Commensal pathogens, with a focus on Streptococcus pneumoniae, and interactions with the human host

Experimental Cell Research

Volumn 316, Issue 8, 2010, Pages 1408-1414

  Henriques Normark, Birgitta ^a   Normark, Staffan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Commensal pathogens; Host pathogen interactions; Innate immunity; Streptococcus pneumoniae

Indexed keywords

ADAPTIVE IMMUNITY; BACTERIAL COLONIZATION; BACTERIAL VIRULENCE; DISEASE CARRIER; DISEASE SEVERITY; ECOLOGICAL NICHE; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HOST PATHOGEN INTERACTION; HUMAN; INNATE IMMUNITY; MOLECULAR EPIDEMIOLOGY; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; REVIEW; STREPTOCOCCUS PNEUMONIAE; MICROBIOLOGY; PHYSIOLOGY;

STREPTOCOCCUS PNEUMONIAE;

HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; PNEUMOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE;

EID: 77952558570     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2010.03.003     Document Type: Review

References (52)

1. Persson O.P., Pinhassi J., Riemann L., Marklund B.I., Rhen M., Normark S., González J.M., Hagström A. High abundance of virulence gene homologues in marine bacteria. Environ. Microbiol. 2009, 11(6):1348-1357.
2. Hornef M.W., Wick M.J., Rhen M., Normark S. Bacterial strategies for overcoming host innate and adaptive immune responses. Nat. Immunol. 2002, 3:1033-1040.
3. Cossart P., Sansonetti P.J. Bacterial invasion: the paradigms of enteroinvasive pathogens. Science 2004, 304:242-2488.
4. Klugman K.P., Madhi S.A. Pneumococcal vaccines and flu preparedness. Science 2007, 316:49-50.
5. Daniels R., Mellroth P., Bernsel A., Neiers F., Normark S., von Heijne G., Henriques-Normark B. Disulfide bond formation and cysteine exclusion in gram-positive bacteria. J. Biol. Chem. 2010, 285:3300-3309.
6. Davis K.M., Akinbi H.T., Standish A.J., Weiser J.N. Resistance to mucosal lysozyme compensates for the fitness deficit of peptidoglycan modifications by Streptococcus pneumoniae. PLoS Pathog. 2008, 4:e1000241.
7. Regev-Yochay G., Trzcinski K., Thompson C.M., Malley R., Lipsitch M. Interference between Streptococcus pneumoniae and Staphylococcus aureus: in vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae. J. Bacteriol. 2006, 188:4996-5001.
8. Kadioglu A., Weiser J.N., Paton J.C., Andrew P.W. The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nat. Rev. Microbiol. 2008, 6:288-301.
9. Barocchi M., Ries J., Zogaj X., Albiger B., Kanth A., Dahlberg S., Moschioni M., Masignani V., Hultenby K., von Euler A., Holden D.W., Covacci A., Normark S., Rappuoli R., Henriques-Normark B. A pneumococcal pilus influences virulence and host inflammatory responses. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:2857-2862.
10. Nelson A.L., Ries J., Bagnoli F., Dahlberg S., Rounioja S., Tschöp J., Morfeldt E., Ferlenghi I., Hilleringmann M., Holden D., Rappuoli R., Normark S., Barocchi M.A., Henriques-Normark B. RrgA is a pilus-associated adhesin and virulence factor in S. pneumoniae. Mol. Microbiol. 2007, 66:329-340.
11. Borén T., Falk P., Roth K.A., Larson G., Normark S. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 1993, 262:1892-1895.
12. Ilver D., Arnqvist A., Ogren J., Frick I.M., Kersulyte D., Incecik E.T., Berg D.E., Covacci A., Engstrand L., Borén T. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science 1998, 279:373-377.
13. Aspholm-Hurtig M., Dailide G., Lahmann M., Kalia A., Ilver D., Roche N., Vikstrom S., Sjostrom R., Linden S., Backstrom A., Lundberg C., Arnqvist A., Mahdavi J., Nilsson U.J., Velapatino B., Gilman R.H., Gerhard M., Alarcon T., Lopez-Brea M., Nakazawa T., Fox J.G., Correa P., Dominguez-Bello M.G., Perez-Perez G.I., Blaser M.J., Normark S., Carlstedt I., Oscarson S., Teneberg S., Berg D.E., Boren T. Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science 2004, 305:519-522.
14. Mahdavi J., Sondén B., Hurtig M., Olfat F.O., Forsberg L., Roche N., Angstrom J., Larsson T., Teneberg S., Karlsson K.A., Altraja S., Wadström T., Kersulyte D., Berg D.E., Dubois A., Petersson C., Magnusson K.E., Norberg T., Lindh F., Lundskog B.B., Arnqvist A., Hammarström L., Borén T. Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science 2002, 297:573-578.
15. Schauer R. Sialic acids: fascinating sugars in higher animals and man. Zoology (Jena) 2004, 107:49-64.
16. Kawano T., Koyama S., Takematsu H., Kozutsumi Y., Kawasaki H., Kawashima S., Kawasaki T., Suzuki A. Molecular cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase. Regulation of species- and tissue-specific expression of N-glycolylneuraminic acid. J. Biol. Chem. 1995, 270:16458-16463.
17. Chou H.H., Takematsu H., Diaz S., Iber J., Nickerson E., Wright K.L., Muchmore E.A., Nelson D.L., Warren S.T., Varki A. A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:11751-11756.
18. Byres E., Paton A.W., Paton J.C., Löfling J.C., Smith D.F., Wilce M.C., Talbot U.M., Chong D.C., Yu H., Huang S., Chen X., Varki N.M., Varki A., Rossjohn J., Beddoe T. Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature 2008, 456:648-652.
19. Uchiyama S., Carlin A.F., Khosravi A., Weiman S., Banerjee A., Quach D., Hightower G., Mitchell T.J., Doran K.S., Nizet V. The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. J. Exp. Med. 2009, 206(9):1845-1852.
20. Trappetti C., Kadioglu A., Carter M., Hayre J., Iannelli F., Pozzi G., Andrew P.W., Oggioni M.R. Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host. J. Infect. Dis. 2009, 199:1497-1505.
21. Schneider M.C., Prosser B.E., Caesar J.J., Kugelberg E., Li S., Zhang Q., Quoraishi S., Lovett J.E., Deane J.E., Sim R.B., Roversi P., Johnson S., Tang C.M., Lea S.M. Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates. Nature 2009, 458:890-893.
22. Yuste J., Khandavilli S., Ansari N., Muttardi K., Ismail L., Hyams C., Weiser J., Mitchell T., Brown J.S. The effects of PspC on complement-mediated immunity to Streptococcus pneumoniae vary with strain background and capsular serotype. Infect Immun. 2010, 78:283-292.
23. Dieudonné-Vatran A., Krentz S., Blom A.M., Meri S., Henriques-Normark B., Riesbeck K., Albiger B. Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion. J. Immunol. 2009, 182:7865-7877.
24. Hiller N.L., Janto B., Hogg J.S., Boissy R., Yu S., Powell E., Keefe R., Ehrlich N.E., Shen K., Hayes J., Barbadora K., Klimke W., Dernovoy D., Tatusova T., Parkhill J., Bentley S.D., Post J.C., Ehrlich G.D., Hu F.Z. Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome. J. Bacteriol. 2007, 189:8186-8195.
25. Blomberg J., Dagerhamn J., Morfeldt E., Sjöström K., Normark S., Henriques-Normark B. Pattern of accessory regions and invasive disease potential in Streptococcus pneumoniae. J. Infect. Dis. 2009, 199:1032-1042.
26. Hava D.L., Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Mol. Microbiol. 2002, 45:1389-1406.
27. Sjöström K., Blomberg C., Fernebro J., Dagerhamn J., Morfeldt E., Barocchi M., Andersson M., Browall S., Henriques F., Rappuoli R., Normark S., Henriques-Normark B. Clonal success of piliated penicillin non-susceptible pneumococci. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:12907-12912.
28. Brueggemann A.B., Peto T.E., Crook D.W., Butler J.C., Kristinsson K.G., Spratt B.G. Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children. J. Infect. Dis. 2004, 190:1203-1211.
29. Sandgren A., Albiger B., Orihuela C.J., Tuomanen E., Normark S., Henriques-Normark B. Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans. J. Infect. Dis. 2005, 192:791-800.
30. Sjöström K., Spindler C., Ortqvist A., Kalin M., Sandgren A., Kühlmann-Berenzon S., Henriques-Normark B. Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen. Clin. Infect. Dis. 2006, 42:451-459.
31. Wang R., Braughton K.R., Kretschmer D., Bach T.H., Queck S.Y., Li M., Kennedy A.D., Dorward D.W., Klebanoff S.J., Peschel A., DeLeo F.R., Otto M. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat. Med. 2007, 13:1510-1514.
32. Ku C.L., von Bernuth H., Picard C., Zhang S.Y., Chang H.H., Yang K., Chrabieh M., Issekutz A.C., Cunningham C.K., Gallin J., Holland S.M., Roifman C., Ehl S., Smart J., Tang M., Barrat F.J., Levy O., McDonald D., Day-Good N.K., Miller R., Takada H., Hara T., Al-Hajjar S., Al-Ghonaium A., Speert D., Sanlaville D., Li X., Geissmann F., Vivier E., Maródi L., Garty B.Z., Chapel H., Rodriguez-Gallego C., Bossuyt X., Abel L., Puel A., Casanova J.L. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J. Exp. Med. 2007, 204:2407-2422.
33. Khor C.C., Chapman S.J., Vannberg F.O., Dunne A., Murphy C., Ling E.Y., Frodsham A.J., Walley A.J., Kyrieleis O., Khan A., Aucan C., Segal S., Moore C.E., Knox K., Campbell S.J., Lienhardt C., Scott A., Aaby P., Sow O.Y., Grignani R.T., Sillah J., Sirugo G., Peshu N., Williams T.N., Maitland K., Davies R.J., Kwiatkowski D.P., Day N.P., Yala D., Crook D.W., Marsh K., Berkley J.A., O'Neill L.A., Hill A.V. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat. Genet. 2007, 39:523-528.
34. Albiger B., Sandgren A., Katsuragi H., Meyer-Hoffert U., Beiter K., Wartha F., Hornef M., Normark S., Normark B.H. Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice. Cell Microbiol. 2005, 7:1603-1615.
35. Albiger B., Dahlberg S., Sandgren A., Wartha F., Beiter K., Katsuragi H., Akira S., Normark S., Henriques-Normark B. Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol. 2007, 9:633-644.
36. Wang J., Barke R.A., Charboneau R., Schwendener R., Roy S. Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-kappa B signalling. J. Immunol. 2008, 180:3594-3600.
37. Sun K., Metzger D.W. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat. Med. 2008, 14:558-564.
38. Didierlaurent A., Goulding J., Patel S., Snelgrove R., Low L., Bebien M., Lawrence T., van Rijt L.S., Lambrecht B.N., Sirard J.C., Hussell T. Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. J. Exp. Med. 2008, 205:323-329.
39. Kirby A.C., Coles M.C., Kaye P.M. Alveolar macrophages transport pathogens to lung draining lymph nodes. J. Immunol. 2009, 183:1983-1989.
40. Cundell D.R., Gerard N.P., Gerard C., Idanpaan-Heikkila I., Tuomanen E.I. Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature 1995, 377:435-438.
41. Brinkmann V., Reichard U., Goosmann C., Fauler B., Uhlemann Y., Weiss D.S., Weinrauch Y., Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science 2004, 303:1532-1535.
42. Beiter K., Wartha F., Albiger B., Normark S., Zychlinsky A., Henriques-Normark B. An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps. Curr. Biol. 2006, 16:401-417.
43. Wartha F., Beiter K., Albiger B., Fernebro J., Zychlinsky A., Normark S., Henriques-Normark B. Capsule and d-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps. Cell Microbiol. 2007, 9:1162-1171.
44. Buchanan J.T., Simpson A.J., Aziz R.K., Liu G.Y., Kristian S.A., Kotb M., Feramisco J., Nizet V. DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. Curr. Biol. 2006, 16:396-400.
45. de Haas C.J., Veldkamp K.E., Peschel A., Weerkamp F., Van Wamel W.J., Heezius E.C., Poppelier M.J., van Kessel K.P., van Strijp J.A. Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent. J. Exp. Med. 2004, 199:687-695.
46. Prat C., Bestebroer J., de Haas C.J., van Strijp J.A., van Kessel K.P. A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1. J. Immunol. 2006, 177:8017-8026.
47. Hidalgo-Grass C., Mishalian I., Dan-Goor M., Belotserkovsky I., Eran Y., Nizet V., Peled A., Hanski E. Streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues. EMBO J. 2006, 25:4628-4637.
48. Thulin P., Johansson L., Low D.E., Gan B.S., Kotb M., McGeer A., Norrby-Teglund A. Viable group A streptococci in macrophages during acute soft tissue infection. PLoS Med. 2006, 3:e53.
49. Clarke T.B., Davis K.M., Lysenko E.S., Zhou A.Y., Yu Y., Weiser J.N. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat. Med. 2010, 16:228-231.
50. Malley R., Trzcinski K., Srivastava A., Thompson C.M., Anderson P.W., Lipsitch M. CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:4848-4853.
51. Zhang Z., Clarke T.B., Weiser J.N. Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice. J. Clin. Invest. 2009, 119:1899-1909.
52. Littmann M., Albiger B., Frentzen A., Normark S., Henriques-Normark B., Plant L. Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression. EMBO Mol. Med. 2009, 1:211-222.