hanawall, P. C. (1985) DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell 40: 359-369.
20. Mizuno, T., Matsunaga, T., Ihara, M. and Nikaido, O. (1991) Establishment of a monoclonal antibody recognizing cyclobutane-type thymidine dimers in DNA: a comparative study with 64M-1 antibody specific for (6-4)photoproducts. Mutat. Res. 254: 175-184.
21. Mitchell, D. L., Haipek, C. A. and Clarkson, J. M. (1985) (6-4)Photoproducts are removed from the DNA of UV-irradiated mammalian cells more efficiently than cyclobutane pyrimidine dimers. Mutat. Res. 143: 109-112.
22. Hayashi, K., Nagao, M. and Sugimura, T. (1977) Interactions of norharman and harman with DNA. Nucleic Acids Res. 4: 3679-3685.
23. Castellani, A. and Setlow, R. B. (1981) Harman inhibits the removal of pyrimidine dimers from the DNA of human cells. Biochem. Biophys. Res. Commun. 98: 823-828.
24. Chang, C.-C., Castellazzi, M., Glover, T. W. and Trosko, J. E. (1978) Effects of harman and norharman on spontaneous and ultraviolet light-induced mutagenesis in cultured Chinese hamster cells. Cancer Res. 38: 4527-4533.
25. Sancar, A. (1994) Mechanisms of DNA excision repair. Science 266: 1954-1956.
26. Doniger, J. (1978) DNA replication in ultraviolet light irradiated Chinese hamster cells: The nature of replicon inhibition and post-replication repair. J. Mol. Biol. 120: 433-446.
27. Kaufmann, W. K. and Cleaver, J. E. (1981) Mechanism of inhibition of DNA replication by ultraviolet light in normal human and xeroderma pigmentosum fibroblasts. J. Mol. Biol. 149: 171-187.
28. Mayne, L. V. and Lehmann, A. R. (1982) Failure of RNA synthesis to recover after UV irradiation: An early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum. Cancer Res. 42: 1473-1478.
29. Ayak, H., Hara, R. and Ikenaga, M. (1996) Recovery from ultraviolet light-induced depression of ribosomal RNA synthesis in normal human, xeroderma pigmentosum and Cockayne syndrome cells. J. Radiat. Res. 37: 107-116.
30. Kung, A. L., Zetterberg, A., Sherwood, S. W. and Schimke, R. T. (1990) Cytotoxic effects of cell cycle phase specific agents: Result of cell cycle perturbation. Cancer Res. 50: 7307-7317.
31. Kung, A. L., Sherwood, S. W. and Schimke, R. T. (1993) Differences in the regulation of protein synthesis, cyclin B accumulation, and cellular growth in response to the inhibition of DNA synthesis in Chinese hamster ovary and HeLa S3 cells. J. Biol. Chem. 268: 23072-23080.
32. Waldman, T., Lengauer, C., Kinzler, K. W. and Vogelstein, B. (1996) Uncoupling of S phase and mitosis mduced by anticancer agents in cells lacking p21. Nature 381:713-716.
33. 2. J. Radiat. Res. 38: 95-102.
34. Inohara, T., Tarui, M., Doi, M. Inoue, M. and Ishida, T. (1993) Interaction of mutagenic tryptophan pyrolysate with DNA CD spectral study on the binding specificity. FEBS Lett. 324: 301-304.
35. Mattern, M. R. and Painter, R. B. (1979) Dependence of mammalian DNA replication on DNA supercoiling I. Effects of ethidium bromide on DNA synthesis in permeable Chinese hamster ovary cells. Biochim. Biophys. Acta 563: 293-305.
36. Painter, R. B. (1978) Inhibition of DNA replication initiation by 4-nitroqumoline 1-oxide, adriamycin, and ethyleneimine. Cancer Res. 38: 4445-1449.