Functional properties of the human ventral mesencephalic neural stem cell line hVM1

Experimental Neurology

Volumn 223, Issue 2, 2010, Pages 653-656

  Tønnesen, Jan ^a   Seiz, Emma Gonzalez ^b   Ramos, Milagros ^b   Lindvall, Olle ^a   Martinez Serrano, Alberto ^b   Kokaia, Merab ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

Differentiation; Dopaminergic neuron; Electrophysiology; Functional properties; Human neural stem cell; In vitro; Parkinson's disease

Indexed keywords

ARTICLE; CELL FUNCTION; CELL LINE; CELL MATURATION; CONTROLLED STUDY; FETAL STEM CELL; FETUS; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCEPHALON; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; PRIORITY JOURNAL;

ACTION POTENTIALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL SURVIVAL; CULTURE MEDIA; DOPAMINE; EMBRYONIC STEM CELLS; FETUS; HUMANS; MESENCEPHALON; NEURONS; PATCH-CLAMP TECHNIQUES; STEM CELL TRANSPLANTATION; TYROSINE 3-MONOOXYGENASE;

EID: 77952554364     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2010.01.013     Document Type: Article

References (22)

1. Cherubini E., Gaiarsa J.L., et al. GABA: an excitatory transmitter in early postnatal life. Trends Neurosci. 1991, 14(12):515-519.
2. Cho T., Bae J.H., et al. Human neural stem cells: electrophysiological properties of voltage-gated ion channels. Neuroreport 2002, 13(11):1447-1452.
3. De Filippis L., Lamorte G., et al. A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes. Stem Cells 2007, 25(9):2312-2321.
4. Donato R., Miljan E.A., et al. Differential development of neuronal physiological responsiveness in two human neural stem cell lines. BMC Neurosci. 2007, 8:36.
5. Jung M., Kramer E.M., et al. Novel pluripotential neural progenitor lines exhibiting rapid controlled differentiation to neurotransmitter receptor-expressing neurons and glia. Eur. J. Neurosci. 1998, 10(10):3246-3256.
6. Kim S.U. Genetically engineered human neural stem cells for brain repair in neurological diseases. Brain Dev. 2007, 29(4):193-201.
7. Lacey M.G., Mercuri N.B., et al. Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids. J. Neurosci. 1989, 9(4):1233-1241.
8. Lee H.J., Kim K.S., et al. Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model. Stem Cells 2007, 25(5):1204-1212.
9. Lindvall O., Bjorklund A. Cell therapy in Parkinson's disease. NeuroRx 2004, 1(4):382-393.
10. Lotharius J., Barg S., et al. Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J. Biol. Chem. 2002, 277(41):38884-38894.
11. Malmersjö S., Liste I., Dyachok O., Tengholm A., Arenas E., Uhlen P. Ca2+ and cAMP signaling in human embryonic stem cell-derived dopamine neurons. Stem Cells and Development 2009, (Electronic publication ahead of print). doi:10.1089/scd.2009.0436.
12. Martinez-Serrano A., Rubio F.J., et al. Human neural stem and progenitor cells: in vitro and in vivo properties, and potential for gene therapy and cell replacement in the CNS. Curr. Gene Ther. 2001, 1(3):279-299.
13. Nilsson J.A., Cleveland J.L. Myc pathways provoking cell suicide and cancer. Oncogene 2003, 22(56):9007-9021.
14. Parish C.L., Castelo-Branco G., et al. Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. J. Clin. Invest. 2008, 118(1):149-160.
15. Rabow L.E., Russek S.J., et al. From ion currents to genomic analysis: recent advances in GABAA receptor research. Synapse 1995, 21(3):189-274.
16. Riaz S.S., Jauniaux E., et al. The controlled conversion of human neural progenitor cells derived from foetal ventral mesencephalon into dopaminergic neurons in vitro. Brain Res. Dev. Brain Res. 2002, 136(1):27-34.
17. Rivera C., Voipio J., et al. The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 1999, 397(6716):251-255.
18. Ruiz F., Alvarez G., et al. Protection by pyruvate and malate against glutamate-mediated neurotoxicity. Neuroreport 1998, 9(7):1277-1282.
19. Villa A., Liste I., et al. Generation and properties of a new human ventral mesencephalic neural stem cell line. Exp. Cell Res. 2009, 315(11):1860-1874.
20. Villa A., Navarro B., et al. Genetic perpetuation of in vitro expanded human neural stem cells: cellular properties and therapeutic potential. Brain Res. Bull. 2002, 57(6):789-794.
21. Villa A., Navarro-Galve B., et al. Long-term molecular and cellular stability of human neural stem cell lines. Exp. Cell. Res. 2004, 294(2):559-570.
22. Villa A., Snyder E.Y., et al. Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS. Exp. Neurol. 2000, 161(1):67-84.