Glutathione synthesis inhibitor butathione sulfoximine regulates ceruloplasmin by dual but opposite mechanism: Implication in hepatic iron overload

Free Radical Biology and Medicine

Volumn 48, Issue 11, 2010, Pages 1492-1500

  Tapryal, Nisha ^a   Mukhopadhyay, Chaitali ^a   Mishra, Manoj Kumar ^a   Das, Dola ^a   Biswas, Sudipta ^a   Mukhopadhyay, Chinmay K ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

AP 1; Ceruloplasmin; Gene regulation; Glutathione depletion; Hepatic iron overload; MRNA decay

Indexed keywords

ACETYLCYSTEINE; BINDING PROTEIN; BUTATHIONE SULFOXIMINE; CERULOPLASMIN; CHLORAMPHENICOL ACETYLTRANSFERASE; ENZYME INHIBITOR; GLUTAMATE CYSTEINE LIGASE INHIBITOR; GLUTATHIONE; MESSENGER RNA; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG MECHANISM; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IRON BALANCE; IRON OVERLOAD; IRON STORAGE; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING;

3' UNTRANSLATED REGIONS; ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; CERULOPLASMIN; GLUTATHIONE; HEP G2 CELLS; HUMANS; IRON; IRON OVERLOAD; LIVER; RNA, MESSENGER;

HEPATITIS C VIRUS;

EID: 77952541323     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.02.029     Document Type: Article

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