Use of the near-infrared reflectance method for measurement of moisture content during granulation

Pharmaceutical Development and Technology

Volumn 5, Issue 2, 2000, Pages 209-217

  Rantanen, Jukka ^a   Antikainen, Osmo ^a   Mannermaa, Jukka Pekka ^a   Yliruusi, Jouko ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Fluidized bed granulation; Moisture measurement; Near infrared (NIR); Tablet; Water

Indexed keywords

MANNITOL; PLACEBO; POVIDONE; STARCH; WATER;

AEROSOL; ARTICLE; DESICCATION; DRUG FORMULATION; DRUG GRANULATION; FLUIDIZED BED; INFRARED SPECTROMETRY; MOISTURE; PARTICLE SIZE; PRIORITY JOURNAL; REFLECTOMETRY;

DRUG COMPOUNDING; HARDNESS; HUMIDITY; MANNITOL; PARTICLE SIZE; POWDERS; SPECTROSCOPY, NEAR-INFRARED; STARCH; TABLETS;

EID: 0034057750     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100100536     Document Type: Article

References (29)

1. D. M. Newitt and J. M. Conway-Jones, A contribution to the theory and practice of granulation, Trans. Inst. Chem. Eng., 36, 422-440 (1958).
2. H. Rumpf, Grundlagen und Methoden des Granulierens, Chemie Ing. Technol., 30(3), 144-158 (1958).
3. P. G. Smith and A. W. Nienow, Particle growth mechanisms in fluidized bed granulation - I. The effect of process variables, Chem. Eng. Sci., 38(8), 1223-1231 (1982).
4. E. Shotton and J. E. Rees, The compaction properties of sodium chloride in the presence of moisture, J. Pharm. Pharmacol. Suppl., 18, 160S-167S (1966).
5. Z.T. Chowhan and L. Palagyi, Hardness increase induced by partial moisture loss in compressed tablets and its effect on in vitro dissolution, J. Pharm. Sci., 67(10), 1385-1389 (1978).
6. J. A. H. de Jong, Tablet properties as a function of the properties of granules made in a fluidized bed granulator, Powder Technol., 65, 293-303 (1991).
7. M. Hyland and D. Naunapper, Continuous control of product moisture content in drying processes, Drugs Made Ger., 31(1), 29-36 (1988).
8. K. M. Morisseau and C. T. Rhodes, Pharmaceutical uses of near-infrared spectroscopy, Drug Dev. Ind. Pharm., 21(9), 1071-1090 (1995).
9. M. Blanco, J. Coello, H. Iturriaga, S. Maspoch, and C. de la Pezuela, Near-infrared spectroscopy in pharmaceutical industry, Analyst, 123, 135R-150R (1998).
10. K. M. Morriseau and C. T. Rhodes, Proven and potential uses of near-infrared spectroscopy for the evaluation of tablets, Pharm. Technol. Yearbook 1997, 6-12 (1997).
11. J. E. Sinsheimer and N. M. Poswalk, Pharmaceutical applications of the near infrared determination of water, J. Pharm. Sci., 57(11), 2007-2010 (1968).
12. M. S. Kamat, R. A. Lodder, and P. P. DeLuca, Near-infrared spectroscopic determination of residual moisture in lyophilized sucrose through intact glass vials, Pharm. Res., 6(11), 961-965 (1989).
13. I. R. Last and K. A. Prebble, Suitability of near-infrared methods for the determination of moisture in a freeze-dried injection product containing different amounts of the active ingredient, J. Pharm. Biomed. Anal., 11(11/ 12), 1071-1076 (1993).
14. J. A. Jones, I. R. Last, B. F. Macdonald, and K. A. Prebble, Development and transferability of near-infrared methods for determination of moisture in a freeze-dried injection product, J. Pharm. Biomed. Anal., 11(11/12), 1227-1231 (1993).
15. M. W. J. Derksen, P. J. M. van de Oetelaar, and F. A. Maris, The use of near-infrared spectroscopy in the efficient prediction of the residual moisture of a freeze-dried product, J. Pharm. Biomed. Anal., 17, 473-480 (1998).
16. W. Plugge and C. van der Vlies, Near-infrared spectroscopy as an alternative to assess compliance of ampicillin trihydrate with compendial specifications, J. Pharm. Biomed. Anal., 11(6), 435-442 (1993).
17. E. Dreassi, G. Ceramelli, P. Corti, P. L. Perruccio, and S. Lonardi, Application of near-infrared reflectance spectrometry to the analytical control of pharmaceuticals: ranitidine hydrochloride tablet production, Analyst, 121, 219-222 (1996).
18. M. Blanco, J. Coello, H. Iturriaga, S. Maspoch, and E. Rovira, Determination of water in ferrous lactate by near infrared reflectance spectroscopy with a fibre-optic probe, J. Pharm. Biomed. Anal., 16, 255-262 (1997).
19. S. Watano, K. Terashita, and K. Miyanami, Development and application of infrared moisture sensor to complex granulation, Bull. Univ. Osaka. Pref., Series A, 39(2), 187-197 (1990).
20. J. G. White, On-line moisture detection for a microwave vacuum dryer, Pharm. Res., 11(5), 728-732 (1994).
21. P. Frake, D. Greenhalgh, S. M. Grierson, J. M. Hempenstall, and D. R. Rudd, Process control and end-point determination of a fluid bed granulation by application of near infra-red spectroscopy, Int. J. Pharm., 151, 75-80 (1997).
22. S. G. Goebel and K.-J. Steffens, Online-messung der Produktfeuchte und Korngröβe in der Wirbelschnicht mit der Nah-Infrarot-Spektroskopie, Pharm. Ind., 60(10), 889-895 (1998).
23. J. Rantanen, S. Lehtola, P. Rämet, J.-P. Mannermaa, and J. Yliruusi, On-line monitoring of moisture content in an instrumented fluidized bed granulator with a multichannel NIR moisture sensor, Powder Technol., 99(2), 163-170 (1998).
24. T. Niskanen, J. Yliruusi, M. Niskanen, and O. Kontro, Granulation of potassium chloride in fluidized bed granulator - Part I: Effect of flow rate, Acta Pharm. Fenn., 99, 13-22 (1990).
25. P. Merkku, J. Yliruusi, and L. Hellén, Testing of an automated laboratory scale fluidized bed granulator using different bed loads, Acta Pharm. Fenn., 101, 173-180 (1992).
26. T. Schæfer and O. Wørts, Control of fluidized bed granulation III. Effect of inlet air temperature and liquid flow rate on granule size and size distribution. Control of moisture content of granules in the drying phase, Arch. Pharm. Chem. Sci., 6, 1-13 (1978).
27. J. Vertommen, P. Rombaut, A. Michoel, and R. Kinget, Estimation of amount of water removed by gap and atomization air streams during palletization in a rotary processor, Pharm. Dev. Technol., 3(1), 63-72 (1998).
28. T. Schæfer and O. Wørts, Control of fluidized bed granulation II. Estimation of droplet size of atomized binder solutions, Arch. Pharm. Chem. Sci., 5, 178-193 (1977).
29. D. Desai, M. Schrad, H. Joshi, R. Tejwani, and N. Jain, Role of residual moisture in enhancement of hardness of tablets made with poorly compressible materials, Pharm. Sci., 1(1), S-321 (1998).