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Volumn 14, Issue 3, 2010, Pages 383-389

Diversity-oriented fluorescence library approaches for probe discovery and development

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; CELL MEMBRANE PERMEABILITY; CHELATION; DIVERSITY ORIENTED FLUORESCENCE LIBRARY; DNA PROBE; ENDOTHELIUM CELL; FLUORESCENCE; HIGH THROUGHPUT SCREENING; IMAGE ANALYSIS; IN VITRO STUDY; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PHENOTYPE; REVIEW; SENSOR; SOLUBILITY; SYNTHESIS;

EID: 77952543710     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2010.02.020     Document Type: Review
Times cited : (47)

References (49)
  • 1
    • 51249117322 scopus 로고    scopus 로고
    • High-throughput screens for fluorescent dye discovery
    • Ljosa V., and Carpenter A.E. High-throughput screens for fluorescent dye discovery. Trends Biotechnol 26 (2008) 527-530
    • (2008) Trends Biotechnol , vol.26 , pp. 527-530
    • Ljosa, V.1    Carpenter, A.E.2
  • 2
    • 39449137547 scopus 로고    scopus 로고
    • Synthetic fluorescent sensors for studying the cell biology of metals
    • Domaille D.W., Que E.L., and Chang C.J. Synthetic fluorescent sensors for studying the cell biology of metals. Nat Chem Biol 4 (2008) 168-175
    • (2008) Nat Chem Biol , vol.4 , pp. 168-175
    • Domaille, D.W.1    Que, E.L.2    Chang, C.J.3
  • 3
    • 59649112891 scopus 로고    scopus 로고
    • Fluorescent labeling of biomolecules with organic probes
    • Goncalves M.S. Fluorescent labeling of biomolecules with organic probes. Chem Rev 109 (2009) 190-212
    • (2009) Chem Rev , vol.109 , pp. 190-212
    • Goncalves, M.S.1
  • 4
    • 0347719288 scopus 로고    scopus 로고
    • Modular solid-phase synthetic approach to optimize structural and electronic properties of oligoboronic acid receptors and sensors for the aqueous recognition of oligosaccharides
    • Stones D., Manku S., Lu X., and Hall D.G. Modular solid-phase synthetic approach to optimize structural and electronic properties of oligoboronic acid receptors and sensors for the aqueous recognition of oligosaccharides. Chem Eur J 10 (2004) 92-100
    • (2004) Chem Eur J , vol.10 , pp. 92-100
    • Stones, D.1    Manku, S.2    Lu, X.3    Hall, D.G.4
  • 5
    • 0034716346 scopus 로고    scopus 로고
    • Coupling rational design with libraries leads to the production of an ATP selective chemosensor
    • Schneider S.E., O'Neil S.N., and Anslyn E.V. Coupling rational design with libraries leads to the production of an ATP selective chemosensor. J Am Chem Soc 122 (2000) 542-543
    • (2000) J Am Chem Soc , vol.122 , pp. 542-543
    • Schneider, S.E.1    O'Neil, S.N.2    Anslyn, E.V.3
  • 6
    • 0034597991 scopus 로고    scopus 로고
    • Combinatorial approach to the development of fluorescent sensors for nanomolar aqueous copper
    • Singh A., Yao Q.W., Tong L., Still W.C., and Sames D. Combinatorial approach to the development of fluorescent sensors for nanomolar aqueous copper. Tetrahedron Lett 41 (2000) 9601-9605
    • (2000) Tetrahedron Lett , vol.41 , pp. 9601-9605
    • Singh, A.1    Yao, Q.W.2    Tong, L.3    Still, W.C.4    Sames, D.5
  • 7
    • 17544398524 scopus 로고    scopus 로고
    • Fluorogenic and chromogenic chemosensors and reagents for anions
    • Martinez-Manez R., and Sancenon F. Fluorogenic and chromogenic chemosensors and reagents for anions. Chem Rev 103 (2003) 4419-4476
    • (2003) Chem Rev , vol.103 , pp. 4419-4476
    • Martinez-Manez, R.1    Sancenon, F.2
  • 8
    • 0034807678 scopus 로고    scopus 로고
    • Derivatives of 8-hydroxy-2-methylquinoline are powerful prototypes for zinc sensors in biological systems
    • Pearce D.A., Jotterand N., Carrico I.S., and Imperiali B. Derivatives of 8-hydroxy-2-methylquinoline are powerful prototypes for zinc sensors in biological systems. J Am Chem Soc 123 (2001) 5160-5161
    • (2001) J Am Chem Soc , vol.123 , pp. 5160-5161
    • Pearce, D.A.1    Jotterand, N.2    Carrico, I.S.3    Imperiali, B.4
  • 9
    • 0035905349 scopus 로고    scopus 로고
    • Single-compound libraries of organic materials: parallel synthesis and screening of fluorescent dyes
    • Schiedel M.S., Briehn C.A., and Bauerle P. Single-compound libraries of organic materials: parallel synthesis and screening of fluorescent dyes. Angew Chem Int Ed Engl 40 (2001) 4677-4678
    • (2001) Angew Chem Int Ed Engl , vol.40 , pp. 4677-4678
    • Schiedel, M.S.1    Briehn, C.A.2    Bauerle, P.3
  • 10
    • 10044258626 scopus 로고    scopus 로고
    • A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes
    • Sivakumar K., Xie F., Cash B.M., Long S., Barnhill H.N., and Wang Q. A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes. Org Lett 6 (2004) 4603-4606
    • (2004) Org Lett , vol.6 , pp. 4603-4606
    • Sivakumar, K.1    Xie, F.2    Cash, B.M.3    Long, S.4    Barnhill, H.N.5    Wang, Q.6
  • 11
    • 34147158804 scopus 로고    scopus 로고
    • Development of a library of 6-arylcoumarins as candidate fluorescent sensors
    • Hirano T., Hiromoto K., and Kagechika H. Development of a library of 6-arylcoumarins as candidate fluorescent sensors. Org Lett 9 (2007) 1315-1318
    • (2007) Org Lett , vol.9 , pp. 1315-1318
    • Hirano, T.1    Hiromoto, K.2    Kagechika, H.3
  • 12
    • 22944437475 scopus 로고    scopus 로고
    • Reversing the discovery paradigm: a new approach to the combinatorial discovery of fluorescent chemosensors
    • Mello J.V., and Finney N.S. Reversing the discovery paradigm: a new approach to the combinatorial discovery of fluorescent chemosensors. J Am Chem Soc 127 (2005) 10124-10125
    • (2005) J Am Chem Soc , vol.127 , pp. 10124-10125
    • Mello, J.V.1    Finney, N.S.2
  • 13
    • 33744514579 scopus 로고    scopus 로고
    • Combinatorial discovery of fluorophores and fluorescent probes
    • Finney N.S. Combinatorial discovery of fluorophores and fluorescent probes. Curr Opin Chem Biol 10 (2006) 238-245
    • (2006) Curr Opin Chem Biol , vol.10 , pp. 238-245
    • Finney, N.S.1
  • 14
    • 73649135748 scopus 로고    scopus 로고
    • Chemistry as a prism: a review of light-emitting materials having tunable emission wavelengths
    • Kim E., and Park S.B. Chemistry as a prism: a review of light-emitting materials having tunable emission wavelengths. Chem Asian J 4 (2009) 1646-1658
    • (2009) Chem Asian J , vol.4 , pp. 1646-1658
    • Kim, E.1    Park, S.B.2
  • 15
    • 67650314388 scopus 로고    scopus 로고
    • Rapid synthesis, screening, and identification of xanthone- and xanthene-based fluorophores using click chemistry
    • Li J.Q., Hu M.Y., and Yao S.Q. Rapid synthesis, screening, and identification of xanthone- and xanthene-based fluorophores using click chemistry. Org Lett 11 (2009) 3008-3011
    • (2009) Org Lett , vol.11 , pp. 3008-3011
    • Li, J.Q.1    Hu, M.Y.2    Yao, S.Q.3
  • 16
    • 36649020449 scopus 로고    scopus 로고
    • Combinatorial dapoxyl dye library and its application to site selective probe for human serum albumin
    • Min J., Lee J.W., Ahn Y.H., and Chang Y.T. Combinatorial dapoxyl dye library and its application to site selective probe for human serum albumin. J Comb Chem 9 (2007) 1079-1083
    • (2007) J Comb Chem , vol.9 , pp. 1079-1083
    • Min, J.1    Lee, J.W.2    Ahn, Y.H.3    Chang, Y.T.4
  • 17
    • 70449427458 scopus 로고    scopus 로고
    • Solution-phase synthesis of a diverse isocoumarin library
    • Roy S., Neuenswander B., Hill D., and Larock R.C. Solution-phase synthesis of a diverse isocoumarin library. J Comb Chem 11 (2009) 1128-1135
    • (2009) J Comb Chem , vol.11 , pp. 1128-1135
    • Roy, S.1    Neuenswander, B.2    Hill, D.3    Larock, R.C.4
  • 18
    • 36649014050 scopus 로고    scopus 로고
    • Solid-phase synthesis and modification of thiazole orange and its derivatives and their spectral properties
    • Fei X.N., Yang S.B., Zhang B.L., Liu Z.J., and Gu Y.C. Solid-phase synthesis and modification of thiazole orange and its derivatives and their spectral properties. J Comb Chem 9 (2007) 943-950
    • (2007) J Comb Chem , vol.9 , pp. 943-950
    • Fei, X.N.1    Yang, S.B.2    Zhang, B.L.3    Liu, Z.J.4    Gu, Y.C.5
  • 19
    • 45149125024 scopus 로고    scopus 로고
    • Diversity-oriented fluorescence library approach (DOFLA) to the discovery of chymotrypsin sensor
    • Wang S.L., Kim Y.K., and Chang Y.T. Diversity-oriented fluorescence library approach (DOFLA) to the discovery of chymotrypsin sensor. J Comb Chem 10 (2008) 460-465
    • (2008) J Comb Chem , vol.10 , pp. 460-465
    • Wang, S.L.1    Kim, Y.K.2    Chang, Y.T.3
  • 20
    • 60749109182 scopus 로고    scopus 로고
    • Catch and release microwave mediated synthesis of cyanine dyes
    • Lopalco M., Koini E.N., Cho J.K., and Bradley M. Catch and release microwave mediated synthesis of cyanine dyes. Org Biomol Chem 7 (2009) 856-859
    • (2009) Org Biomol Chem , vol.7 , pp. 856-859
    • Lopalco, M.1    Koini, E.N.2    Cho, J.K.3    Bradley, M.4
  • 22
    • 60849135124 scopus 로고    scopus 로고
    • Solid phase synthesis of N-alkyl-bis-o-aminobenzamides for metal ion sensing based on a fluorescent dansyl platform
    • Pina-Luis G., Ochoa-Teran A., and Rivero I.A. Solid phase synthesis of N-alkyl-bis-o-aminobenzamides for metal ion sensing based on a fluorescent dansyl platform. J Comb Chem 11 (2009) 83-90
    • (2009) J Comb Chem , vol.11 , pp. 83-90
    • Pina-Luis, G.1    Ochoa-Teran, A.2    Rivero, I.A.3
  • 23
    • 17044427161 scopus 로고    scopus 로고
    • Parallel synthesis of strongly fluorescent polysubstituted 2,6-dicyanoanilines via microwave-promoted multicomponent reaction
    • Cui S.L., Lin X.F., and Wang Y.G. Parallel synthesis of strongly fluorescent polysubstituted 2,6-dicyanoanilines via microwave-promoted multicomponent reaction. J Org Chem 70 (2005) 2866-2869
    • (2005) J Org Chem , vol.70 , pp. 2866-2869
    • Cui, S.L.1    Lin, X.F.2    Wang, Y.G.3
  • 24
    • 51949094773 scopus 로고    scopus 로고
    • Combinatorial discovery of full-color-tunable emissive fluorescent probes using a single core skeleton, 1,2-dihydropyrrolo[3,4-beta]indolizin-3-one
    • An interesting example of the power of combinatorial chemistry to implement structural and spectral diversity in a full-color tunable novel fluorescent skeleton.
    • Kim E., Koh M., Ryu J., and Park S.B. Combinatorial discovery of full-color-tunable emissive fluorescent probes using a single core skeleton, 1,2-dihydropyrrolo[3,4-beta]indolizin-3-one. J Am Chem Soc 130 (2008) 12206-12207. An interesting example of the power of combinatorial chemistry to implement structural and spectral diversity in a full-color tunable novel fluorescent skeleton.
    • (2008) J Am Chem Soc , vol.130 , pp. 12206-12207
    • Kim, E.1    Koh, M.2    Ryu, J.3    Park, S.B.4
  • 25
    • 65349182363 scopus 로고    scopus 로고
    • Diversity-oriented fluorescence library approach for the discovery of sensors and probes
    • Lee J.S., Kim Y.K., Vendrell M., and Chang Y.T. Diversity-oriented fluorescence library approach for the discovery of sensors and probes. Mol BioSyst 5 (2009) 411-421
    • (2009) Mol BioSyst , vol.5 , pp. 411-421
    • Lee, J.S.1    Kim, Y.K.2    Vendrell, M.3    Chang, Y.T.4
  • 26
    • 0037419787 scopus 로고    scopus 로고
    • Combinatorial approach to organelle-targeted fluorescent library based on the styryl scaffold
    • Rosania G.R., Lee J.W., Ding L., Yoon H.S., and Chang Y.T. Combinatorial approach to organelle-targeted fluorescent library based on the styryl scaffold. J Am Chem Soc 125 (2003) 1130-1131
    • (2003) J Am Chem Soc , vol.125 , pp. 1130-1131
    • Rosania, G.R.1    Lee, J.W.2    Ding, L.3    Yoon, H.S.4    Chang, Y.T.5
  • 27
    • 0041667772 scopus 로고    scopus 로고
    • Development of novel cell-permeable DNA sensitive dyes using combinatorial synthesis and cell-based screening
    • Lee J.W., Jung M., Rosania G.R., and Chang Y.T. Development of novel cell-permeable DNA sensitive dyes using combinatorial synthesis and cell-based screening. Chem Commun (2003) 1852-1853
    • (2003) Chem Commun , pp. 1852-1853
    • Lee, J.W.1    Jung, M.2    Rosania, G.R.3    Chang, Y.T.4
  • 28
    • 45149090641 scopus 로고    scopus 로고
    • Selective human serum albumin sensor from the screening of a fluorescent rosamine library
    • Ahn Y.H., Lee J.S., and Chang Y.T. Selective human serum albumin sensor from the screening of a fluorescent rosamine library. J Comb Chem 10 (2008) 376-380
    • (2008) J Comb Chem , vol.10 , pp. 376-380
    • Ahn, Y.H.1    Lee, J.S.2    Chang, Y.T.3
  • 29
    • 34247538391 scopus 로고    scopus 로고
    • Combinatorial rosamine library and application to in vivo glutathione probe
    • Ahn Y.H., Lee J.S., and Chang Y.T. Combinatorial rosamine library and application to in vivo glutathione probe. J Am Chem Soc 129 (2007) 4510-4511
    • (2007) J Am Chem Soc , vol.129 , pp. 4510-4511
    • Ahn, Y.H.1    Lee, J.S.2    Chang, Y.T.3
  • 30
    • 41549155107 scopus 로고    scopus 로고
    • Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening
    • The first reference of an unbiased high-throughput screening of a diversity-oriented fluorescent library to successfully discover a probe able to discriminate myotubes and myoblasts in muscle cells.
    • Wagner B.K., Carrinski H.A., Ahn Y.H., Kim Y.K., Gilbert T.J., Fomina D.A., Schreiber S.L., Chang Y.T., and Clemons P.A. Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening. J Am Chem Soc 130 (2008) 4208-4209. The first reference of an unbiased high-throughput screening of a diversity-oriented fluorescent library to successfully discover a probe able to discriminate myotubes and myoblasts in muscle cells.
    • (2008) J Am Chem Soc , vol.130 , pp. 4208-4209
    • Wagner, B.K.1    Carrinski, H.A.2    Ahn, Y.H.3    Kim, Y.K.4    Gilbert, T.J.5    Fomina, D.A.6    Schreiber, S.L.7    Chang, Y.T.8    Clemons, P.A.9
  • 31
    • 36849053388 scopus 로고    scopus 로고
    • BODIPY dyes and their derivatives: syntheses and spectroscopic properties
    • Loudet A., and Burgess K. BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Chem Rev 107 (2007) 4891-4932
    • (2007) Chem Rev , vol.107 , pp. 4891-4932
    • Loudet, A.1    Burgess, K.2
  • 32
    • 67651207209 scopus 로고    scopus 로고
    • Synthesis of a BODIPY library and its application to the development of live cell glucagon imaging probe
    • A very recent example of the combinatorial derivatization of highly fluorescent structures to develop novel turn-on sensors, and the discovery of a glucagon probe by means of a cell-based imaging HTS.
    • Lee J.S., Kang N.Y., Kim Y.K., Samanta A., Feng S.H., Kim H.K., Vendrell M., Park J.H., and Chang Y.T. Synthesis of a BODIPY library and its application to the development of live cell glucagon imaging probe. J Am Chem Soc 131 (2009) 10077-10082. A very recent example of the combinatorial derivatization of highly fluorescent structures to develop novel turn-on sensors, and the discovery of a glucagon probe by means of a cell-based imaging HTS.
    • (2009) J Am Chem Soc , vol.131 , pp. 10077-10082
    • Lee, J.S.1    Kang, N.Y.2    Kim, Y.K.3    Samanta, A.4    Feng, S.H.5    Kim, H.K.6    Vendrell, M.7    Park, J.H.8    Chang, Y.T.9
  • 33
    • 40149087996 scopus 로고    scopus 로고
    • Discovery of heparin chemosensors through diversity oriented fluorescence library approach
    • Wang S.L., and Chang Y.T. Discovery of heparin chemosensors through diversity oriented fluorescence library approach. Chem Commun (2008) 1173-1175
    • (2008) Chem Commun , pp. 1173-1175
    • Wang, S.L.1    Chang, Y.T.2
  • 34
    • 11144310569 scopus 로고    scopus 로고
    • Solid-phase synthesis of styryl dyes and their application as amyloid sensors
    • Together with [35], this work is an example of the overall fluorescent probe development, from library synthesis and in vitro primary screening to an eventual application for in vivo imaging.
    • Li Q.A., Lee J.S., Ha C., Park C.B., Yang G., Gan W.B., and Chang Y.T. Solid-phase synthesis of styryl dyes and their application as amyloid sensors. Angew Chem Int Ed Engl 43 (2004) 6331-6335. Together with [35], this work is an example of the overall fluorescent probe development, from library synthesis and in vitro primary screening to an eventual application for in vivo imaging.
    • (2004) Angew Chem Int Ed Engl , vol.43 , pp. 6331-6335
    • Li, Q.A.1    Lee, J.S.2    Ha, C.3    Park, C.B.4    Yang, G.5    Gan, W.B.6    Chang, Y.T.7
  • 36
    • 33745202571 scopus 로고    scopus 로고
    • RNA-selective, live cell imaging probes for studying nuclear structure and function
    • Li Q., Kim Y., Namm J., Kulkarni A., Rosania G.R., Ahn Y.H., and Chang Y.T. RNA-selective, live cell imaging probes for studying nuclear structure and function. Chem Biol 13 (2006) 615-623
    • (2006) Chem Biol , vol.13 , pp. 615-623
    • Li, Q.1    Kim, Y.2    Namm, J.3    Kulkarni, A.4    Rosania, G.R.5    Ahn, Y.H.6    Chang, Y.T.7
  • 37
    • 33747590798 scopus 로고    scopus 로고
    • Combinatorial synthesis of benzimidazolium dyes and its diversity directed application toward GTP-selective fluorescent chemosensors
    • Wang S.L., and Chang Y.T. Combinatorial synthesis of benzimidazolium dyes and its diversity directed application toward GTP-selective fluorescent chemosensors. J Am Chem Soc 128 (2006) 10380-10381
    • (2006) J Am Chem Soc , vol.128 , pp. 10380-10381
    • Wang, S.L.1    Chang, Y.T.2
  • 38
    • 74049103498 scopus 로고    scopus 로고
    • Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries
    • The first example of a fluorescent nanoparticle library as in vivo imaging agents to stain specific cell types.
    • Kelly K.A., Shaw S.Y., Nahrendorf M., Kristoff K., Aikawa E., Schreiber S.L., Clemons P.A., and Weissleder R. Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries. Integr Biol 1 (2009) 311-317. The first example of a fluorescent nanoparticle library as in vivo imaging agents to stain specific cell types.
    • (2009) Integr Biol , vol.1 , pp. 311-317
    • Kelly, K.A.1    Shaw, S.Y.2    Nahrendorf, M.3    Kristoff, K.4    Aikawa, E.5    Schreiber, S.L.6    Clemons, P.A.7    Weissleder, R.8
  • 40
    • 66349113402 scopus 로고    scopus 로고
    • New fluorescence microscopy methods for microbiology: sharper, faster, and quantitative
    • Gitai Z. New fluorescence microscopy methods for microbiology: sharper, faster, and quantitative. Curr Opin Microbiol 12 (2009) 341-346
    • (2009) Curr Opin Microbiol , vol.12 , pp. 341-346
    • Gitai, Z.1
  • 41
    • 33947355325 scopus 로고    scopus 로고
    • Single-cell quantification of molecules and rates using open-source microscope-based cytometry
    • Gordon A., Colman-Lerner A., Chin T.E., Benjamin K.R., Yu R.C., and Brent R. Single-cell quantification of molecules and rates using open-source microscope-based cytometry. Nat Methods 4 (2007) 175-181
    • (2007) Nat Methods , vol.4 , pp. 175-181
    • Gordon, A.1    Colman-Lerner, A.2    Chin, T.E.3    Benjamin, K.R.4    Yu, R.C.5    Brent, R.6
  • 43
    • 52449130309 scopus 로고    scopus 로고
    • High-content analysis in neuroscience
    • Dragunow M. High-content analysis in neuroscience. Nat Rev Neurosci 9 (2008) 779-788
    • (2008) Nat Rev Neurosci , vol.9 , pp. 779-788
    • Dragunow, M.1
  • 44
    • 34447502161 scopus 로고    scopus 로고
    • Image-based chemical screening
    • A concise perspective review highlighting the general needs, limitations and key steps in the development of image-based high-content screenings.
    • Carpenter A.E. Image-based chemical screening. Nat Chem Biol 3 (2007) 461-465. A concise perspective review highlighting the general needs, limitations and key steps in the development of image-based high-content screenings.
    • (2007) Nat Chem Biol , vol.3 , pp. 461-465
    • Carpenter, A.E.1
  • 45
    • 67649111551 scopus 로고    scopus 로고
    • An overview of cell phenotypes in HCS: limitations and advantages
    • Gasparri F. An overview of cell phenotypes in HCS: limitations and advantages. Expert Opin Drug Discov 4 (2009) 643-657
    • (2009) Expert Opin Drug Discov , vol.4 , pp. 643-657
    • Gasparri, F.1
  • 46
    • 55649105063 scopus 로고    scopus 로고
    • Analysis of signaling events by combining high-throughput screening technology with computer-based image analysis
    • Kodiha M., Brown C.M., and Stochaj U. Analysis of signaling events by combining high-throughput screening technology with computer-based image analysis. Sci Signal 1 pl2 (2008) 1-18
    • (2008) Sci Signal , vol.1 , Issue.pl2 , pp. 1-18
    • Kodiha, M.1    Brown, C.M.2    Stochaj, U.3
  • 47
    • 35348858911 scopus 로고    scopus 로고
    • Cell-based high-content screening of small-molecule libraries
    • Korn K., and Krausz E. Cell-based high-content screening of small-molecule libraries. Curr Opin Chem Biol 11 (2007) 503-510
    • (2007) Curr Opin Chem Biol , vol.11 , pp. 503-510
    • Korn, K.1    Krausz, E.2
  • 48
    • 0029329537 scopus 로고
    • Desperately seeking sensors
    • Czarnik A.W. Desperately seeking sensors. Chem Biol 2 (1995) 423-428
    • (1995) Chem Biol , vol.2 , pp. 423-428
    • Czarnik, A.W.1


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