Malaria: Looking for selection signatures in the human PKLR gene region

British Journal of Haematology

Volumn 149, Issue 5, 2010, Pages 775-784

  MacHado, Patrícia ^a   Pereira, Rui ^b,c   Rocha, Ana Mafalda ^b   Manco, Licínio ^d,e   Fernandes, Natércia ^f   Miranda, Juliana ^g   Ribeiro, Letícia ^e   Do Rosário, Virgílio E ^a   Amorim, António ^b   Gusmão, Leonor ^b   Arez, Ana Paula ^a  

^a INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^f Universidade Eduardo Mondlane   (Portugal)

^g Hospital Pediatrico David Bernardino   (Angola)

Author keywords

Human malaria; Molecular markers; PKLR; Pyruvate kinase deficiency; Selection signatures

Indexed keywords

PYRUVATE KINASE;

ANGOLA; ARTICLE; CHROMOSOME 1Q; CONTROLLED STUDY; ENZYME DEFICIENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; HAPLOTYPE; HUMAN; HUMAN GENOME; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MOZAMBIQUE; NUCLEOTIDE SEQUENCE; POPULATION GENETICS; PORTUGAL; PRIORITY JOURNAL; RACE DIFFERENCE; SHORT TANDEM REPEAT; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN CONTINENTAL ANCESTRY GROUP; CHILD; CHROMOSOMES, HUMAN, PAIR 1; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE DISEQUILIBRIUM; MALARIA, FALCIPARUM; MICROSATELLITE REPEATS; POLYMORPHISM, SINGLE NUCLEOTIDE; PYRUVATE KINASE; SELECTION, GENETIC;

EID: 77952609107     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08165.x     Document Type: Article

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